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Skin science article

Paula's Choice 1% Retinol Treatment Versus Carrot & Stick The Repair Serum

Paula's Choice 1% Retinol Treatment Versus Carrot & Stick The Repair Serum This anti-aging treatment is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. This barrier-repair serum is formulated arou

Paula's Choice 1% Retinol Treatment Versus Carrot & Stick The Repair Serum

This anti-aging treatment is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture.

This barrier-repair serum is formulated around Niacinamide and Sh-Oligopeptide-1 to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Dimethicone

Glycerin

Butylene Glycol

Isononyl Isononanoate

Castor Isostearate Succinate

Glyceryl Stearate

C12-15 Alkyl Benzoate

Dimethicone Crosspolymer

PEG-33

Polysorbate 20

Behenyl Alcohol

PEG-100 Stearate

Pentaerythrityl Tetraisostearate

Polymethylsilsesquioxane

Tetrahexyldecyl Ascorbate

Retinol

Ceramide Ng

Palmitoyl Tetrapeptide-7

Palmitoyl Hexapeptide-12

Sodium Hyaluronate

Dipotassium Glycyrrhizate

Glycyrrhiza Glabra Root Extract

Avena Sativa Kernel Extract

Arctium Lappa Seed Oil

Salix Alba Extract

Glycine Soja Sterols

Lecithin

Allantoin

Tocopheryl Acetate

Hydrolyzed Soy Protein

Sorbitan Laurate

Acetyl Dipeptide-1 Cetyl Ester

Disodium EDTA

Hydroxyethylcellulose

Palmitoyl Tripeptide-1

Sodium Hydroxide

Tribehenin

Caprylyl Glycol

Ethylhexylglycerin

Pentylene Glycol

PEG-75 Shea Butter Glycerides

PPG-12/Smdi Copolymer

PEG-10 Phytosterol

PEG-8 Dimethicone

PEG-14

Magnesium Aluminum Silicate

Arachidyl Glucoside

Arachidyl Alcohol

Sclerotium Gum

Carbomer

Phenoxyethanol

Benzoic Acid

Water, Dimethicone, Glycerin, Butylene Glycol, Isononyl Isononanoate, Castor Isostearate Succinate, Glyceryl Stearate, C12-15 Alkyl Benzoate, Dimethicone Crosspolymer, PEG-33, Polysorbate 20, Behenyl Alcohol, PEG-100 Stearate, Pentaerythrityl Tetraisostearate, Polymethylsilsesquioxane, Tetrahexyldecyl Ascorbate, Retinol, Ceramide Ng, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra Root Extract, Avena Sativa Kernel Extract, Arctium Lappa Seed Oil, Salix Alba Extract, Glycine Soja Sterols, Lecithin, Allantoin, Tocopheryl Acetate, Hydrolyzed Soy Protein, Sorbitan Laurate, Acetyl Dipeptide-1 Cetyl Ester, Disodium EDTA, Hydroxyethylcellulose, Palmitoyl Tripeptide-1, Sodium Hydroxide, Tribehenin, Caprylyl Glycol, Ethylhexylglycerin, Pentylene Glycol, PEG-75 Shea Butter Glycerides, PPG-12/Smdi Copolymer, PEG-10 Phytosterol, PEG-8 Dimethicone, PEG-14, Magnesium Aluminum Silicate, Arachidyl Glucoside, Arachidyl Alcohol, Sclerotium Gum, Carbomer, Phenoxyethanol, Benzoic Acid

Niacinamide

Acacia Senegal Gum

Hydrolyzed Rhizobian Gum

Camellia Sinensis Leaf Extract

Chamomilla Recutita Flower Extract

PCA

Sodium PCA

Sh-Oligopeptide-1

Sh-Oligopeptide-2

Sh-Polypeptide-1

Sh-Polypeptide-11

Sh-Polypeptide-9

Acetyl Hexapeptide-8

Arginine

Aspartic Acid

Acetyl Glutamine

Carnitine

Alanine

Glycine

Histidine

Isoleucine

Phenylalanine

Proline

Serine

Threonine

Valine

Caffeine

Ruscus Aculeatus Root Extract

Chenopodium Quinoa Seed Extract

Bacillus

Citrus Reticulata Peel Extract

Codonopsis Lanceolata Extract

Coix Lacryma-Jobi Ma-Yuen Seed Extract

Chrysanthemum Parthenium Extract

Digitaria Ciliaris Flower Extract

Nelumbo Nucifera Seed Extract

Paeonia Suffruticosa Root Extract

Paeonia Albiflora Flower Extract

Polygonum Odoratum Extract

Sodium Lactate

Polyglutamic Acid

Xanthan Gum

1,2-Hexanediol

Citric Acid

Sodium Benzoate

Sodium Levulinate

Potassium Sorbate

Water, Niacinamide, Glycerin, Acacia Senegal Gum, Hydrolyzed Rhizobian Gum, Camellia Sinensis Leaf Extract, Chamomilla Recutita Flower Extract, PCA, Sodium PCA, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-11, Sh-Polypeptide-9, Sodium Hyaluronate, Acetyl Hexapeptide-8, Arginine, Aspartic Acid, Acetyl Glutamine, Lecithin, Carnitine, Alanine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Caffeine, Ruscus Aculeatus Root Extract, Chenopodium Quinoa Seed Extract, Bacillus, Citrus Reticulata Peel Extract, Codonopsis Lanceolata Extract, Coix Lacryma-Jobi Ma-Yuen Seed Extract, Chrysanthemum Parthenium Extract, Digitaria Ciliaris Flower Extract, Glycyrrhiza Glabra Root Extract, Nelumbo Nucifera Seed Extract, Paeonia Suffruticosa Root Extract, Paeonia Albiflora Flower Extract, Polygonum Odoratum Extract, Sodium Lactate, Polyglutamic Acid, Xanthan Gum, Butylene Glycol, 1,2-Hexanediol, Citric Acid, Caprylyl Glycol, Sodium Benzoate, Sodium Levulinate, Potassium Sorbate, Phenoxyethanol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 031,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
  4. 04It is a:
  5. 05Humectant, drawing moisture into the skin
  6. 06Emollient, helping to soften skin
  7. 07Solvent, dispersing and stabilizing formulas
  8. 08Preservative booster, enhancing the antimicrobial activity of other preservatives
  9. 09Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  10. 10Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  11. 11Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  12. 12Ceramide AP is is a skin-identical lipid that mimics what your skin already makes naturally. Ceramides help maintain epidermal integrity and barrier function.
  13. 13You'll often see this ingredient paired with other ceramides (like ceramide NP), cholesterol, or fatty acids because this combination best mimics the natural lipid mix your skin already has.
  14. 14The skin's ability to produce ceramides gets disrupted in skin conditions like eczema. This in turn weakens the skin barrier and applying ceramides topically has been shown to replenish what's been lost to restore barrier function.
  15. 15Most of the studies with Ceramide AP test it as part of a multi-ceramide complex; studies reinforce ceramide AP's role in rebalancing ceramides in skin and improving skin hydration.
  16. 16Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
  17. 17The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure …
  18. 18Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
  19. 19Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  20. 20Topically, glycerin does several things at once:
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

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