Skin science article
MediCube Zero Pore One-Day Cream Versus Beauty of Joseon Dynasty Cream
MediCube Zero Pore One-Day Cream Versus Beauty of Joseon Dynasty Cream This pore-care moisturizer is formulated around Panthenol and Niacinamide to refine the look of pores and refine skin texture. This barrier-repair moisturizer is formulated around Panax Gin
MediCube Zero Pore One-Day Cream Versus Beauty of Joseon Dynasty Cream
This pore-care moisturizer is formulated around Panthenol and Niacinamide to refine the look of pores and refine skin texture.
This barrier-repair moisturizer is formulated around Panax Ginseng Root Water and Niacinamide to strengthen the skin barrier.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Panthenol
Butylene Glycol
Propanediol
Cetyl Ethylhexanoate
Octyldodecanol
Niacinamide
Isohexadecane
Isododecane
Glyceryl Stearate
Polyglyceryl-3 Distearate
1,2-Hexanediol
Hydrogenated Poly(C6-14 Olefin)
Dimethicone
Cyclopentasiloxane
Cetearyl Olivate
Sorbitan Olivate
Stearyl Alcohol
Dimethyl Sulfone
Cetyl Alcohol
Polyacrylate-13
Sodium Polyacryloyldimethyl Taurate
Sodium Stearoyl Glutamate
Hydrogenated Polyisobutene
Glyceryl Stearate Citrate
Salicylic Acid
Ethylhexylglycerin
Allantoin
Polyglyceryl-10 Laurate
Ethylhexyl Palmitate
Adenosine
Dextrin
Sorbitan Isostearate
Tromethamine
Beta-Glucan
Sodium Hyaluronate
Glycerin
Sodium Citrate
Gardenia Florida Fruit Extract
Myristyl Alcohol
Trisodium Phosphate
Hyaluronic Acid
Pullulan
Lauryl Alcohol
Vitis Vinifera Fruit Extract
Ulmus Davidiana Root Extract
Pueraria Lobata Root Extract
Pinus Palustris Leaf Extract
Oenothera Biennis Flower Extract
Diospyros Kaki Fruit Extract
Castanea Crenata Shell Extract
Camellia Sinensis Leaf Extract
Sodium Hyaluronate Crosspolymer
Hydrolyzed Sodium Hyaluronate
Hydrolyzed Hyaluronic Acid
Palmitoyl Tripeptide-5
Sodium Acetylated Hyaluronate
Hydroxypropyltrimonium Hyaluronate
Hydroxycinnamic Acid
Rutin
Parfum
Water, Panthenol, Butylene Glycol, Propanediol, Cetyl Ethylhexanoate, Octyldodecanol, Niacinamide, Isohexadecane, Isododecane, Glyceryl Stearate, Polyglyceryl-3 Distearate, 1,2-Hexanediol, Hydrogenated Poly(C6-14 Olefin), Dimethicone, Cyclopentasiloxane, Cetearyl Olivate, Sorbitan Olivate, Stearyl Alcohol, Dimethyl Sulfone, Cetyl Alcohol, Polyacrylate-13, Sodium Polyacryloyldimethyl Taurate, Sodium Stearoyl Glutamate, Hydrogenated Polyisobutene, Glyceryl Stearate Citrate, Salicylic Acid, Ethylhexylglycerin, Allantoin, Polyglyceryl-10 Laurate, Ethylhexyl Palmitate, Adenosine, Dextrin, Sorbitan Isostearate, Tromethamine, Beta-Glucan, Sodium Hyaluronate, Glycerin, Sodium Citrate, Gardenia Florida Fruit Extract, Myristyl Alcohol, Trisodium Phosphate, Hyaluronic Acid, Pullulan, Lauryl Alcohol, Vitis Vinifera Fruit Extract, Ulmus Davidiana Root Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis Flower Extract, Diospyros Kaki Fruit Extract, Castanea Crenata Shell Extract, Camellia Sinensis Leaf Extract, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Palmitoyl Tripeptide-5, Sodium Acetylated Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Hydroxycinnamic Acid, Rutin, Parfum
Oryza Sativa Bran Water
Panax Ginseng Root Water
Hydrogenated Polydecene
Squalane
Propylene Glycol Dicaprylate/Dicaprate
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Xanthan Gum
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Carthamus Tinctorius Seed Oil
Hydrogenated Coconut Oil
Glyceryl Acrylate/Acrylic Acid Copolymer
Caprylic/Capric Triglyceride
Disodium EDTA
Honey Extract
Ceramide NP
Hydrogenated Lecithin
Coptis Japonica Root Extract
Raphanus Sativus Seed Extract
Lycium Chinense Fruit Extract
Theobroma Cacao Seed Extract
Phellinus Linteus Extract
Scutellaria Baicalensis Root Extract
Water, Oryza Sativa Bran Water, Glycerin, Panax Ginseng Root Water, Hydrogenated Polydecene, 1,2-Hexanediol, Niacinamide, Squalane, Butylene Glycol, Propanediol, Propylene Glycol Dicaprylate/Dicaprate, Cetearyl Olivate, Sorbitan Olivate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Carthamus Tinctorius Seed Oil, Hydrogenated Coconut Oil, Glyceryl Acrylate/Acrylic Acid Copolymer, Ethylhexylglycerin, Adenosine, Caprylic/Capric Triglyceride, Disodium EDTA, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Honey Extract, Ceramide NP, Hydrogenated Lecithin, Coptis Japonica Root Extract, Raphanus Sativus Seed Extract, Lycium Chinense Fruit Extract, Theobroma Cacao Seed Extract, Phellinus Linteus Extract, Dextrin, Scutellaria Baicalensis Root Extract
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Cetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable.
You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum.
These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin.
This ingredient is well-tolerated and has no significant sensitization data.
Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe.
Dextrin is a starch-derived polysaccharide. It's made by partially breaking down corn, potato, or other plant starches.
Think of it as "half-processed" starch; it's less complex than the original but not fully broken down into sugar like maltodextrin.
In cosmetics, it mainly functions as a bulking agent, viscosity controller, binder, and absorbent. It helps thicken products, stabilize powders, and get certain textures a less "wet" feel.
This ingredient has a pretty solid safety profile; it's recognized as a safe food additive and its large molecular size means it doesn't meaningfully penetrate skin.
Human repeat insult patch tests using a rinse-off facial product containing 42.69% dextrin found no skin irritation or sensitization in 54 subjects.
Typical real-world usage is much lower: usually under 1% as a texture modifier and up to 40% in masks (rinse off products use less).
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.
Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.
The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
This is why the best HA serums blend the two sizes together so you get the best of both worlds.
The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.
A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.
These are some other common types of Hyaluronic Acid:
Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.
It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.
Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.
Most formulations will combine all sizes to get the best of both worlds.
Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.
This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.
This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.
According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.
Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.
Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.
Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.
It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.
This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.
Concentration use ranges from 0.1-1.0% depending on the formula.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!