Skin science article
Paula's Choice Calm Redness Relief Toner for Normal to Dry Skin Versus Paula's Choice Resist Weightless Advanced Repairing Toner
Paula's Choice Calm Redness Relief Toner for Normal to Dry Skin Versus Paula's Choice Resist Weightless Advanced Repairing Toner This calming toner is formulated around Allantoin and Dipotassium Glycyrrhizate to calm redness and hydrate skin. This anti-aging t
Paula's Choice Calm Redness Relief Toner for Normal to Dry Skin Versus Paula's Choice Resist Weightless Advanced Repairing Toner
This calming toner is formulated around Allantoin and Dipotassium Glycyrrhizate to calm redness and hydrate skin.
This anti-aging toner is formulated around Niacinamide and Acetyl Glucosamine to soften the look of wrinkles and strengthen the skin barrier.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Cyclopentasiloxane
Glycereth-26
Allantoin
Genistein
Carnosine
Dipotassium Glycyrrhizate
Epigallocatechin Gallate
Glycyrrhiza Glabra Root Extract
Boerhavia Diffusa Root Extract
Caprylic/Capric Triglyceride
Dimethiconol
Sodium Hyaluronate
Oleic Acid
Linolenic Acid
Palmitic Acid
Linoleic Acid
Phospholipids
Epilobium Angustifolium Flower/Leaf/Stem Extract
Polysorbate 20
Hydrogenated Lecithin
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Xanthan Gum
Laureth-4
Laureth-23
Sodium Hydroxide
Butylene Glycol
Disodium EDTA
Ethylhexylglycerin
Phenoxyethanol
Water, Glycerin, Cyclopentasiloxane, Glycereth-26, Allantoin, Genistein, Carnosine, Dipotassium Glycyrrhizate, Epigallocatechin Gallate, Glycyrrhiza Glabra Root Extract, Boerhavia Diffusa Root Extract, Caprylic/Capric Triglyceride, Dimethiconol, Sodium Hyaluronate, Oleic Acid, Linolenic Acid, Palmitic Acid, Linoleic Acid, Phospholipids, Epilobium Angustifolium Flower/Leaf/Stem Extract, Polysorbate 20, Hydrogenated Lecithin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Laureth-4, Laureth-23, Sodium Hydroxide, Butylene Glycol, Disodium EDTA, Ethylhexylglycerin, Phenoxyethanol
Ethoxydiglycol
Niacinamide
Acetyl Glucosamine
Salix Nigra Bark Extract
Resveratrol
Palmitoyl Tetrapeptide-7
Palmitoyl Tripeptide-1
Adenosine
Citric Acid
Carbomer
Tetrasodium EDTA
Water, Glycerin, Ethoxydiglycol, Niacinamide, Acetyl Glucosamine, Salix Nigra Bark Extract, Resveratrol, Sodium Hyaluronate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Phospholipids, Epigallocatechin Gallate, Carnosine, Genistein, Glycyrrhiza Glabra Root Extract, Adenosine, Xanthan Gum, Citric Acid, Polysorbate 20, Butylene Glycol, Ethylhexylglycerin, Carbomer, Tetrasodium EDTA, Phenoxyethanol
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Carnosine is a dipeptide made from two amino acids.
This ingredient helps:
Glycation is the process of sugars binding to and damaging proteins. Too much sugar in our skin can lead to damaged collagen, contributing to factors of aging.
Carnosine is water-soluble and is not able to travel deeper layers of skin. This leads to some doubt about whether it can boost collagen in skin, since collagen is located in the deeper layers of skin.
Fun fact: Carnosine can be naturally found in our muscles and brain.
Epigallocatechin Gallate (EGCG) is the most abundant catechin in green tea. It is a heavyweight antioxidant in the green tea family.
In skincare, it helps protect skin from photoaging damage by scavenging UV-induced reactive oxygen species and tampering down inflammatory pathways.
UV-exposed skin cells treated with EGCG showed less of the enzyme that chews up collagen, lower inflammatory signaling, and better preserved barrier function.
EGCG nudges skin cells to make more of your skin's built in moisturizing molecules, filaggrin and hyaluronic acid, for better skin hydration.
Because it inhibits melanogenesis, it also provides a mild brightening effect.
Clinically, topical EGCG has helped calm radiation-related skin irritation and scalp seborrheic dermatitis with no major side effects.
In an 8-week split-face study, topical EGCG at 1% and 5% significantly reduced inflammatory and non-inflammatory acne.
A study from 2023 on patients with Seborrhea (a chronic skin condition caused by overactive sebaceous glands) found that using a 5% EGCG cream (alone and combined with 2% L-carnitine) and found meaningful sebum reduction plus better hydration.
Just one caveat here: Most clinical trials used 1-5% concentrations and most cosmetics contain only 0.1-1%.
The only headache related to this ingredient is stability. EGCG degrades quickly with heat, light, oxygen, and higher pH.
That's why you'll usually see it in low-pH formulas (4.5-6.5) or paired with vitamin C + vitamin E to slow its degradation. Hyaluronic acid also stabilizes it and boosts its antioxidant activity.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
We don't have a description for Genistein yet.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.
One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.
Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.
Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.
Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Phospholipids are a family of skin-identical lipids that makeup the structural backbone of every cell membrane in your body.
In cosmetics, they function as skin conditioning agents with emulsifier and surfactant properties. They're typically sourced from soybean or sunflower lecithin (or sometimes egg yolk or marine sources).
Because they mirror the lipids naturally found in the deeper layers of your skin, topical phospholipids help reinforce the lipid matrix, reduce transepidermal water loss, and leave skin feeling conditioned.
They're also used to form liposomes, or tiny self-assembling vesible used to stabilize actives like vitamin c or retinol. This helps these ingredients integrate into the upper layers of skin more easily.
Phospholipids are compatible with everything and the CIR Expert Panel has concluded them to be safe at current use levels.
Some types of phospholipids include:
Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.