Skin science article
Numbuzin No.6 Deep Sleep Mask Serum Versus Peach & Lily Copper Peptide Pro Firming Serum
Numbuzin No.6 Deep Sleep Mask Serum Versus Peach & Lily Copper Peptide Pro Firming Serum This hydrating serum is formulated around Niacinamide and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier. This anti-aging serum is formulated around Co
Numbuzin No.6 Deep Sleep Mask Serum Versus Peach & Lily Copper Peptide Pro Firming Serum
This hydrating serum is formulated around Niacinamide and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier.
This anti-aging serum is formulated around Copper Tripeptide-1 and Acetyl Hexapeptide-8 to soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water 63%
Butylene Glycol
Propanediol
Glycerin
Niacinamide
1,2-Hexanediol
Chlorella Vulgaris Extract
Xylitylglucoside
Sodium Hyaluronate
Hydrolyzed Hyaluronic Acid
Xylitol
Melia Azadirachta Leaf Extract
Melia Azadirachta Flower Extract
Coccinia Indica Fruit Extract
Aloe Barbadensis Flower Extract
Solanum Melongena Fruit Extract
Ocimum Sanctum Leaf Extract
Corallina Officinalis Extract
Curcuma Longa Root Extract
Hyaluronic Acid
Glycereth-26
Panthenol
Pentylene Glycol
Glucose
Sodium PCA
Anhydroxylitol
Fructooligosaccharides
Fructose
Polyglyceryl-10 Laurate
Sodium Citrate
Dipotassium Glycyrrhizate
Sodium Hyaluronate Crosspolymer
Ethylhexylglycerin
Adenosine
Hydrolyzed Glycosaminoglycans
Citric Acid
Benzyl Glycol
Tocopherol
Xanthan Gum
Water 63%, Butylene Glycol, Propanediol, Glycerin, Niacinamide, 1,2-Hexanediol, Chlorella Vulgaris Extract, Xylitylglucoside, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Xylitol, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Aloe Barbadensis Flower Extract, Solanum Melongena Fruit Extract, Ocimum Sanctum Leaf Extract, Corallina Officinalis Extract, Curcuma Longa Root Extract, Hyaluronic Acid, Glycereth-26, Panthenol, Pentylene Glycol, Glucose, Sodium PCA, Anhydroxylitol, Fructooligosaccharides, Fructose, Polyglyceryl-10 Laurate, Sodium Citrate, Dipotassium Glycyrrhizate, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Adenosine, Hydrolyzed Glycosaminoglycans, Citric Acid, Benzyl Glycol, Tocopherol, Xanthan Gum
Water
Dipropylene Glycol
Betaine
Copper Tripeptide-1
Acetyl Hexapeptide-8
Palmitoyl Tripeptide-1
Tetrapeptide-21
Tetrapeptide-30
Heptasodium Hexacarboxymethyl Dipeptide-12
Acetyl Tetrapeptide-5
Palmitoyl Tripeptide-38
Palmitoyl Pentapeptide-4
Dipeptide-2
Tripeptide-1
Hexapeptide-9
Nonapeptide-1
Collagen Extract
Serine
Methionine
Cysteine
Arginine
Acmella Oleracea Extract
Alpha-Glucan Oligosaccharide
Ulmus Davidiana Root Extract
Cichorium Intybus Root Extract
Helianthus Tuberosus Root Extract
Tremella Fuciformis Extract
Fomes Officinalis Extract
Lentinus Edodes Extract
Pyrus Malus Fruit Extract
Lens Esculenta Fruit Extract
Citrullus Lanatus Fruit Extract
Sodium Acetylated Hyaluronate
Potassium Hyaluronate
Squalane
Ficus Carica Fruit Extract
Cynanchum Atratum Extract
Hydroxypropyltrimonium Hyaluronate
Gellan Gum
Polyglyceryl-10 Eicosanedioate/Tetradecanedioate
Polyquaternium-51
Sodium Polyacryloyldimethyl Taurate
Hydroxypropyl Cyclodextrin
Hydroxyethylcellulose
Caprylyl Glycol
Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Betaine, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Tetrapeptide-21, Tetrapeptide-30, Heptasodium Hexacarboxymethyl Dipeptide-12, Acetyl Tetrapeptide-5, Palmitoyl Tripeptide-38, Palmitoyl Pentapeptide-4, Dipeptide-2, Tripeptide-1, Hexapeptide-9, Nonapeptide-1, Collagen Extract, Serine, Methionine, Cysteine, Arginine, Acmella Oleracea Extract, Alpha-Glucan Oligosaccharide, Sodium PCA, Ulmus Davidiana Root Extract, Cichorium Intybus Root Extract, Helianthus Tuberosus Root Extract, Tremella Fuciformis Extract, Fomes Officinalis Extract, Lentinus Edodes Extract, Pyrus Malus Fruit Extract, Lens Esculenta Fruit Extract, Citrullus Lanatus Fruit Extract, Sodium Acetylated Hyaluronate, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Potassium Hyaluronate, Squalane, Ficus Carica Fruit Extract, Cynanchum Atratum Extract, Hydroxypropyltrimonium Hyaluronate, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Curcuma Longa Root Extract, Corallina Officinalis Extract, Solanum Melongena Fruit Extract, Coccinia Indica Fruit Extract, Gellan Gum, Butylene Glycol, Adenosine, Aloe Barbadensis Flower Extract, Melia Azadirachta Flower Extract, Polyglyceryl-10 Eicosanedioate/Tetradecanedioate, Polyquaternium-51, Sodium Polyacryloyldimethyl Taurate, Hydroxypropyl Cyclodextrin, Ethylhexylglycerin, Hydroxyethylcellulose, Caprylyl Glycol
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Aloe Barbadensis Flower Extract is the extract from the flowers of the aloe vera plant. In cosmetics, it functions as a skin conditioning agent.
Here's the honest part: most of the famous "aloe" research is on the leaf and this flower extract is much less studied. It shouldn't be assumed to do everything the gel is known for.
However, there is a small body of flower-specific research that is interesting to take a look at.
The flowers of Aloe vera contain volatile compounds and ascorbic acid. And when researchers looked closer, they found the flower is rich in antioxidants called phenolics that lined up with the extract's strong antioxidant activity.
This extract also showed some ability to fight off a common bacteria (Pseudomonas aeruginosa) in lab tests.
In lab and mouse studies, those phenolic compounds behaved like solid antioxidants though human skin trials on the flower extract are still needed.
Safety-wise, this ingredient is pretty assuring. The CIR Expert Panel deems this ingredient safe in current practices of use and only rare cases of acute eczema, contact urticaria, and dermatitis have been reported.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Coccinia Indica Fruit Extract is also known as Ivy Gourd Fruit Extract. It has skin conditioning properties.
The fruit is rich in flavonoids, phenolic acids, terpenoids, and sterols that show antioxidant and anti-inflammatory effect in vitro. This is because the fruit contains a thick mucilage that forms a protective and soothing layer on the skin's surface.
The extract itself has demonstrated antioxidant, soothing, and potential anti-allergy properties.
Most of this research is done in vitro and dedicated clinical studies on topical application are still limited.
Corallina Officinalis Extract is from the red seaweed, Corallina Officinalis. This seaweed is found all over the world but is most common in the rocky shores of Great Britain and Ireland.
Corallina Officinalis Extract contains antioxidant and emollient properties.
Extracted polysaccharides, galactose and xylose, in red algae showed antioxidant activity. Antioxidants help with anti-aging by neutralizing free-radical molecules. Free-radical molecules may damage your skin cells and DNA. Galactose is also a PHA.
Corallina Officinalis is structurally similar to coral due to its high calcium content.
Curcuma Longa Root Extract comes from the rhizome (underground stem) of the turmeric plant.
While the official EU Cosing Database lists this ingredient as a fragrance, it actually does more than give products a scent.
This ingredient contains a group of yellow pigments called curcuminoids (mostly curcumin) that give it genuine antioxidant and anti-inflammatory activity in skin.
Reviews of topical clinical studies have found turmeric/curcumin to be generally well-tolerated and useful across conditions like eczema and mild inflammation.
One thing working in its favor is that curcumin barely penetrates; in lab skin-permeation testing, the curcuminoids mostly stayed in the outermost layer of skin. This is a good thing because its soothing and antioxidant activity is a surface-level job anyway.
At this time, industry data shows there's no single "correct" cosmetic percentage. It's used across a wide range depending on the product and varies from tiny fractions of a percent up to a few percent.
Allergy-wise, curcumin is a documented (but uncommon) contact allergen. It can also cross react with related plants, so anyone with a turmeric/ginger/cinnamon allergy or reactive skin should patch test first.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.
Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.
The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
This is why the best HA serums blend the two sizes together so you get the best of both worlds.
The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.
A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.
These are some other common types of Hyaluronic Acid:
Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.
It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.
Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.
Most formulations will combine all sizes to get the best of both worlds.
Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.
Melia Azadirachta Flower Extract is from the Neem tree. Neem trees originate from India.
Melia Azadirachta Flower Extract contains antioxidants. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.
The flowers of this tree are lilac colored.
This ingredient is also known as neem leaf extract. It contains natural compounds like nimbidin, quercetin, and other polyphenols that give it antibacterial, antifungal, and anti-inflammatory activity.
Lab studies have shown neem leaf extract can inhibit acne-related bacteria and help calm skin. Animal studies on wound gels using 1-3% neem leaf extract found it sped up healing without causing irritation.
A wound-healing study testing gels with the extract at 1%, 2%, and 3% concentrations and found none of them irritated the skin.
Most commercial products also use it in a similar low range (typically under 5%).
Allergy-wise, there are some case reports on neem oil causing allergic contact dermatitis so people with plant/botanical sensitivities may want to patch test first.
Ocimum Sanctum Leaf Extract comes from the Holy Basil plant. Holy Basil is native to India.
Holy Basil is rich in antioxidants due to its high romarinic acid, ferulic acid, and rutin content. This gives it skin brightening and soothing properties.
While Holy Basil has many claims to help fight acne, more research is needed.
One thing to note is the presence of tannins; tannins are naturally found in nature. However, this compound may be skin-sensitizing.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.
A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.
A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.
More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.
Sodium PCA (the salt of PCA) is one of the most well-established humectants in skincare.
Why is it so special? Your skin already makes it naturally; it's a natural component of your skin's Natural Moisturizing Factor (NMF), or the mix of water-binding compounds inside your skin cells that keeps things soft and hydrated.
As a cosmetic ingredient, it grabs water and holds it in the upper layers of skin to smooth roughness and ease dehydration.
There's some clinical support for the NMF approach with a study showing that a cream built to mimic the skin's NMF significantly boosted hydration.
Safety-wise, this ingredient non-irritating, non-comedogenic, and non-phototoxic in testing, with minimal skin absorption.
It also works really well with other hydrators like glycerin or hyaluronic acid, and typical usage is somewhere between 0.2-4%.
This ingredient comes from eggplant (or aubergine). It has skin conditioning properties due to its abundance of antioxidants like Chlorogenic Acid, Caffeic Acid, and Nasunin.
Nasunin is the pigment concentrated in the purple peel and has demonstrated the abilityu to neutralize free radicals and bind excess iron in lab studies.
Lab studies have shown that eggplant extracts can lower oxidative stress and protect skin cell membranes from damage. A 2025 study found that specific compounds in eggplant (particularly a phenolamide called N-Trans-Feruloylputrescine) may support skin health by neutralizing 2-nonenal, a byproduct linked to aging skin.
Overall, this is a gentle, well-tolerated ingredient that adds a little extra antioxidant support to your routine.
Those with nighshade vegetable allergies (tomatoes, peppers, potatoes) should patch test as eggplant is part of the same family.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!