Skin science article
MEDI-PEEL Hyaluron Cica Peptide 9 Ampoule Eye Patch Versus Mizon Hyaluronic Eye Gel Patch
MEDI-PEEL Hyaluron Cica Peptide 9 Ampoule Eye Patch Versus Mizon Hyaluronic Eye Gel Patch This hydrating eye mask is formulated around Centella Asiatica Extract and Sodium Hyaluronate to hydrate skin and soften the look of wrinkles. This hydrating eye mask is
MEDI-PEEL Hyaluron Cica Peptide 9 Ampoule Eye Patch Versus Mizon Hyaluronic Eye Gel Patch
This hydrating eye mask is formulated around Centella Asiatica Extract and Sodium Hyaluronate to hydrate skin and soften the look of wrinkles.
This hydrating eye mask is formulated around Chondrus Crispus Extract and Allantoin to hydrate skin and calm redness.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Carrageenan
Butylene Glycol
Centella Asiatica Extract
Lavandula Angustifolia Extract
Monarda Didyma Leaf Extract
Mentha Piperita Leaf Extract
Freesia Refracta Extract
Chamomilla Recutita Flower Extract
Rosmarinus Officinalis Leaf Extract
Aloe Barbadensis Leaf Extract
Maltodextrin
Asiatic Acid
Asiaticoside
Madecassic Acid
Hydrolyzed Collagen
Sodium Hyaluronate
Ethylhexylglycerin
Hydrolyzed Hyaluronic Acid
Sodium Acetylated Hyaluronate
Hydroxypropyltrimonium Hyaluronate
Potassium Hyaluronate
Sodium Hyaluronate Crosspolymer
Hyaluronic Acid
Glyceryl Polymethacrylate
Propylene Glycol
Palmitoyl Oligopeptide
Palmitoyl Tripeptide-1
Palmitoyl Tetrapeptide-7
Palmitoyl Tripeptide-5
Acetyl Hexapeptide-8
Copper Tripeptide-1
Oligopeptide-29
Oligopeptide-32
Palmitoyl Pentapeptide-4
Propanediol
Pentylene Glycol
Cocos Nucifera Fruit Extract
Pinus Sylvestris Leaf Extract
Ceratonia Siliqua Gum
Sucrose
Potassium Chloride
Cyamopsis Tetragonoloba Gum
Cellulose Gum
Allantoin
Betaine
Dipotassium Glycyrrhizate
Calcium Lactate
Calcium Chloride
Ricinus Communis Seed Oil
Butyrospermum Parkii Butter
PEG-60 Hydrogenated Castor Oil
Sorbitan Caprylate
Caprylic/Capric Triglyceride
Chromium Oxide Greens
Synthetic Fluorphlogopite
Titanium Dioxide
Arginine
Disodium EDTA
Ethyl Hexanediol
1,2-Hexanediol
Chlorphenesin
Parfum
Water, Glycerin, Carrageenan, Butylene Glycol, Centella Asiatica Extract, Lavandula Angustifolia Extract, Monarda Didyma Leaf Extract, Mentha Piperita Leaf Extract, Freesia Refracta Extract, Chamomilla Recutita Flower Extract, Rosmarinus Officinalis Leaf Extract, Aloe Barbadensis Leaf Extract, Maltodextrin, Asiatic Acid, Asiaticoside, Madecassic Acid, Hydrolyzed Collagen, Sodium Hyaluronate, Ethylhexylglycerin, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Potassium Hyaluronate, Sodium Hyaluronate Crosspolymer, Hyaluronic Acid, Glyceryl Polymethacrylate, Propylene Glycol, Palmitoyl Oligopeptide, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Copper Tripeptide-1, Oligopeptide-29, Oligopeptide-32, Palmitoyl Pentapeptide-4, Propanediol, Pentylene Glycol, Cocos Nucifera Fruit Extract, Pinus Sylvestris Leaf Extract, Ceratonia Siliqua Gum, Sucrose, Potassium Chloride, Cyamopsis Tetragonoloba Gum, Cellulose Gum, Allantoin, Betaine, Dipotassium Glycyrrhizate, Calcium Lactate, Calcium Chloride, Ricinus Communis Seed Oil, Butyrospermum Parkii Butter, PEG-60 Hydrogenated Castor Oil, Sorbitan Caprylate, Caprylic/Capric Triglyceride, Chromium Oxide Greens, Synthetic Fluorphlogopite, Titanium Dioxide, Arginine, Disodium EDTA, Ethyl Hexanediol, 1,2-Hexanediol, Chlorphenesin, Parfum
Chondrus Crispus Extract
Hydroxyacetophenone
Xanthan Gum
Calcium Aluminum Borosilicate
Bis-PEG-15 Methyl Ether Dimethicone
CI 77891
Silica
Enteromorpha Compressa Extract
Gelidium Amansii Extract
Kjellmaniella Gyrata Extract
Sargassum Fusiforme Extract
Laminaria Japonica Extract
Mica
Sodium Polyacryloyldimethyl Taurate
Polyglyceryl-6 Caprylate
Polyglyceryl-4 Caprate
Phenoxyethanol
CI 42090
Tocopherol
CI 19140
Water, Glycerin, Chondrus Crispus Extract, Ceratonia Siliqua Gum, Cellulose Gum, Hydroxyacetophenone, 1,2-Hexanediol, Sucrose, Potassium Chloride, Allantoin, Xanthan Gum, Ethylhexylglycerin, Calcium Aluminum Borosilicate, Bis-PEG-15 Methyl Ether Dimethicone, Butylene Glycol, Disodium EDTA, Calcium Lactate, CI 77891, Silica, Enteromorpha Compressa Extract, Gelidium Amansii Extract, Kjellmaniella Gyrata Extract, Sargassum Fusiforme Extract, Laminaria Japonica Extract, Mica, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Sodium Polyacryloyldimethyl Taurate, Polyglyceryl-6 Caprylate, Polyglyceryl-4 Caprate, PEG-60 Hydrogenated Castor Oil, Parfum, Phenoxyethanol, CI 42090, Tocopherol, CI 19140, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.
Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.
Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.
It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.
Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.
This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.
Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.
Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Calcium Lactate is created by combining lactic acid with calcium carbonate or calcium hydroxide.
Cellulose Gum is a water-soluble polymer that comes from cellulose. It is used to change the texture of a product and to help stabilize emulsions.
As an emulsifier, cellulose gum specifically thicken the texture of water-based products.
This ingredient is considered hypoallergenic and non-toxic. Cellulose Gum can be found in cosmetics, food, and other household goods such as paper products.
Ceratonia Siliqua Gum is extracted from the seeds of the carob tree. You might know this ingredient as Carob Gum or Locust Bean Gum. It is used to stabilize other ingredients and improve the texture of products.
Carob gum is made up of long-chain polysaccharides. This makes it a natural thickener.
Yes! This ingredient comes from the seeds of a tree. The name 'Locust Bean Gum' can be misleading.
Dipotassium Glycyrrhizate comes from licorice root.
Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.
One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.
Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.
Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.
Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.
Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.
Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.
The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
This is why the best HA serums blend the two sizes together so you get the best of both worlds.
The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.
A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.
These are some other common types of Hyaluronic Acid:
Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.
It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.
Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.
Most formulations will combine all sizes to get the best of both worlds.
Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.
Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Peg-60 Hydrogenated Castor Oil comes from hydrogenated castor oil. It is a solubilizer and emulsifier.
As a solubilizer, it helps dissolve ingredients into a water-based version. It is also an emulsifer. Emulsifier help prevent oils and water from separating. Both these properties help create evenly-spread and uniform products.
Basically, Peg-60 Hydrogenated Castor Oil helps hold ingredients together.
We don't have a description for Potassium Chloride yet.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sucrose is a natural sugar found in fruits, vegetables, and nuts. It is the main constituent of white sugar.
In skincare, sucrose is a humectant and can be a mild exfoliant.
Sucrose is hydrophilic, meaning it attracts water. This makes it an effective humectant and helps hydrate the skin.
Studies show sugars may worsen acne-prone skin due to it disrupting the skin's natural biome. We recommend speaking with a professional if you have any concerns.
In some products such as body scrubs, sucrose is used as an gentle exfoliant.
The term 'sucrose' comes from the french word for sugar, 'sucre'.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!