Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Paula's Choice Calm Ultra-Gentle Cleanser Versus Paula's Choice Defense Hydrating Gel-To-Cream Cleanser

Paula's Choice Calm Ultra-Gentle Cleanser Versus Paula's Choice Defense Hydrating Gel-To-Cream Cleanser This mild gel cleanser is made to cleanse while calming and soothing your skin. This mild gel cleanser is made to cleanse without leaving your skin tight or

Paula's Choice Calm Ultra-Gentle Cleanser Versus Paula's Choice Defense Hydrating Gel-To-Cream Cleanser

This mild gel cleanser is made to cleanse while calming and soothing your skin.

This mild gel cleanser is made to cleanse without leaving your skin tight or dry.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Sodium Cocoyl Glutamate

Glycerin

Caprylic/Capric Triglyceride

Cocamidopropyl Betaine

Sodium Laurylglucosides Hydroxypropylsulfonate

Cellulose Gum

Coco-Caprylate/Caprate

Hydroxyacetophenone

Inulin

Xanthan Gum

Ethylhexylglycerin

Sodium Phytate

Cellulose

Fructose

Glucose

Phenoxyethanol

Water, Sodium Cocoyl Glutamate, Glycerin, Caprylic/Capric Triglyceride, Cocamidopropyl Betaine, Sodium Laurylglucosides Hydroxypropylsulfonate, Cellulose Gum, Coco-Caprylate/Caprate, Hydroxyacetophenone, Inulin, Xanthan Gum, Ethylhexylglycerin, Sodium Phytate, Cellulose, Fructose, Glucose, Phenoxyethanol

Sodium Cocoyl Glycinate

Cocamidopropyl Hydroxysultaine

Sodium Lauroamphoacetate

Sorbeth-230 Tetraoleate

Decyl Glucoside

Pentylene Glycol

Sodium Chloride

Disodium Cocoyl Glutamate

Lauric Acid

Lactic Acid

Sodium Lauroyl Oat Amino Acids

Sorbitan Laurate

Disodium EDTA

Aloe Barbadensis Leaf Juice Powder

Cocoyl Proline

Sodium Citrate

Camellia Sinensis Leaf Extract

Glycyrrhiza Glabra Root

Sodium PCA

Sodium Lactate

Arginine

Glycine Soja Sterols

Linoleic Acid

Phospholipids

Aspartic Acid

PCA

Glycine

Alanine

Serine

Valine

Isoleucine

Proline

Threonine

Potassium Citrate

Lactoperoxidase

Histidine

Phenylalanine

Glucose Oxidase

Citric Acid

Potassium Sorbate

Sodium Benzoate

Water, Sodium Cocoyl Glycinate, Cocamidopropyl Hydroxysultaine, Sodium Lauroamphoacetate, Cocamidopropyl Betaine, Glycerin, Sorbeth-230 Tetraoleate, Decyl Glucoside, Pentylene Glycol, Sodium Chloride, Disodium Cocoyl Glutamate, Lauric Acid, Lactic Acid, Sodium Lauroyl Oat Amino Acids, Sorbitan Laurate, Sodium Cocoyl Glutamate, Disodium EDTA, Aloe Barbadensis Leaf Juice Powder, Caprylic/Capric Triglyceride, Cocoyl Proline, Sodium Citrate, Camellia Sinensis Leaf Extract, Glycyrrhiza Glabra Root, Sodium PCA, Sodium Lactate, Arginine, Glycine Soja Sterols, Linoleic Acid, Phospholipids, Aspartic Acid, PCA, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Potassium Citrate, Lactoperoxidase, Histidine, Phenylalanine, Glucose Oxidase, Citric Acid, Phenoxyethanol, Ethylhexylglycerin, Potassium Sorbate, Sodium Benzoate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Cocamidopropyl Betaine is a fatty acid created by mixing similar compounds in coconut oil and dimethylaminopropylamine, a compound with two amino groups.

This ingredient is a surfactant and cleanser. It helps gather the dirt, pollutants, and other impurities in your skin to be washed away. It also helps thicken a product and make the texture more creamy.

Being created from coconut oil means Cocamidopropyl Betaine is hydrating for the skin.

While Cocamidopropyl Betaine was believed to be an allergen, a study from 2012 disproved this. It found two compounds in unpure Cocamidopropyl Betaine to be the irritants: aminoamide and 3-dimethylaminopropylamine. High-grade and pure Cocamidopropyl Betaine did not induce allergic reactions during this study.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Cocoyl Glutamate is a gentle cleanser and surfactant. It is the sodium salt of the Cocoyl Glutamic Acid and comes from coconut oil. As a surfactant, it helps lift dirt and oil to be washed away.

Sodium Cocoyl Glutamate also has an emolliating effect and can help leave the skin feeling soft.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Side-by-side

  1. 01Water
  2. 02Aminomethyl Propanol
  3. 03Glycolic Acid
  4. 04Lactic Acid
  5. 05Mandelic Acid
  6. 06Isoamyl Laurate
  7. 07Tartaric Acid
  8. 08Propanediol
  9. 09Salicylic Acid
  10. 10Malic Acid
  11. 11Butylene Glycol
  12. 12Clitoria Ternatea Flower Extract
  13. 13Sodium Hyaluronate
  14. 14Glycyrrhetinic Acid
  15. 15Glycerin
  16. 16Tocopherol
  17. 17Bisabolol
  18. 18Allantoin
  19. 19Hydroxyethylcellulose
  20. 20Hydrogenated Lecithin
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side