Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Necessaire The Neck Serum Versus Allies of Skin Multi Peptides & GF Advanced Lifting Serum

Necessaire The Neck Serum Versus Allies of Skin Multi Peptides & GF Advanced Lifting Serum This anti-aging serum is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture. This anti-aging serum is formulat

Necessaire The Neck Serum Versus Allies of Skin Multi Peptides & GF Advanced Lifting Serum

This anti-aging serum is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture.

This anti-aging serum is formulated around Sh-Oligopeptide-1 and Dipeptide Diaminobutyroyl Benzylamide Diacetate to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Propanediol

Dicaprylyl Carbonate

Squalane

Coconut Alkanes

Cetearyl Olivate

Rosa Damascena Flower Water

Sorbitan Olivate

Niacinamide

Acetyl Hexapeptide-8

Palmitoyl Hexapeptide-12

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-5

Tocopherol

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Citric Acid

Coco-Caprylate/Caprate

Xanthan Gum

Caprylhydroxamic Acid

Steareth-20

Chlorhexidine Digluconate

N-Hydroxysuccinimide

Chrysin

Cetyl Glyceryl Ether

Sodium Benzoate

Potassium Sorbate

Biotin

Caprylyl Glycol

Sodium Citrate

Citronellol

Geraniol

Water, Glycerin, Propanediol, Dicaprylyl Carbonate, Squalane, Coconut Alkanes, Cetearyl Olivate, Rosa Damascena Flower Water, Sorbitan Olivate, Niacinamide, Acetyl Hexapeptide-8, Palmitoyl Hexapeptide-12, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Tocopherol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Citric Acid, Coco-Caprylate/Caprate, Xanthan Gum, Caprylhydroxamic Acid, Steareth-20, Chlorhexidine Digluconate, N-Hydroxysuccinimide, Chrysin, Cetyl Glyceryl Ether, Sodium Benzoate, Potassium Sorbate, Biotin, Caprylyl Glycol, Sodium Citrate, Citronellol, Geraniol

Heptyl Glucoside

Isodecyl Neopentanoate

Acacia Senegal Gum

Polysorbate 20

Centella Asiatica Leaf Extract

Helianthus Annuus Seed Oil

Phospholipids

Glycolipids

Dimethyl Sulfone

Ornithine

Lecithin

Hydrogenated Lecithin

Copper Lysinate/Prolinate

Methylglucoside Phosphate

Crocus Chrysanthus Bulb Extract

Sh-Oligopeptide-1

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Pentapeptide-18

Pentapeptide-48

Butyrospermum Parkii Butter

Leuconostoc/Radish Root Ferment Filtrate

Caprylic/Capric Triglyceride

Ethylhexylglycerin

C12-15 Alkyl Benzoate

Sclerotium Gum

Levulinic Acid

P-Anisic Acid

Sodium Gluconate

Maltodextrin

Sodium Hydroxide

Heptanol

Phenethyl Alcohol

Phenoxyethanol

Water, Glycerin, Heptyl Glucoside, Isodecyl Neopentanoate, Acacia Senegal Gum, Polysorbate 20, Centella Asiatica Leaf Extract, Helianthus Annuus Seed Oil, Tocopherol, Phospholipids, Glycolipids, Dimethyl Sulfone, Ornithine, Lecithin, Hydrogenated Lecithin, Copper Lysinate/Prolinate, Methylglucoside Phosphate, Crocus Chrysanthus Bulb Extract, Sh-Oligopeptide-1, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Pentapeptide-18, Pentapeptide-48, Butyrospermum Parkii Butter, Leuconostoc/Radish Root Ferment Filtrate, Caprylic/Capric Triglyceride, Ethylhexylglycerin, C12-15 Alkyl Benzoate, Sclerotium Gum, Xanthan Gum, Caprylyl Glycol, Levulinic Acid, P-Anisic Acid, Sodium Gluconate, Propanediol, Maltodextrin, Citric Acid, Sodium Hydroxide, Heptanol, Phenethyl Alcohol, Phenoxyethanol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Side-by-side

  1. 01Water
  2. 02Glycerin
  3. 03Heptyl Glucoside
  4. 04Isodecyl Neopentanoate
  5. 05Acacia Senegal Gum
  6. 06Polysorbate 20
  7. 07Centella Asiatica Leaf Extract
  8. 08Helianthus Annuus Seed Oil
  9. 09Tocopherol
  10. 10Phospholipids
  11. 11Glycolipids
  12. 12Dimethyl Sulfone
  13. 13Ornithine
  14. 14Lecithin
  15. 15Hydrogenated Lecithin
  16. 16Copper Lysinate/Prolinate
  17. 17Methylglucoside Phosphate
  18. 18Crocus Chrysanthus Bulb Extract
  19. 19Sh-Oligopeptide-1
  20. 20Dipeptide Diaminobutyroyl Benzylamide Diacetate
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side

04

Ask the journal

Related questions

01What if I have acne-prone skin?

The formulations are generally non-comedogenic but individual responses vary. Peptides themselves do not cause acne and may help improve scarring and inflammation. Start with one product at a time to identify any that trigger breakouts for your specific skin.

Source · seekpeptides.com