Skin science article
Isntree Ultra-Low Molecular Hyaluronic Acid Serum Versus SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule
Isntree Ultra-Low Molecular Hyaluronic Acid Serum Versus SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule This hydrating serum is formulated around Panthenol and Hydrolyzed Hyaluronic Acid to hydrate skin and strengthen the skin barrier. This brig
Isntree Ultra-Low Molecular Hyaluronic Acid Serum Versus SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule
This hydrating serum is formulated around Panthenol and Hydrolyzed Hyaluronic Acid to hydrate skin and strengthen the skin barrier.
This brightening ampoule is formulated around Niacinamide and Tranexamic Acid to brighten dull-looking skin and fade the look of dark spots.
What's inside
Key Ingredients
Benefits
Ingredients Side-by-side
Sea Water
Water
Methylpropanediol
Glycerin
Butylene Glycol
1,2-Hexanediol
Betaine
Pentylene Glycol
Carbomer
Caprylyl Glycol
Allantoin
Tromethamine
Ethylhexylglycerin
Xanthan Gum
Panthenol
Malachite Extract
Hydrolyzed Hyaluronic Acid
Disodium EDTA
Glyceryl Acrylate/Acrylic Acid Copolymer
Glyceryl Glucoside
Sodium Hyaluronate
Potassium Hyaluronate
Hyaluronic Acid
Hydrolyzed Sodium Hyaluronate
Sodium Acetylated Hyaluronate
Hydroxypropyltrimonium Hyaluronate
Sodium Hyaluronate Crosspolymer
Dimethylsilanol Hyaluronate
Hydrolyzed Calcium Hyaluronate
Sodium Sulfated Hyaluronate
Madecassoside
Beta-Glucan
Sodium Stearoyl Hyaluronate
Sodium Oleoyl Hyaluronate
Sea Water, Water, Methylpropanediol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Betaine, Pentylene Glycol, Carbomer, Caprylyl Glycol, Allantoin, Tromethamine, Ethylhexylglycerin, Xanthan Gum, Panthenol, Malachite Extract, Hydrolyzed Hyaluronic Acid, Disodium EDTA, Glyceryl Acrylate/Acrylic Acid Copolymer, Glyceryl Glucoside, Sodium Hyaluronate, Potassium Hyaluronate, Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Crosspolymer, Dimethylsilanol Hyaluronate, Hydrolyzed Calcium Hyaluronate, Sodium Sulfated Hyaluronate, Madecassoside, Beta-Glucan, Sodium Stearoyl Hyaluronate, Sodium Oleoyl Hyaluronate
Niacinamide
Tranexamic Acid
Centella Asiatica Extract
Zea Mays Starch
Microcrystalline Cellulose
Mannitol
Hydroxyethylcellulose
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Arginine
Hydrogenated Lecithin
Xylitylglucoside
Anhydroxylitol
Xylitol
Glucose
3-O-Ethyl Ascorbic Acid
Lactobacillus Ferment
Water, Butylene Glycol, Niacinamide, Glycerin, Tranexamic Acid, 1,2-Hexanediol, Betaine, Centella Asiatica Extract, Zea Mays Starch, Xanthan Gum, Microcrystalline Cellulose, Mannitol, Panthenol, Pentylene Glycol, Ethylhexylglycerin, Hydroxyethylcellulose, Madecassoside, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Arginine, Hydrogenated Lecithin, Xylitylglucoside, Anhydroxylitol, Xylitol, Glucose, 3-O-Ethyl Ascorbic Acid, Lactobacillus Ferment
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.
Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.
Some studies suggest betaine may support making skin tone more even.
Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.
Betaine is also known as trimethylglycine.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Madecassoside is one of four active compounds found in Centella asiatica and is one of the main reasons Centella is so effective at calming irritated skin and supporting the moisture barrier.
There's a solid body of peer-reviewed research backing Madecassoside for several skin benefits. Studies have found:
Madecassoside pairs well with other hydrating or antioxidant ingredients like Ascorbic Acid or Hyaluronic Acid.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.