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Skin science article

Paula's Choice Clear Oil-Free Moisturizer Versus Paula's Choice Pro-Collagen Peptide Plumping Moisturizer

Paula's Choice Clear Oil-Free Moisturizer Versus Paula's Choice Pro-Collagen Peptide Plumping Moisturizer This barrier-repair moisturizer is formulated around Niacinamide and Ceramide NP to strengthen the skin barrier and calm redness. This anti-aging moisturi

Paula's Choice Clear Oil-Free Moisturizer Versus Paula's Choice Pro-Collagen Peptide Plumping Moisturizer

This barrier-repair moisturizer is formulated around Niacinamide and Ceramide NP to strengthen the skin barrier and calm redness.

This anti-aging moisturizer is formulated around Squalane to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Ethyl Macadamiate

Glycerin

Cetearyl Alcohol

Propanediol

Triethylhexanoin

Sodium Acrylates Copolymer

Glyceryl Stearate

PEG-100 Stearate

Glycyrrhiza Glabra Root

Hydrolyzed Pumpkin Seedcake

Vaccinium Angustifolium Fruit Extract

Euterpe Oleracea Fruit Extract

Prunus Serotina Fruit Extract

Niacinamide

Tripeptide-29

Ceramide NP

Ceramide AP

Ceramide EOP

Sodium Hyaluronate

Phytosphingosine

Cholesterol

Panthenol

Sodium PCA

Adenosine

Lecithin

Arginine

Sodium Lauroyl Lactylate

Sodium Gluconate

Citric Acid

Isohexadecane

Xanthan Gum

Carbomer

Phenoxyethanol

Ethylhexylglycerin

Water, Ethyl Macadamiate, Glycerin, Cetearyl Alcohol, Propanediol, Triethylhexanoin, Sodium Acrylates Copolymer, Glyceryl Stearate, PEG-100 Stearate, Glycyrrhiza Glabra Root, Hydrolyzed Pumpkin Seedcake, Vaccinium Angustifolium Fruit Extract, Euterpe Oleracea Fruit Extract, Prunus Serotina Fruit Extract, Niacinamide, Tripeptide-29, Ceramide NP, Ceramide AP, Ceramide EOP, Sodium Hyaluronate, Phytosphingosine, Cholesterol, Panthenol, Sodium PCA, Adenosine, Lecithin, Arginine, Sodium Lauroyl Lactylate, Sodium Gluconate, Citric Acid, Isohexadecane, Xanthan Gum, Carbomer, Phenoxyethanol, Ethylhexylglycerin

Dimethicone

Squalane

Pyrus Malus Fruit Extract

Pentylene Glycol

1,2-Hexanediol

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Butylene Glycol

Hydroxyacetophenone

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Gigartina Stellata Extract

Acetyl Sh-Hexapeptide-5 Amide Acetate

Tridecapeptide-1

Oligopeptide-1

Sodium Phytate

Hydroxypropyltrimonium Hyaluronate

Cyanocobalamin

Water, Dimethicone, Squalane, Glycerin, Pyrus Malus Fruit Extract, Pentylene Glycol, 1,2-Hexanediol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Butylene Glycol, Hydroxyacetophenone, Sodium Acrylates Copolymer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Gigartina Stellata Extract, Acetyl Sh-Hexapeptide-5 Amide Acetate, Tridecapeptide-1, Oligopeptide-1, Sodium Phytate, Propanediol, Lecithin, Hydroxypropyltrimonium Hyaluronate, Cyanocobalamin, Phenoxyethanol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

This ingredient is a synthetic, salt form polymer built from acrylic acid, ethacrylic acid, or their simple esters. It works as a binder, film former, and viscosity increasing agent.

Typical concentrations start at around 0.5% but can go up to 25% for film-forming or binding.

The CIR Expert Panel assessed the safety of 126 acrylates copolymers and concluded they are safe in cosmetics at current use levels when formulated to be non-irritating. They also noted the levels present in finished cosmetic products are not considered a safety risk and Genotoxicity testing (Ames tests, chromosomal aberration assays) has come back negative across the board.

Though the raw building blocks (like acrylic acid) can be irritating on their own, cosmetic-grade versions go through purification to keep levels extremely low.

Sodium Acrylates Copolymer is a large molecule that doesn't penetrate skin barrier in any meaningful way.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Ammonium Acryloyldimethyltaurate/Vp Copolymer is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.
  4. 04Think of it as a supportive ingredient that helps your gel-creams feel silky, "cloud cream-like", and spread evenly without being greasy.
  5. 05The Cosmetic Ingredient Review (CIR) Expert Panel evaluated it (along with 22 other acryloyldimethyltaurate polymers) and concluded it's:
  6. 06Due to its large molecular size, it sits on the surface of skin rather than penetrating it.
  7. 07Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  8. 08Topically, glycerin does several things at once:
  9. 09Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  10. 10Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  11. 11This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  12. 12Just know very high concentrations (>40%) can feel tacky in low humidity.
  13. 13Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  14. 14Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.
  15. 15Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:
  16. 16It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.
  17. 17Oligopeptide-1 is another name for Epidermal Growth Factor (EGF). In a formula, EGF works as a signaling ingredient.
  18. 18EGF binds to receptors on your skin cells and tells keratinocytes/fibroblasts to divide, move, and rebuild the skin's support structure.
  19. 19A 2012 open-label study on a barley-derived EGF serum reported statistically significant improvements in fine-lines, skin texture, pore size, and uneven skin tone, with changes showing up within the first month of 2x/daily use.
  20. 20And a 2023 review found generally positive but modest results for growth factor products while pointing out that most trials are small, often industry-funded, and rarely test EGF on its own.
Source · skinsort.com
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Product index

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Comparison edit

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