Paula's Choice Advanced Sun Protection Daily Moisturiser SPF 50 PA++++ Versus La Roche-Posay Anthelios Uvmune 400 Invisible Fluid SPF50+

Paula's Choice Advanced Sun Protection Daily Moisturiser SPF 50 PA++++ Versus La Roche-Posay Anthelios Uvmune 400 Invisible Fluid SPF50+

This chemical sunscreen covers the full UV range and blocks ~98% of UVB at SPF 50.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dibutyl Adipate

Diethylamino Hydroxybenzoyl Hexyl Benzoate

Propylheptyl Caprylate

Dicaprylyl Carbonate

Ethylhexyl Salicylate

Ethylhexyl Triazone

Methylene Bis-Benzotriazolyl Tetramethylbutylphenol

Undecane

Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine

Glycerin

Isononyl Isononanoate

Propanediol

Tridecane

Potassium Cetyl Phosphate

Saccharomyces Ferment

Sodium Polyacrylate

Decyl Glucoside

Caprylyl Glyceryl Ether

Sodium Phytate

Caprylhydroxamic Acid

Lauroyl Lysine

Propylene Glycol

Xanthan Gum

Tocopherol

Naringenin

Helianthus Annuus Seed Oil

Water, Dibutyl Adipate, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Propylheptyl Caprylate, Dicaprylyl Carbonate, Ethylhexyl Salicylate, Ethylhexyl Triazone, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, Undecane, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Glycerin, Isononyl Isononanoate, Propanediol, Tridecane, Potassium Cetyl Phosphate, Saccharomyces Ferment, Sodium Polyacrylate, Decyl Glucoside, Caprylyl Glyceryl Ether, Sodium Phytate, Caprylhydroxamic Acid, Lauroyl Lysine, Propylene Glycol, Xanthan Gum, Tocopherol, Naringenin, Helianthus Annuus Seed Oil

Alcohol Denat.

Triethyl Citrate

Diisopropyl Sebacate

Silica

Butyl Methoxydibenzoylmethane

C12-22 Alkyl Acrylate/Hydroxyethylacrylate Copolymer

Sodium Citrate

Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate

Perlite

Caprylic/Capric Triglyceride

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Caprylyl Glycol

Citric Acid

Drometrizole Trisiloxane

Hydroxyethylcellulose

Terephthalylidene Dicamphor Sulfonic Acid

Triethanolamine

Trisodium Ethylenediamine Disuccinate

Water, Alcohol Denat., Triethyl Citrate, Diisopropyl Sebacate, Silica, Ethylhexyl Salicylate, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Ethylhexyl Triazone, Butyl Methoxydibenzoylmethane, Glycerin, Propanediol, C12-22 Alkyl Acrylate/Hydroxyethylacrylate Copolymer, Sodium Citrate, Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate, Perlite, Tocopherol, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Glycol, Citric Acid, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Drometrizole Trisiloxane, Hydroxyethylcellulose, Terephthalylidene Dicamphor Sulfonic Acid, Triethanolamine, Trisodium Ethylenediamine Disuccinate

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is better known as bemotrizinol or Tinosorb S and is one of the best broad-spectrum UV filters in modern sunscreen.

It works by absorbing UV light across a whole range (280-400 nm) with peaks around 310 nm (UVB) and 340-345 nm (UVA). This means it covers UVB plus the deeper UVA wavelengths that drive photoaging and pigmentation.

Another pro?

It's exceptionally photostable, barely degrades in sunlight, and acts as a "bodyguard" for less stable filters.

That's why you'll see it paired with avobenzone or octinoxate; this team up ensures they keep working through sun exposure.

Safety reviews have been reassuring across the board. This ingredient shows low absorption through the skin, rarely irritates, and lab studies found it doesn't act like a hormone in the body (a concern that's been raised about some older sunscreen filters).

On maximum concentrations:

In 2026, the US F.D.A finally added it as an OTC sunscreen ingredient at concentrations up to 6% for adults / children 6 months and older

Diethylamino Hydroxybenzoyl Hexyl Benzoate (DHHB) is a chemical UV-A absorber. It is formulated for high UVA protection (320-400 nm).

DHHB is well-liked for:

DHHB has been approved by the EU, Japan, Taiwan, and South America for use up to 10%. Unfortunately, it has not been approved for use in the US or Canada due to slow regulatory processes.

This ingredient is soluble in oils, fats, and lipids.

Ethylhexyl Salicylate (also called Octisalate or Octyl Salicylate) is an oil-soluble organic UV filter that's been used in sunscreen since the 1950's.

It absorbs UVB light in the 280-320 nm range with a peak absorbance around 306 nm.

You'll often see it paired with other UV filters to boost overall SPF because octisalate is a fairly week filter on its own.

The reason you'll see it so often is because it can help solubilize and stabilize the trickier filters like oxybenzone and avobenzone.

Unlike these filters, octisalate has pretty good photostability and doesn't create skin-damaging free radicals when exposed to sunlight.

The fatty-alcohol part of the molecule also gives it a light, emollient feel so it doubles as a nice texture enhancer.

Usage levels vary around the world:

Safety-wise, this ingredient has a pretty reassuring track record. The EU's Scientific Committee on Consumer Products (SCCP) found very low skin penetration in human skin tests and negative results for irritation, phototoxicity, and photoallergy.

The real-world allergy risk is pretty low too; a 2012 European study of 1,031 people recorded only 2 reactions to it (a rate of 0.19%).

You might have seen scary headlines about sunscreen getting into your blood.

In 2019, the FDA found that several chemical filters can absorb through the skin and show up in the bloodstream at small but measurable levels.

Here's the important part: these tiny levels are just a cutoff the FDA uses to decide which ingredients need more testing and doesn't mean anything harmful was found.

The researchers were clear that the results are no reason to stop wearing sunscreen.

Ethylhexyl Triazone (aka Octyl Triazone) is an oil-soluble organic UVB filter. It has peak absorption around 314 nm, right in the middle of the UVB range.

This ingredient is described as one of the most effective UVB filters available and small concentrations are enough to deliver a high SPF thanks to its strong UV absorbing power.

Formulators love it for its stability; its ability to filter UV stays practically unchanged even under intense radiation and it can also help boost the photostability of less stable filters like avobenzone.

It's also a great pick for water resistant products because it's insoluble in water and has a good affinity for keratin.

Because it's a big, heavy molecule, the European Scientific Committee has found to to have very low dermal penetration and negative results for allergenicity.

In vitro testing also showed a low absorption rate and clean results on irritation.

Typical use levels are 1-5% with 5% being the maximum in the EU, Japan, and other markets that allow it. However, this ingredient is not approved yet in the US or Canada.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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