Skin science article
Mad Hippie Corrective Peptide Serum Versus The Ordinary Multi-Peptide + HA Serum
Mad Hippie Corrective Peptide Serum Versus The Ordinary Multi-Peptide + HA Serum This anti-aging serum is formulated around Palmitoyl Tripeptide-38 and Ceramide NP to soften the look of wrinkles and strengthen the skin barrier. This anti-aging serum is formula
Mad Hippie Corrective Peptide Serum Versus The Ordinary Multi-Peptide + HA Serum
This anti-aging serum is formulated around Palmitoyl Tripeptide-38 and Ceramide NP to soften the look of wrinkles and strengthen the skin barrier.
This anti-aging serum is formulated around Lactococcus Ferment Lysate and Acetyl Hexapeptide-8 to soften the look of wrinkles and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Caprylic/Capric Triglyceride
Chenopodium Quinoa Seed Extract
Propanediol
Potassium Cetyl Phosphate
Acetyl Tetrapeptide-2
Sodium Hyaluronate
Apium Graveolens Seed Extract
Linum Usitatissimum Seed Extract
Hydroxypropyl Cyclodextrin
Palmitoyl Tripeptide-38
Tremella Fuciformis Polysaccharide
Squalane
Hydrolyzed Yeast Extract
Sorbitan Trioleate
Cetyl Hydroxyethylcellulose
Polyglucuronic Acid
Acetyl Tetrapeptide-22
Avena Sativa Meal Extract
Phenethyl Alcohol
Caprylyl Glycol
Ethylhexylglycerin
Stearyl Alcohol
Polyglutamic Acid
Hydroxyethylcellulose
Citrus Aurantium Dulcis Peel Oil
Lecithin
Ceramide NP
Tocopherol
Water, Glycerin, Caprylic/Capric Triglyceride, Chenopodium Quinoa Seed Extract, Propanediol, Potassium Cetyl Phosphate, Acetyl Tetrapeptide-2, Sodium Hyaluronate, Apium Graveolens Seed Extract, Linum Usitatissimum Seed Extract, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38, Tremella Fuciformis Polysaccharide, Squalane, Hydrolyzed Yeast Extract, Sorbitan Trioleate, Cetyl Hydroxyethylcellulose, Polyglucuronic Acid, Acetyl Tetrapeptide-22, Avena Sativa Meal Extract, Phenethyl Alcohol, Caprylyl Glycol, Ethylhexylglycerin, Stearyl Alcohol, Polyglutamic Acid, Hydroxyethylcellulose, Citrus Aurantium Dulcis Peel Oil, Lecithin, Ceramide NP, Tocopherol
Lactococcus Ferment Lysate
Acetyl Hexapeptide-8
Pentapeptide-18
Palmitoyl Tripeptide-1
Palmitoyl Tetrapeptide-7
Dipeptide Diaminobutyroyl Benzylamide Diacetate
Acetylarginyltryptophyl Diphenylglycine
Sodium Hyaluronate Crosspolymer
Allantoin
Glycine
Alanine
Serine
Valine
Isoleucine
Proline
Threonine
Histidine
Phenylalanine
Arginine
Aspartic Acid
Trehalose
Fructose
Glucose
Maltose
Urea
Sodium PCA
PCA
Sodium Lactate
Citric Acid
Sodium Chloride
Sodium Hydroxide
Butylene Glycol
Pentylene Glycol
Acacia Senegal Gum
Xanthan Gum
Carbomer
Polysorbate 20
PPG-26-Buteth-26
PEG-40 Hydrogenated Castor Oil
Trisodium Ethylenediamine Disuccinate
Ethoxydiglycol
Sodium Benzoate
Phenoxyethanol
Chlorphenesin
Water, Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
This ingredient is used in skincare as a delivery system.
It works by "encapsulating" active ingredients with its unique ring shape that is water-loving on the outside and oil-loving on the inside. This improves the stability and absorption of the product into the skin.
According to a manufacturer, it also offer some moisturizing effects.
This synthetic, signal peptide has unique skin conditioning properties in that is a matrikine-mimetic compound.
First of all, Palmitoyl Tripeptide-38 is a signal peptide; signal peptides tell the body to create more collagen.
What is a matrikine-mimetic compound?
This peptide has the ability to mimic matrikines in skin. Our skin created matrikines by breaking down matrix proteins into peptides.
Matrikines play a role in:
Though further research is needed, this ingredient seems pretty promising. In one study, women over the age of 40 with visible photoaging used a vitamin C serum with this ingredient for 56 days (15% ascorbid acid, 5 ppm palmitoyl tripeptide‐38). The results found improvement in skin roughness and skin tone.
This peptide is also part of the famous Matrixyl synthe’6, a blend of ingredients that also includes glycerin, water, and hydroxypropyl cyclodextrin.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!