Missha Time Revolution Prismestem100 Lifting Serum Versus Hanskin Collagen Peptide Hydra Ampoule

Missha Time Revolution Prismestem100 Lifting Serum Versus Hanskin Collagen Peptide Hydra Ampoule

This anti-aging serum is formulated around Niacinamide and Adenosine to soften the look of wrinkles.

This anti-aging ampoule is formulated around Collagen Extract and Niacinamide to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Methylpropanediol

Glycerin

Betaine

Glycereth-26

Methyl Gluceth-20

Niacinamide

Pentylene Glycol

Helichrysum Italicum Flower Water

Chondrus Crispus Extract

Xylitylglucoside

Polyglyceryl-10 Laurate

Saccharum Officinarum Extract

Anhydroxylitol

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Angelica Archangelica Callus Extract

Tromethamine

1,2-Hexanediol

Xylitol

Butylene Glycol

Xanthan Gum

Ethylhexylglycerin

Octanediol

Adenosine

Parfum

Biosaccharide Gum-1

Hydrolyzed Hyaluronic Acid

Sodium Phytate

Coccinia Indica Fruit Extract

Eclipta Prostrata Extract

Dextrin

Theobroma Cacao Seed Extract

Beta-Glucan

Tocopherol

Hydroxystearic Acid

Limnanthes Alba Seed Oil

Maltodextrin

Dipropylene Glycol

Hydrogenated Lecithin

Polyglyceryl-10 Oleate

Polyglyceryl-3 Methylglucose Distearate

Swertia Chirata Extract

Choleth-24

Ceramide NP

Water, Methylpropanediol, Glycerin, Betaine, Glycereth-26, Methyl Gluceth-20, Niacinamide, Pentylene Glycol, Helichrysum Italicum Flower Water, Chondrus Crispus Extract, Xylitylglucoside, Polyglyceryl-10 Laurate, Saccharum Officinarum Extract, Anhydroxylitol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Angelica Archangelica Callus Extract, Tromethamine, 1,2-Hexanediol, Xylitol, Butylene Glycol, Xanthan Gum, Ethylhexylglycerin, Octanediol, Adenosine, Parfum, Biosaccharide Gum-1, Hydrolyzed Hyaluronic Acid, Sodium Phytate, Coccinia Indica Fruit Extract, Eclipta Prostrata Extract, Dextrin, Theobroma Cacao Seed Extract, Beta-Glucan, Tocopherol, Hydroxystearic Acid, Limnanthes Alba Seed Oil, Maltodextrin, Dipropylene Glycol, Hydrogenated Lecithin, Polyglyceryl-10 Oleate, Polyglyceryl-3 Methylglucose Distearate, Swertia Chirata Extract, Choleth-24, Ceramide NP

Collagen Extract

Acetyl Hexapeptide-8

Copper Tripeptide-1

Oligopeptide-29

Oligopeptide-32

Palmitoyl Pentapeptide-4

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-5

Octapeptide-7

Sh-Decapeptide-7

Sh-Octapeptide-4

Sh-Oligopeptide-9

Sh-Pentapeptide-19

Pentapeptide-18

Acetyl Tetrapeptide-5

Sh-Oligopeptide-1

Sh-Oligopeptide-2

Sh-Polypeptide-1

Sh-Polypeptide-22

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Hydrolyzed Elastin

Hydrolyzed Collagen

Sodium Hyaluronate

Sodium Acetylated Hyaluronate

Hydroxypropyltrimonium Hyaluronate

Sodium Hyaluronate Crosspolymer

Hyaluronic Acid

Potassium Hyaluronate

Hydrolyzed Extensin

Isostearic Acid

Sucrose Stearate

Phytosteryl/Octyldodecyl Lauroyl Glutamate

Octyldodecanol

Sodium Stearoyl Glutamate

Squalane

Caprylic/Capric Glycerides

Cyclodextrin

Cocos Nucifera Fruit Extract

Pinus Sylvestris Leaf Extract

Propanediol

Caprylyl Glycol

Caprylic/Capric Triglyceride

Arginine

Chlorphenesin

Sodium Polyacrylate

Disodium EDTA

Collagen Extract, Glycerin, Butylene Glycol, Niacinamide, Betaine, Glycereth-26, Acetyl Hexapeptide-8, Copper Tripeptide-1, Oligopeptide-29, Oligopeptide-32, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, Octapeptide-7, Sh-Decapeptide-7, Sh-Octapeptide-4, Sh-Oligopeptide-9, Sh-Pentapeptide-19, Pentapeptide-18, Acetyl Tetrapeptide-5, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-22, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Hydrolyzed Elastin, Hydrolyzed Collagen, Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Crosspolymer, Hyaluronic Acid, Potassium Hyaluronate, Hydrolyzed Extensin, Isostearic Acid, Sucrose Stearate, Phytosteryl/Octyldodecyl Lauroyl Glutamate, Octyldodecanol, Sodium Stearoyl Glutamate, 1,2-Hexanediol, Ceramide NP, Squalane, Caprylic/Capric Glycerides, Xylitylglucoside, Anhydroxylitol, Xylitol, Water, Dextrin, Cyclodextrin, Pentylene Glycol, Cocos Nucifera Fruit Extract, Pinus Sylvestris Leaf Extract, Polyglyceryl-10 Laurate, Propanediol, Caprylyl Glycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylic/Capric Triglyceride, Arginine, Chlorphenesin, Xanthan Gum, Adenosine, Sodium Polyacrylate, Disodium EDTA, Ethylhexylglycerin

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

This ingredient is created from dehydrating xylitol in acidic conditions. Xylitol is a famous sugar and humectant.

Much like its predecessor, anhydroxylitol is a humectant. Humectants attract and hold water to moisturize the skin.

This ingredient is most commonly found in a popular trio called Aquaxyl. Aquaxyl is made up of anhydroxylitol (24 - 34%), xylitylglucoside (35 - 50%), and xylitol (5 - 15%).

According to a manufacturer, Aquaxyl is known for a 3-D hydration concept and an anti-dehydration shield to reinforce the outer layer of skin.

This ingredient is often derived from plants such as wood and sugarcane.

Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.

Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.

Some studies suggest betaine may support making skin tone more even.

Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.

Betaine is also known as trimethylglycine.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Dextrin is a starch-derived polysaccharide. It's made by partially breaking down corn, potato, or other plant starches.

Think of it as "half-processed" starch; it's less complex than the original but not fully broken down into sugar like maltodextrin.

In cosmetics, it mainly functions as a bulking agent, viscosity controller, binder, and absorbent. It helps thicken products, stabilize powders, and get certain textures a less "wet" feel.

This ingredient has a pretty solid safety profile; it's recognized as a safe food additive and its large molecular size means it doesn't meaningfully penetrate skin.

Human repeat insult patch tests using a rinse-off facial product containing 42.69% dextrin found no skin irritation or sensitization in 54 subjects.

Typical real-world usage is much lower: usually under 1% as a texture modifier and up to 40% in masks (rinse off products use less).

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycereth-26 is a synthetic ingredient and polyethylene glycol ether of Glycerin. Glycerin is already naturally found in your skin and helps keep your skin moisturized.

It is a humectant and helps add texture to products. It can make your product thicker.

As a humectant, it helps draw moisture from the air to your skin. This helps your skin stay hydrated.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Polyglyceryl-10 Laurate is a cleansing agent and emulsifier.

It rounds up dirt, oil, and grime, so they can be rinsed off easily as a cleanser.

On the emulsifier side, it keeps your formula smooth and well-mixed by playing peacekeeper for ingredients that don't naturally get along (like oil and water).

Because it has a C12 (lauric acid) fatty acid chain, this ingredient can potentially feed the Malassezia yeast that causes fungal acne. The Malassezia yeast prefers esters with C11-C24 fatty acids.

This ingredient is an ester of lauric acid and Polyglycerin-10.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Xylitol is a humectant and prebiotic. It can help with dry skin.

In studies, xylitol has been shown to improve dry skin. It decreased transepidermal water loss, or when water passes through the skin and evaporates. Xylitol also showed to help improve the biomechanical properties of the skin barrier.

The prebiotic property of xylitol may also help reinforce our skin's natural microbiome. Having a healthy microbiome prevents infection by bad bacteria and helps with hydration.

As a humectant, Xylitol helps draw moisture from both the air and from deeper skin layers. This helps keep skin hydrated.

Xylitol is a sugar alcohol and commonly used as a sugar substitute. It is naturally occurring in plants such as strawberries and pumpkin.

Xylitylglucoside is created from xylitol and glucose, two humectants.

Not surprisingly, this ingredient is also a humectant. It attracts and holds water in your skin, helping to maintain hydration.

This ingredient is most commonly found in a popular trio called Aquaxyl. Aquaxyl is made up of anhydroxylitol(24 - 34%), xylitylglucoside (35 - 50%), and xylitol (5 - 15%).

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