Neogen Sur.Medic Super Ceramide 100 Renewal Cream Versus Dermatica Nourishing Ceramide + Peptide Moisturizer

Neogen Sur.Medic Super Ceramide 100 Renewal Cream Versus Dermatica Nourishing Ceramide + Peptide Moisturizer

This barrier-repair moisturizer is formulated around Niacinamide and Ceramide NP to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Niacinamide and Ceramide NP to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dipropylene Glycol

Propanediol

1,2-Hexanediol

Niacinamide

Neopentyl Glycol Diheptanoate

Methyl Trimethicone

Cetyl Alcohol

Stearyl Alcohol

Coco-Caprylate/Caprate

Diisostearyl Malate

Phenyl Trimethicone

Palmitic Acid

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Stearic Acid

Glycereth-25 PCA Isostearate

Glyceryl Stearate

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Butylene Glycol

Coptis Japonica Extract

Xanthan Gum

Ceramide NP

Ethylhexylglycerin

Adenosine

Citrus Aurantium Bergamia Fruit Oil

Lavandula Angustifolia Oil

Centella Asiatica Extract

Bifida Ferment Lysate

Citrus Aurantium Dulcis Peel Oil

Aniba Rosaeodora Wood Oil

Rosmarinus Officinalis Leaf Oil

Eucalyptus Globulus Leaf Oil

Sodium Hyaluronate

Caprylic/Capric Triglyceride

Adansonia Digitata Seed Oil

Hydrogenated Lecithin

Hyaluronic Acid

Tocopheryl Acetate

Tocopherol

Squalane

Artemisia Vulgaris Extract

Allantoin

Cocos Nucifera Oil

Panthenol

Hydrolyzed Collagen

Ceramide Ns

Ceramide As

Mannitol

Bentonite

Ceramide EOP

Ceramide AP

Xylitylglucoside

Anhydroxylitol

Hydrolyzed Hyaluronic Acid

Xylitol

Olive Oil Decyl Esters

Camellia Sinensis Leaf Extract

Anthemis Nobilis Flower Oil

Citrus Aurantifolia Fruit Extract

Adansonia Digitata Leaf Extract

Citric Acid

Hydrated Silica

Glucose

Pelargonium Graveolens Flower Oil

Pseudoalteromonas Ferment Extract

Mentha Viridis Leaf Oil

Caprylyl Glycol

Lactic Acid

Rose Flower Oil

Calendula Officinalis Extract

Chamomilla Recutita Extract

Propolis Extract

Squalene

Palmitoyl Tripeptide-5

Chlorella Minutissima Extract

Acetyl Tetrapeptide-11

Phellinus Linteus Extract

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Melissa Officinalis Leaf Extract

Serine

Alanine

Proline

Sodium Phosphate

Sea Salt

Acetyl Hexapeptide-8

Beta-Glucan

Sodium Hydroxide

Melaleuca Alternifolia Leaf Extract

Oligopeptide-1

Disodium EDTA

Water, Glycerin, Dipropylene Glycol, Propanediol, 1,2-Hexanediol, Niacinamide, Neopentyl Glycol Diheptanoate, Methyl Trimethicone, Cetyl Alcohol, Stearyl Alcohol, Coco-Caprylate/Caprate, Diisostearyl Malate, Phenyl Trimethicone, Palmitic Acid, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Stearic Acid, Glycereth-25 PCA Isostearate, Glyceryl Stearate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Butylene Glycol, Coptis Japonica Extract, Xanthan Gum, Ceramide NP, Ethylhexylglycerin, Adenosine, Citrus Aurantium Bergamia Fruit Oil, Lavandula Angustifolia Oil, Centella Asiatica Extract, Bifida Ferment Lysate, Citrus Aurantium Dulcis Peel Oil, Aniba Rosaeodora Wood Oil, Rosmarinus Officinalis Leaf Oil, Eucalyptus Globulus Leaf Oil, Sodium Hyaluronate, Caprylic/Capric Triglyceride, Adansonia Digitata Seed Oil, Hydrogenated Lecithin, Hyaluronic Acid, Tocopheryl Acetate, Tocopherol, Squalane, Artemisia Vulgaris Extract, Allantoin, Cocos Nucifera Oil, Panthenol, Hydrolyzed Collagen, Ceramide Ns, Ceramide As, Mannitol, Bentonite, Ceramide EOP, Ceramide AP, Xylitylglucoside, Anhydroxylitol, Hydrolyzed Hyaluronic Acid, Xylitol, Olive Oil Decyl Esters, Camellia Sinensis Leaf Extract, Anthemis Nobilis Flower Oil, Citrus Aurantifolia Fruit Extract, Adansonia Digitata Leaf Extract, Citric Acid, Hydrated Silica, Glucose, Pelargonium Graveolens Flower Oil, Pseudoalteromonas Ferment Extract, Mentha Viridis Leaf Oil, Caprylyl Glycol, Lactic Acid, Rose Flower Oil, Calendula Officinalis Extract, Chamomilla Recutita Extract, Propolis Extract, Squalene, Palmitoyl Tripeptide-5, Chlorella Minutissima Extract, Acetyl Tetrapeptide-11, Phellinus Linteus Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Melissa Officinalis Leaf Extract, Serine, Alanine, Proline, Sodium Phosphate, Sea Salt, Acetyl Hexapeptide-8, Beta-Glucan, Sodium Hydroxide, Melaleuca Alternifolia Leaf Extract, Oligopeptide-1, Disodium EDTA

Cetearyl Alcohol

Butyrospermum Parkii Butter

C12-15 Alkyl Benzoate

Vitis Vinifera Oil

Dimethicone

Sorbitan Stearate

Phenoxyethanol

Polyacrylate Crosspolymer-6

Sodium Lauroyl Lactylate

Trisodium Ethylenediamine Disuccinate

Carbomer

Phytosphingosine

Cholesterol

Polysorbate 20

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Water, Cetearyl Alcohol, Glycerin, Butyrospermum Parkii Butter, C12-15 Alkyl Benzoate, Niacinamide, Vitis Vinifera Oil, Dimethicone, Panthenol, Sorbitan Stearate, Squalane, Tocopheryl Acetate, Phenoxyethanol, Butylene Glycol, Polyacrylate Crosspolymer-6, Sodium Lauroyl Lactylate, Centella Asiatica Extract, Ethylhexylglycerin, Sodium Hyaluronate, Trisodium Ethylenediamine Disuccinate, Citric Acid, Carbomer, Ceramide NP, Ceramide AP, Phytosphingosine, Cholesterol, Polysorbate 20, Xanthan Gum, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Centella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier.

That research keeps pointing back to the same four triterpenoid saponins: Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid.

These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.

Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.

Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.

Here is the short version of what they do in the skin:

So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.

Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:

Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.

Centella is one of the most easygoing actives out there.

It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.

On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.

Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.

But as with any new active, a patch test is still a smart move for very reactive skin.

Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).

The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning).

In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently.

Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event.

Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.

Ceramide AP is is a skin-identical lipid that mimics what your skin already makes naturally. Ceramides help maintain epidermal integrity and barrier function.

You'll often see this ingredient paired with other ceramides (like ceramide NP), cholesterol, or fatty acids because this combination best mimics the natural lipid mix your skin already has.

The skin's ability to produce ceramides gets disrupted in skin conditions like eczema. This in turn weakens the skin barrier and applying ceramides topically has been shown to replenish what's been lost to restore barrier function.

Most of the studies with Ceramide AP test it as part of a multi-ceramide complex; studies reinforce ceramide AP's role in rebalancing ceramides in skin and improving skin hydration.

Ceramide EOP is formally known as Ceramide 1.

It is naturally found in skin and part of the intercellular "mortar" holding everything together in your outermost layer.

EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.

What makes Ceramide EOP special is its ultra-long fatty acid chain; this unique structure allows it to bridge the lipid layers in your skin barrier to prevent water loss (something no other ceramide can do).

Low levels of Ceramide EOP have been found in people with eczema and psoriasis.

Using it together with other ceramides, cholesterol, and linoleic acid have been shown to meaningfully improve hydration and reduce water loss.

In one clinical study, a regimen using Ceramide EOP, NP, and AP led to significant symptom improvements in patients with eczema, psoriasis, and dry skin in just 4 weeks.

You'll usually see concentrations between 0.1-0.5% in formulations. Overall, this is a well-tolerated and safe ingredient for cosmetic use.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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