Skin science article
MediCube PDRN Pink Peptide Serum Versus Anua Niacinamide 10% + TXA 4% Dark Spot Correcting Serum
MediCube PDRN Pink Peptide Serum Versus Anua Niacinamide 10% + TXA 4% Dark Spot Correcting Serum This anti-aging serum is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles and refine skin texture. This brightening serum is formulated
MediCube PDRN Pink Peptide Serum Versus Anua Niacinamide 10% + TXA 4% Dark Spot Correcting Serum
This anti-aging serum is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles and refine skin texture.
This brightening serum is formulated around Niacinamide and Tranexamic Acid to fade the look of dark spots and brighten dull-looking skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Dipropylene Glycol
Isopropyl Myristate
Glycereth-26
Niacinamide
1,2-Hexanediol
Sodium DNA
Butylene Glycol
Polyglycerin-3
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Polyisobutene
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Milt Extract
Tromethamine
Glyceryl Acrylate/Acrylic Acid Copolymer
Pvm/Ma Copolymer
Ethylhexylglycerin
Caprylyl Glycol
Parfum
Melia Azadirachta Leaf Extract
Adenosine
Caprylyl/Capryl Glucoside
Sorbitan Oleate
Melia Azadirachta Flower Extract
Sodium Hyaluronate
Disodium EDTA
Curcuma Longa Root Extract
Cyanocobalamin
Hydrolyzed Collagen
Ubiquinone
Ocimum Sanctum Leaf Extract
Corallina Officinalis Extract
Palmitoyl Pentapeptide-4
Palmitoyl Tripeptide-1
Palmitoyl Tetrapeptide-7
Copper Tripeptide-1
Acetyl Hexapeptide-8
Salmon Egg Extract
Atelocollagen
Water, Glycerin, Dipropylene Glycol, Isopropyl Myristate, Glycereth-26, Niacinamide, 1,2-Hexanediol, Sodium DNA, Butylene Glycol, Polyglycerin-3, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polyisobutene, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Milt Extract, Tromethamine, Glyceryl Acrylate/Acrylic Acid Copolymer, Pvm/Ma Copolymer, Ethylhexylglycerin, Caprylyl Glycol, Parfum, Melia Azadirachta Leaf Extract, Adenosine, Caprylyl/Capryl Glucoside, Sorbitan Oleate, Melia Azadirachta Flower Extract, Sodium Hyaluronate, Disodium EDTA, Curcuma Longa Root Extract, Cyanocobalamin, Hydrolyzed Collagen, Ubiquinone, Ocimum Sanctum Leaf Extract, Corallina Officinalis Extract, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Copper Tripeptide-1, Acetyl Hexapeptide-8, Salmon Egg Extract, Atelocollagen
Tranexamic Acid
Diethoxyethyl Succinate
Arbutin
Alpha-Arbutin
Coccinia Indica Fruit Extract
Eclipta Prostrata Extract
Macadamia Integrifolia Seed Oil
Olea Europaea Fruit Oil
Simmondsia Chinensis Seed Oil
Vitis Vinifera Seed Oil
Theobroma Cacao Extract
Hydrolyzed Hyaluronic Acid
Chamaecyparis Obtusa Leaf Extract
Prunus Persica Flower Extract
Camellia Sinensis Seed Oil
Yeast Ferment Extract
Centella Asiatica Extract
Artemisia Princeps Leaf Extract
Glucose
Hyaluronic Acid
Pentylene Glycol
Betaine Salicylate
Sucrose Palmitate
Hydrogenated Lecithin
Gellan Gum
Sodium Phytate
Cellulose
Caprylic/Capric Triglyceride
Panthenol
Polyglutamic Acid
3-O-Ethyl Ascorbic Acid
Ceramide NP
Dextrin
Asiaticoside
Madecassic Acid
Asiatic Acid
Dimethylsilanol Hyaluronate
Hydrolyzed Sodium Hyaluronate
Potassium Hyaluronate
Hydroxypropyltrimonium Hyaluronate
Sodium Hyaluronate Crosspolymer
Sodium Hyaluronate Dimethylsilanol
Sodium Acetylated Hyaluronate
Xanthan Gum
Water, Glycerin, Niacinamide, Tranexamic Acid, Butylene Glycol, Diethoxyethyl Succinate, 1,2-Hexanediol, Arbutin, Sodium Hyaluronate, Alpha-Arbutin, Coccinia Indica Fruit Extract, Eclipta Prostrata Extract, Macadamia Integrifolia Seed Oil, Olea Europaea Fruit Oil, Simmondsia Chinensis Seed Oil, Vitis Vinifera Seed Oil, Theobroma Cacao Extract, Hydrolyzed Hyaluronic Acid, Chamaecyparis Obtusa Leaf Extract, Prunus Persica Flower Extract, Camellia Sinensis Seed Oil, Yeast Ferment Extract, Centella Asiatica Extract, Artemisia Princeps Leaf Extract, Glucose, Hyaluronic Acid, Pentylene Glycol, Betaine Salicylate, Sucrose Palmitate, Hydrogenated Lecithin, Gellan Gum, Sodium Phytate, Cellulose, Caprylic/Capric Triglyceride, Panthenol, Cyanocobalamin, Polyglutamic Acid, 3-O-Ethyl Ascorbic Acid, Ceramide NP, Dextrin, Asiaticoside, Madecassic Acid, Asiatic Acid, Dimethylsilanol Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate Dimethylsilanol, Sodium Acetylated Hyaluronate, Xanthan Gum
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Cyanocobalamin is the manufactured version of vitamin B12. It has skin soothing, antioxidant, and barrier protecting properties. Topical cyanocobalamin is used to treat skin irritation and atopic dermatitis.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!