Skin science article
Olehenriksen Pout Preserve Peptide Lip Treatment Versus Persona Daymask Peptide Lip Balm
Olehenriksen Pout Preserve Peptide Lip Treatment Versus Persona Daymask Peptide Lip Balm This anti-aging lip moisturizer is formulated around Palmitoyl Hexapeptide-12 and Palmitoyl Tripeptide-1 to soften the look of wrinkles. This anti-aging lip moisturizer is
Olehenriksen Pout Preserve Peptide Lip Treatment Versus Persona Daymask Peptide Lip Balm
This anti-aging lip moisturizer is formulated around Palmitoyl Hexapeptide-12 and Palmitoyl Tripeptide-1 to soften the look of wrinkles.
This anti-aging lip moisturizer is formulated around Avena Sativa Kernel Oil and Squalane to soften the look of wrinkles and hydrate lips.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Polybutene
Hydrogenated Polydecene
Bis-Diglyceryl Polyacyladipate-2
Hydrogenated Styrene/Isoprene Copolymer
Cera Microcristallina
Silica
Rubus Chamaemorus Seed Oil
Garcinia Indica Seed Butter
Euterpe Oleracea Sterols
Palmitoyl Hexapeptide-12
Palmitoyl Tripeptide-1
Tocopheryl Acetate
Tocopherol
Irvingia Gabonensis Kernel Butter
Citrus Aurantium Dulcis Peel Wax
Linoleic Acid
Linolenic Acid
Oleic Acid
Lactic Acid
Helianthus Annuus Seed Oil
Caprylic/Capric Triglyceride
Copernicia Cerifera Cera
Hydrogenated Coco-Glycerides
Sorbitan Isostearate
Pentaerythrityl Tetraisostearate
Mica
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
Octyldodecanol
Ethylhexyl Palmitate
Dicalcium Phosphate
Tribehenin
Propylene Carbonate
Stearalkonium Hectorite
Tin Oxide
Sodium Saccharin
Parfum
CI 77491
CI 77492
CI 77499
CI 77891
Polybutene, Hydrogenated Polydecene, Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Styrene/Isoprene Copolymer, Cera Microcristallina, Silica, Rubus Chamaemorus Seed Oil, Garcinia Indica Seed Butter, Euterpe Oleracea Sterols, Palmitoyl Hexapeptide-12, Palmitoyl Tripeptide-1, Tocopheryl Acetate, Tocopherol, Irvingia Gabonensis Kernel Butter, Citrus Aurantium Dulcis Peel Wax, Linoleic Acid, Linolenic Acid, Oleic Acid, Lactic Acid, Helianthus Annuus Seed Oil, Caprylic/Capric Triglyceride, Copernicia Cerifera Cera, Hydrogenated Coco-Glycerides, Sorbitan Isostearate, Pentaerythrityl Tetraisostearate, Mica, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Octyldodecanol, Ethylhexyl Palmitate, Dicalcium Phosphate, Tribehenin, Propylene Carbonate, Stearalkonium Hectorite, Tin Oxide, Sodium Saccharin, Parfum, CI 77491, CI 77492, CI 77499, CI 77891
Polyisobutene
Bis-Behenyl/Isostearyl/Phytosteryl Dimer Dilinoleyl Dimer Dilinoleate
Diisostearyl Malate
C18-38 Alkyl Hydroxystearoyl Stearate
Avena Sativa Kernel Oil
Jojoba Esters
Limnanthes Alba Seed Oil
Trihydroxystearin
Squalane
Phenoxyethanol
Calcium Sodium Borosilicate
Silica Dimethyl Silylate
Ethylhexylglycerin
Alaria Esculenta Extract
CI 15850
CI 45410
Polyisobutene, Bis-Diglyceryl Polyacyladipate-2, Bis-Behenyl/Isostearyl/Phytosteryl Dimer Dilinoleyl Dimer Dilinoleate, Diisostearyl Malate, Caprylic/Capric Triglyceride, C18-38 Alkyl Hydroxystearoyl Stearate, Avena Sativa Kernel Oil, Jojoba Esters, Limnanthes Alba Seed Oil, Trihydroxystearin, Squalane, Phenoxyethanol, Calcium Sodium Borosilicate, Silica Dimethyl Silylate, Tocopheryl Acetate, Ethylhexylglycerin, Octyldodecanol, Ethylhexyl Palmitate, Tribehenin, Tocopherol, Alaria Esculenta Extract, Tin Oxide, Sorbitan Isostearate, Lactic Acid, Palmitoyl Tripeptide-1, CI 77891, CI 77492, CI 15850, CI 45410
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Bis-Diglyceryl Polyacyladipate-2 is a synthetic emollient that works as a lanolin substitute.
This ingredient is a great vegan option for those avoiding animal-derived ingredients.
It mostly stays on the surface of skin where it helps hydrate due to its large molecular size and low water solubility.
Due to it being derived from fatty acids, this ingredient may not be Malassezia or fungal acne safe.
Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
CI 77492 is also hydrated iron III oxide. It's sole purpose is to give a yellow hue to products.
Iron III oxides are classified as inorganic chemicals for coloring.
Synthetically created CI 77492 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.
Ci 77891 is a white pigment from Titanium dioxide. It is naturally found in minerals such as rutile and ilmenite.
It's main function is to add a white color to cosmetics. It can also be mixed with other colors to create different shades.
Ci 77891 is commonly found in sunscreens due to its ability to block UV rays.
Ethylhexyl Palmitate, also known as octyl palmitate, is created from 2-ethylhexyl alcohol and palmitic acid.
In cosmetics, it plays many roles:
One thing worth noting: a controlled study found this ingredient applied under occlusion to acne-prone subjects increased microcomedones. Just keep in mind this was under occlusive conditions and don't reflect how most products are used day-to-day.
For most people, this is a well-tolerated and lightweight ingredient.
This ingredient may not be fungal acne safe because it is an ester of palmitic acid, a C16 fatty acid that falls within the C11-24 range that Malassezia can metabolize.
Lactic Acid is another well-loved alpha hydroxy acid (AHA). It is gentler than glycolic acid but still highly effective.
Its main role is to exfoliate the surface of the skin by loosening the “glue” that holds dead skin cells together. Shedding those old cells leads to smoother, softer, and more even-toned skin.
Because lactic acid molecules are larger than glycolic acid, they don’t penetrate as deeply. This means they’re less likely to sting or irritate, making it a great choice for beginners or those with sensitive skin.
Like glycolic acid, it can:
Lactic acid also acts as a humectant (like hyaluronic acid). It can draw water into the skin to improve hydration and also plays a role in the skin's natural moisturizing factor (NMF) in the form of sodium lactate.
Studies show it can boost ceramide production to strengthen the skin barrier and even help balance the skin’s microbiome.
To get results, choose products with a pH between 3-4.
Lower strengths (5-12%) focus on surface exfoliation; higher strengths (12% and up) can reach deeper in the dermis (deeper, supportive layer) to improve skin texture and firmness over time.
Though it was originally derived from milk, most modern lactic acid used in skincare is vegan. It is made through non-dairy fermentation to create a bio-identical and stable form suitable for all formulations.
When lactic acid shows up near the end of an ingredient list, it usually means the brand added just a tiny amount to adjust the product’s pH.
Legend has it that Cleopatra used to bathe in sour milk to help reduce wrinkles.
Lactic acid is truly a gentle multitasker: it exfoliates, hydrates, strengthens, and brightens. It's a great ingredient for giving your skin a smooth, glowing, and healthy look without the harshness of stronger acids.
Read more about some other popular AHA's here:
Octyldodecanol is a fatty alcohol sourced from plant oils like coconut or palm (or made synthetically).
It is:
You'll likely see this in many BHA products because this is the go-to solvent for salicylic acid.
This ingredient is typically used at levels between 2-20%.
Regarding fungal acne: In 2019, this ingredient was tested against multiple Malassezia species (the yeast that causes fungal acne) and showed no growth.
Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid.
That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference.
Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.
In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing.
Human clinical data is promising, but modest:
A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm.
A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks.
You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex.
Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.
Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.
As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.
In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.
Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.
Tin Oxide is an inorganic oxide used to add opacity and volume to a product. In nature, it is already found in mineral form. The main ore of tin is an opaque and shiny mineral called casseterite.
Tin Oxide helps remove translucency in a product, or make it more opaque. Besides adding opacity, tin oxide is used for bulking to add volume.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.
Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.
It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.
One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.
Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.
Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.
The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.
Most leave-on skincare keeps it at the lower end, often between 0.5-1%.
Tribehenin is the triglyceride of glycerin and behenic acid. It is an emollient that helps soften and condition skin.
Safety-wise, this is a well-vetted ingredient. Repeated-insult patch tests of 0.38% tribehenin did not trigger sensitization.
This ingredient may not be fungal acne safe because behenic acid falls into the chain-length range that Malassezia yeasts can feed on.