Paula's Choice Defense Antioxidant Pore Purifier Versus Paula's Choice Resist Barrier Repair Moisturizer with Retinol

Paula's Choice Defense Antioxidant Pore Purifier Versus Paula's Choice Resist Barrier Repair Moisturizer with Retinol

This pore-care treatment is formulated around Ascorbyl Glucoside and Salicylic Acid to refine the look of pores and balance excess oil.

This barrier-repair moisturizer is formulated around Retinol and Ceramide NP to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Propanediol

Butylene Glycol

Ethoxydiglycol

Glycerin

Ascorbyl Glucoside

Panthenol

Salicylic Acid

Camellia Sinensis Callus

Glycyrrhiza Glabra Root Extract

Potassium Azeloyl Diglycinate

Coffea Arabica Fruit Extract

Ceramide NP

Vitis Vinifera Seed Extract

Panax Ginseng Root Extract

Niacinamide

Phytic Acid

Epigallocatechin Gallate

Adenosine

Ubiquinone

Calendula Officinalis Flower Extract

Lonicera Caprifolium Flower Extract

Sodium Hyaluronate

Lecithin

Centella Asiatica Extract

Sucrose Stearate

Glycine Soja Seed Extract

Hydrogenated Lecithin

Carbomer

Tetrasodium Glutamate Diacetate

Caprylic/Capric Triglyceride

Caprylyl Glycol

Polysorbate 20

Polyglyceryl-10 Stearate

Hydroxyethylcellulose

Sodium Hydroxide

Ethylhexylglycerin

Phenoxyethanol

Water, Propanediol, Butylene Glycol, Ethoxydiglycol, Glycerin, Ascorbyl Glucoside, Panthenol, Salicylic Acid, Camellia Sinensis Callus, Glycyrrhiza Glabra Root Extract, Potassium Azeloyl Diglycinate, Coffea Arabica Fruit Extract, Ceramide NP, Vitis Vinifera Seed Extract, Panax Ginseng Root Extract, Niacinamide, Phytic Acid, Epigallocatechin Gallate, Adenosine, Ubiquinone, Calendula Officinalis Flower Extract, Lonicera Caprifolium Flower Extract, Sodium Hyaluronate, Lecithin, Centella Asiatica Extract, Sucrose Stearate, Glycine Soja Seed Extract, Hydrogenated Lecithin, Carbomer, Tetrasodium Glutamate Diacetate, Caprylic/Capric Triglyceride, Caprylyl Glycol, Polysorbate 20, Polyglyceryl-10 Stearate, Hydroxyethylcellulose, Sodium Hydroxide, Ethylhexylglycerin, Phenoxyethanol

Dicaprylyl Carbonate

Ethylhexyl Stearate

Cocoglycerides

Butyrospermum Parkii Butter

Squalane

Sodium Polyacrylate

Palmitoyl Tripeptide-1

Retinol

Punica Granatum Extract

Camellia Oleifera Leaf Extract

Tetrahydrodiferuloylmethane

Tetrahydrodemethoxydiferuloylmethane

Tetrahydrobisdemethoxydiferuloylmethane

Tocopheryl Acetate

Chamomilla Recutita Flower Extract

Glycine Soja Oil

Propylene Glycol

Glyceryl Polymethacrylate

Xanthan Gum

Water, Dicaprylyl Carbonate, Glycerin, Ethylhexyl Stearate, Cocoglycerides, Butyrospermum Parkii Butter, Squalane, Sodium Polyacrylate, Lecithin, Adenosine, Palmitoyl Tripeptide-1, Ceramide NP, Retinol, Punica Granatum Extract, Camellia Oleifera Leaf Extract, Glycyrrhiza Glabra Root Extract, Tetrahydrodiferuloylmethane, Tetrahydrodemethoxydiferuloylmethane, Tetrahydrobisdemethoxydiferuloylmethane, Tocopheryl Acetate, Chamomilla Recutita Flower Extract, Glycine Soja Seed Extract, Glycine Soja Oil, Butylene Glycol, Propylene Glycol, Glyceryl Polymethacrylate, Xanthan Gum, Phenoxyethanol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glycine Soja Seed Extract comes from the seed of the wild soybean plant. Wild soybean extract contains fatty acids (linoleic, oleic, linolenic), vitamin E, and antioxidants.

The wild soybean contains soyasaponins, a bioactive compound. Soyasaponins have inflammatory, antimutagenic, anticarcinogenic, antimicrobial properties. Soyasaponin has also been found to inhibit the melanin-creation process.

Two powerful components found in the wild soybean include genistein and diadzein. These two isoflavones are potent antioxidants with anti-inflammatory properties. Genistein in particular has been found to prevent redness caused by UV exposure.

One study from South Korea found wild soybean extract to help promote hair growth at the cellular level.

The wild soybean plant is a cousin to the famous soybean that gives us tofu, soy milk, and soy sauce.

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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