Skin science article
One Thing Peptide Retinal Cream Versus Celimax Pore + Dark Spot Brightening Cream
One Thing Peptide Retinal Cream Versus Celimax Pore + Dark Spot Brightening Cream This anti-aging moisturizer is formulated around Niacinamide and Retinal to soften the look of wrinkles and refine skin texture. This brightening moisturizer is formulated around
One Thing Peptide Retinal Cream Versus Celimax Pore + Dark Spot Brightening Cream
This anti-aging moisturizer is formulated around Niacinamide and Retinal to soften the look of wrinkles and refine skin texture.
This brightening moisturizer is formulated around Niacinamide and Tranexamic Acid to fade the look of dark spots and refine the look of pores.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Hydrogenated Polydecene
Glycerin
Dipropylene Glycol
Cetearyl Alcohol
Propanediol
Caprylic/Capric Triglyceride
1,2-Hexanediol
Butyrospermum Parkii Butter
Niacinamide
Vinyldimethicone
Hydrogenated Polyisobutene
Palmitic Acid
Limnanthes Alba Seed Oil
Stearic Acid
Butylene Glycol
Synthetic Beeswax
Polyglyceryl-2 Stearate
Cetearyl Glucoside
Glyceryl Stearate
Polyacrylate-13
Stearyl Alcohol
Carbomer
Tromethamine
Ethylhexylglycerin
Xanthan Gum
Dextrin
Gardenia Florida Fruit Extract
Adenosine
Polyglyceryl-10 Laurate
Ethylhexyl Palmitate
Disodium EDTA
Sorbitan Isostearate
Macadamia Ternifolia Seed Oil
Phosphatidylcholine
Hyaluronic Acid
Hydrolyzed Hyaluronic Acid
Sodium Hyaluronate
Cholesterol
Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate
Aluminum/Magnesium Hydroxide Stearate
Brassica Campestris Sterols
Hydrogenated Lecithin
Polyglyceryl-10 Oleate
Retinal
Sodium Lactate
Palmitoyl Tripeptide-5
Polysorbate 20
Potassium Cetyl Phosphate
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
Caprylyl Glycol
Sodium Ascorbyl Phosphate
Palmitoyl Tripeptide-1
Acetyl Hexapeptide-8
Palmitoyl Tetrapeptide-7
Copper Tripeptide-1
Palmitoyl Pentapeptide-4
Water, Hydrogenated Polydecene, Glycerin, Dipropylene Glycol, Cetearyl Alcohol, Propanediol, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Butyrospermum Parkii Butter, Niacinamide, Vinyldimethicone, Hydrogenated Polyisobutene, Palmitic Acid, Limnanthes Alba Seed Oil, Stearic Acid, Butylene Glycol, Synthetic Beeswax, Polyglyceryl-2 Stearate, Cetearyl Glucoside, Glyceryl Stearate, Polyacrylate-13, Stearyl Alcohol, Carbomer, Tromethamine, Ethylhexylglycerin, Xanthan Gum, Dextrin, Gardenia Florida Fruit Extract, Adenosine, Polyglyceryl-10 Laurate, Ethylhexyl Palmitate, Disodium EDTA, Sorbitan Isostearate, Macadamia Ternifolia Seed Oil, Phosphatidylcholine, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Cholesterol, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Aluminum/Magnesium Hydroxide Stearate, Brassica Campestris Sterols, Hydrogenated Lecithin, Polyglyceryl-10 Oleate, Retinal, Sodium Lactate, Palmitoyl Tripeptide-5, Polysorbate 20, Potassium Cetyl Phosphate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Caprylyl Glycol, Sodium Ascorbyl Phosphate, Palmitoyl Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Tetrapeptide-7, Copper Tripeptide-1, Palmitoyl Pentapeptide-4
Tranexamic Acid
Hydrogenated Poly(C6-14 Olefin)
Phenyl Trimethicone
Macadamia Integrifolia Seed Oil
Dicaprylyl Ether
Cetearyl Olivate
Glyceryl Stearate Se
Sorbitan Olivate
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Behenyl Alcohol
Dimethiconol
Laminaria Japonica Extract
Eclipta Prostrata Leaf Extract
Ceramide NP
Betaine
Fructooligosaccharides
Eriobotrya Japonica Leaf Extract
Coptis Japonica Root Extract
Beta-Glucan
Mentha Viridis Extract
Theobroma Cacao Seed Extract
Tocopherol
Ascorbic Acid Polypeptide
Ceramide As
Ceramide AP
Ceramide Ns
Ceramide EOP
Water, Glycerin, Niacinamide, Tranexamic Acid, Caprylic/Capric Triglyceride, Dipropylene Glycol, 1,2-Hexanediol, Hydrogenated Poly(C6-14 Olefin), Phenyl Trimethicone, Macadamia Integrifolia Seed Oil, Dicaprylyl Ether, Vinyldimethicone, Cetearyl Alcohol, Propanediol, Cetearyl Olivate, Glyceryl Stearate Se, Sorbitan Olivate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Behenyl Alcohol, Dimethiconol, Cetearyl Glucoside, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Hydrogenated Lecithin, Ceramide NP, Betaine, Ethylhexylglycerin, Xanthan Gum, Fructooligosaccharides, Adenosine, Eriobotrya Japonica Leaf Extract, Coptis Japonica Root Extract, Cholesterol, Butylene Glycol, Beta-Glucan, Mentha Viridis Extract, Hydrolyzed Hyaluronic Acid, Theobroma Cacao Seed Extract, Dextrin, Tocopherol, Ascorbic Acid Polypeptide, Glyceryl Stearate, Ceramide As, Ceramide AP, Ceramide Ns, Ceramide EOP
Reviews
Be the first to review
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Cetearyl Glucoside is a sugar-based emulsifier. It is usually made by combining cetearyl alcohol and glucose.
Belonging to the aklyl polyglucoside (APG) family, Cetearyl Glucoside has a sugar "head" that loves water and a fatty "tail" that loves oil. This means it can shuffle oil and water into a stable and smooth emulsion.
Typical use levels are between 1-5% and this ingredient is considered to be non-irritating by the CIR Expert Panel Review.
Once applied, your skin's glucoside hydrolases breaks it down to the parent fatty alcohol and glucose. This is why this ingredient may not be fungal acne safe.
Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.
It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).
This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.
Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.
Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.
Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.
Dextrin is a starch-derived polysaccharide. It's made by partially breaking down corn, potato, or other plant starches.
Think of it as "half-processed" starch; it's less complex than the original but not fully broken down into sugar like maltodextrin.
In cosmetics, it mainly functions as a bulking agent, viscosity controller, binder, and absorbent. It helps thicken products, stabilize powders, and get certain textures a less "wet" feel.
This ingredient has a pretty solid safety profile; it's recognized as a safe food additive and its large molecular size means it doesn't meaningfully penetrate skin.
Human repeat insult patch tests using a rinse-off facial product containing 42.69% dextrin found no skin irritation or sensitization in 54 subjects.
Typical real-world usage is much lower: usually under 1% as a texture modifier and up to 40% in masks (rinse off products use less).
Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.
This ingredient helps:
Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.
As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.
Studies show Dipropylene Glycol is considered safe to use in skincare.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Hydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.
It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.
Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.
Most formulations will combine all sizes to get the best of both worlds.
Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Vinyldimethicone is a type of silicone.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.