Natio Plant Peptide Line & Wrinkle Serum Versus Glow Recipe Avocado Ceramide Recovery Serum

Natio Plant Peptide Line & Wrinkle Serum Versus Glow Recipe Avocado Ceramide Recovery Serum

This anti-aging serum is formulated around Ceramide NP to soften the look of wrinkles and strengthen the skin barrier.

This barrier-repair serum is formulated around Persea Gratissima Oil and Niacinamide to strengthen the skin barrier and calm redness.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Caprylic/Capric Triglyceride

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Ceramide NP

Ceramide Ns

Ceramide Eos

Ceramide EOP

Ceramide AP

Cholesterol

Caprooyl Phytosphingosine

Caprooyl Sphingosine

Ceteareth-25

Cetyl Alcohol

Behenic Acid

Hydrolyzed Hazelnut Protein

Tocopheryl Acetate

Disodium EDTA

BHT

Caprylyl Glycol

Phenoxyethanol

Water, Glycerin, Caprylic/Capric Triglyceride, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Ceramide NP, Ceramide Ns, Ceramide Eos, Ceramide EOP, Ceramide AP, Cholesterol, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Ceteareth-25, Cetyl Alcohol, Behenic Acid, Hydrolyzed Hazelnut Protein, Tocopheryl Acetate, Disodium EDTA, BHT, Caprylyl Glycol, Phenoxyethanol

Jojoba Esters

Persea Gratissima Oil

Persea Gratissima Fruit Extract

Niacinamide

Hydrolyzed Rice Protein

Allantoin

Oryza Sativa Bran Oil

Bisabolol

Zingiber Officinale Root Extract

Curcuma Longa Root Extract

Tocopherol

Palmitoyl Tripeptide-8

Vitis Vinifera Fruit Extract

Potassium Palmitoyl Hydrolyzed Wheat Protein

Boswellia Serrata Extract

Populus Tremuloides Bark Extract

Sodium Phytate

Melia Azadirachta Flower Extract

Melia Azadirachta Leaf Extract

Ocimum Sanctum Leaf Extract

Ethylhexylglycerin

Ocimum Basilicum Flower/Leaf Extract

Elettaria Cardamomum Seed Extract

Jasminum Officinale Flower/Leaf Extract

Corallina Officinalis Extract

Sodium Carbonate

Sodium Chloride

CI 75810

Camellia Sinensis Leaf Extract

Cananga Odorata Flower Extract

Cucumis Melo Fruit Extract

Cucumis Sativus Fruit Extract

Pyrus Malus Fruit Extract

Rose Extract

Rubus Idaeus Leaf Extract

Ascorbyl Palmitate

Dextran

Hydroxyacetophenone

Xanthan Gum

Butylene Glycol

Carbomer

Cetearyl Olivate

Sorbitan Olivate

1,2-Hexanediol

Hydrogenated Vegetable Oil

Lavandula Angustifolia Flower/Leaf/Stem Extract

Santalum Album Wood Extract

Sodium Hydroxide

Sodium Benzoate

Water, Glycerin, Jojoba Esters, Persea Gratissima Oil, Persea Gratissima Fruit Extract, Niacinamide, Ceramide NP, Ceramide Ns, Ceramide AP, Ceramide EOP, Ceramide Eos, Hydrolyzed Rice Protein, Allantoin, Oryza Sativa Bran Oil, Bisabolol, Zingiber Officinale Root Extract, Curcuma Longa Root Extract, Tocopherol, Palmitoyl Tripeptide-8, Vitis Vinifera Fruit Extract, Potassium Palmitoyl Hydrolyzed Wheat Protein, Boswellia Serrata Extract, Populus Tremuloides Bark Extract, Caprylic/Capric Triglyceride, Sodium Phytate, Cetyl Alcohol, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Ocimum Sanctum Leaf Extract, Behenic Acid, Cholesterol, Ethylhexylglycerin, Ocimum Basilicum Flower/Leaf Extract, Elettaria Cardamomum Seed Extract, Jasminum Officinale Flower/Leaf Extract, Corallina Officinalis Extract, Sodium Carbonate, Sodium Chloride, CI 75810, Camellia Sinensis Leaf Extract, Cananga Odorata Flower Extract, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Cucumis Melo Fruit Extract, Cucumis Sativus Fruit Extract, Pyrus Malus Fruit Extract, Rose Extract, Rubus Idaeus Leaf Extract, Ascorbyl Palmitate, Dextran, Hydroxyacetophenone, Xanthan Gum, Butylene Glycol, Carbomer, Cetearyl Olivate, Sorbitan Olivate, 1,2-Hexanediol, Caprylyl Glycol, Hydrogenated Vegetable Oil, Lavandula Angustifolia Flower/Leaf/Stem Extract, Santalum Album Wood Extract, Tocopheryl Acetate, Ceteareth-25, Sodium Hydroxide, Phenoxyethanol, Sodium Benzoate

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Behenic acid is a long-chain fatty acid with 22 carbon atoms (C22) that is naturally found in moringa, rapeseed, and peanut oil.

In skincare, it's about as drama-free as ingredients come. It acts primarily as a texture enhancer, thickener, and opacifying agent that gives richness and viscosity to formulas.

On skin, it forms a protective, emollient layer that helps with moisture retention and contributes to barrier integrity.

In vitro studies on genotoxicity have come back negative and this ingredient is well-tolerated. Typical use concentrations range from 0.024%-22%.

This ingredient may not be fungal acne safe because Behenic acid falls within the C11-24 fatty acid range capable of supporting Malassezia growth.

This ceramide helps condition and moisturize skin.

It is created by reacting caproic acid and phytosphingosine, two fatty acids.

Ceramides work to improve hydration from within. Their lipophilic trait means they are likely to be absorbed into skin but expected to remain in the epidermis (the outer layer of skin).

We don't have a description for Caprooyl Sphingosine yet.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ceramide AP is is a skin-identical lipid that mimics what your skin already makes naturally. Ceramides help maintain epidermal integrity and barrier function.

You'll often see this ingredient paired with other ceramides (like ceramide NP), cholesterol, or fatty acids because this combination best mimics the natural lipid mix your skin already has.

The skin's ability to produce ceramides gets disrupted in skin conditions like eczema. This in turn weakens the skin barrier and applying ceramides topically has been shown to replenish what's been lost to restore barrier function.

Most of the studies with Ceramide AP test it as part of a multi-ceramide complex; studies reinforce ceramide AP's role in rebalancing ceramides in skin and improving skin hydration.

Ceramide EOP is formally known as Ceramide 1.

It is naturally found in skin and part of the intercellular "mortar" holding everything together in your outermost layer.

EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.

What makes Ceramide EOP special is its ultra-long fatty acid chain; this unique structure allows it to bridge the lipid layers in your skin barrier to prevent water loss (something no other ceramide can do).

Low levels of Ceramide EOP have been found in people with eczema and psoriasis.

Using it together with other ceramides, cholesterol, and linoleic acid have been shown to meaningfully improve hydration and reduce water loss.

In one clinical study, a regimen using Ceramide EOP, NP, and AP led to significant symptom improvements in patients with eczema, psoriasis, and dry skin in just 4 weeks.

You'll usually see concentrations between 0.1-0.5% in formulations. Overall, this is a well-tolerated and safe ingredient for cosmetic use.

Ceramide EOS is a type of Ceramide.

Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.

Ceramide EOS is a synthetic N-acylated sphingolipid consisting of Sphingosine having the D-erythro structure linked to an esterified omega-hydroxy saturated or unsaturated fatty acid

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Ceramide NS is formally known as Ceramide 2. It is one of the major ceramides in the stratum corneum (outermost layer of skin) plays a role in forming a protective barrier.

Due to its structure, skin lipids can be packed tightly and in turn, this strengthens the barrier and reduces water loss.

Studies show conditions like atopic dermatitis can worsen when ceramide NS levels are low.

Ceteareth-25 comes from Cetearyl Alcohol. (And Cetearyl Alcohol is created from cetyl alcohol and stearyl alcohol.

This ingredient is a fatty alcohol used as an emulsifier and surfactant. As an emulsifier, it helps oil mix with water.

Like cetearyl alcohol, Ceteareth-25 can help thicken and create a gel-like consistency.

Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.

Its main roles are:

Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.

Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.

It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).

This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.

Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.

Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.

Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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