Skin science article
Paula's Choice Earth Sourced Antioxidant Enriched Natural Moisturizer Versus Paula's Choice Omega+ Complex Moisturizer
Paula's Choice Earth Sourced Antioxidant Enriched Natural Moisturizer Versus Paula's Choice Omega+ Complex Moisturizer This barrier-repair moisturizer is formulated around Borago Officinalis Seed Oil and Sodium Hyaluronate to strengthen the skin barrier and hy
Paula's Choice Earth Sourced Antioxidant Enriched Natural Moisturizer Versus Paula's Choice Omega+ Complex Moisturizer
This barrier-repair moisturizer is formulated around Borago Officinalis Seed Oil and Sodium Hyaluronate to strengthen the skin barrier and hydrate skin.
This barrier-repair moisturizer is formulated around Butyrospermum Parkii Butter and Linoleic Acid to strengthen the skin barrier and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Theobroma Cacao Seed Butter
Glycerin
Vitis Vinifera
Canola Oil
Olea Europaea Fruit Oil
Butyrospermum Parkii Butter Unsaponifiables
Benzyl Alcohol
Propanediol
Borago Officinalis Seed Oil
Oenothera Biennis Oil
Sodium Hyaluronate
Rubus Idaeus Fruit Extract
Vaccinium Macrocarpon Fruit Extract
Vaccinium Myrtillus Fruit Extract
Malpighia Emarginata Fruit Extract
Lycium Barbarum Fruit Extract
Aloe Barbadensis Leaf Juice
Tocopherol
Hydrogenated Lecithin
Thermus Thermophillus Ferment
Linum Usitatissimum Seed Oil
Caprylic/Capric Triglyceride
Arginine
Glycine
Alanine
Serine
Valine
Proline
Threonine
Isoleucine
Histidine
Phenylalanine
Aspartic Acid
Helianthus Annuus Seed Oil
Carrageenan
Sodium Lactate
Sodium PCA
Silica
Xanthan Gum
Leuconostoc/Radish Root Ferment Filtrate
Caprylyl Glycol
Glyceryl Stearate
PCA
Phenoxyethanol
Potassium Sorbate
Sodium Benzoate
Water, Theobroma Cacao Seed Butter, Glycerin, Vitis Vinifera, Canola Oil, Olea Europaea Fruit Oil, Butyrospermum Parkii Butter Unsaponifiables, Benzyl Alcohol, Propanediol, Borago Officinalis Seed Oil, Oenothera Biennis Oil, Sodium Hyaluronate, Rubus Idaeus Fruit Extract, Vaccinium Macrocarpon Fruit Extract, Vaccinium Myrtillus Fruit Extract, Malpighia Emarginata Fruit Extract, Lycium Barbarum Fruit Extract, Aloe Barbadensis Leaf Juice, Tocopherol, Hydrogenated Lecithin, Thermus Thermophillus Ferment, Linum Usitatissimum Seed Oil, Caprylic/Capric Triglyceride, Arginine, Glycine, Alanine, Serine, Valine, Proline, Threonine, Isoleucine, Histidine, Phenylalanine, Aspartic Acid, Helianthus Annuus Seed Oil, Carrageenan, Sodium Lactate, Sodium PCA, Silica, Xanthan Gum, Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Glyceryl Stearate, PCA, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate
Butyrospermum Parkii Butter
Ceteareth-6 Olivate
Butylene Glycol
C13-15 Alkane
Polyglyceryl-4 Laurate
Decyl Oleate
Salvia Hispanica Seed Oil
Passiflora Edulis Seed Oil
Hydrogenated Olive Oil
Psidium Guajava Fruit Extract
Olea Europaea Oil Unsaponifiables
Limnanthes Alba Seed Oil
Linoleic Acid
Linolenic Acid
Oleic Acid
Euterpe Oleracea Sterols
Ceramide AP
Ceramide EOP
Ceramide NP
Lysine Hcl
Squalane
Cholesterol
Phytosphingosine
Anastatica Hierochuntica Extract
Lecithin
Boerhavia Diffusa Root Extract
Adenosine
Phytic Acid
Glutamic Acid
Betaine
Pullulan
Carbomer
Sodium Polyacrylate Starch
Sclerotium Gum
Sodium Lauroyl Lactylate
Ethylhexylglycerin
Water, Butyrospermum Parkii Butter, Ceteareth-6 Olivate, Butylene Glycol, C13-15 Alkane, Glycerin, Glyceryl Stearate, Polyglyceryl-4 Laurate, Decyl Oleate, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Olea Europaea Fruit Oil, Passiflora Edulis Seed Oil, Borago Officinalis Seed Oil, Hydrogenated Olive Oil, Psidium Guajava Fruit Extract, Olea Europaea Oil Unsaponifiables, Limnanthes Alba Seed Oil, Linoleic Acid, Linolenic Acid, Oleic Acid, Euterpe Oleracea Sterols, Ceramide AP, Ceramide EOP, Ceramide NP, Serine, Alanine, Glycine, Proline, Lysine Hcl, Threonine, Arginine, Squalane, Cholesterol, Phytosphingosine, Anastatica Hierochuntica Extract, Lecithin, Sodium Hyaluronate, Sodium Lactate, Boerhavia Diffusa Root Extract, Adenosine, Phytic Acid, Glutamic Acid, Betaine, Pullulan, PCA, Sodium PCA, Carbomer, Sodium Polyacrylate Starch, Sclerotium Gum, Xanthan Gum, Sodium Lauroyl Lactylate, Phenoxyethanol, Ethylhexylglycerin
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Alanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.
Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.
It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.
A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.
Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.
One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.
Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.
Borago Officinalis Seed Oil is from the seeds of the starflower plant. This plant grows primarily in Europe.
This oil does not have a scent. It contains fatty acids such as linolenic acid. These fatty acids help keep skin hydrated.
Borago Officinalis Seed Oil is an antioxidant. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Glycine is the smallest amino acid and a key building block of collagen. It's part if your skin's Natural Moisturizing Factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
A study from 2022 found that an amino acid complex featuring taurine, arginine, and glycine significantly reduced skin irritation, improved redness, and accelerated the skin repair process.
This ingredient is also known as flaxseed oil or linseed oil. It is created by cold-pressing the seeds of the flax plant and is rich in fatty acids.
This oil is packed with omega-3 (ALA), omega-6, and omega-9 fatty acids that closely mimic the skin's own natural lipid barrier. The high omega-3 content gives it solid anti-inflammatory properties.
Clinical studies have found it can reduce water loss and improve smoothness/hydration, particularly in sensitive skin types. Studies also suggest it helps maintain the lipid layer that is compromised in atopic (eczema-prone) skin.
Wound healing studies showed that low-concentration linseed oil formulations (1-5%) produced significant barrier repair, but it should be noted that high concentrations showed diminishing returns.
Due to the rich fatty acid content, this ingredient may not be fungal acne safe.
This ingredient is also known as olive oil. It has been used in skincare for centuries and science largely backs up its reputation as a nourishing emollient.
The main components of olive oil are oleic acid (55-83%), linoleic acid (3.5-20%), and palmitic acid (7-20%). Oleic acid promotes skin regeneration and helps regulate inflammatory responses.
Squalene is also naturally present in olive oil and exhibits moisturizing and antioxidant properties.
The polyphenols in olive oil also show anti-aging promise; one clinical study found a measurable improvement in skin appearance after 30 days of topical serum use.
Just be aware that applying olive oil directly to skin can weaken the barrier and cause redness. One study with volunteers found even people without sensitive skin experienced a significant reduction in stratum corneum integrity and induced mild erythema.
It's best to use this ingredient as part of a carefully crafted formula (instead of putting it on skin directly from the bottle).
Because it has a 2-3 on the comedogenic scale, it is a moderate risk for acne-prone skin. However, the overall formulation of a product matters more than a few ingredients with comedogenic ratings.
This ingredient may not be fungal acne safe because of the oleic and palmitic acid content. These fall within the C11-24 fatty acid range that the Malassezia yeast can metabolize to grow.
Overall, olive oil is a well-studied and nourishing skincare ingredient.
PCA is an amino acid derivative and one of the star players in your skin's own Natural Moisturizing Factor (NMF).
The NMF is the built-in cocktail of small molecules that keeps your outer layer of skin hydrated and your body makes it naturally.
This is why it works so well topically; PCA is a humectant that holds water in the stratum corneum and studies link higher skin PCA levels to better hydration + lower water loss. Interestingly, people show more PCA in summer and in normal vs dry skin.
Most of the benefits of this ingredient are related to hydration, softness, and barrier support.
A long-running review found that formulas with at least 2% PCA or its salts improved dry skin over both the short and long term. And the zinc salt is also used for its mild antimicrobial and astringent properties.
The salt forms are more common in cosmetics (like sodium PCA).
This ingredient is compatible with basically everything and pairs well with other humectants like glycerin or hyaluronic acid.
Usage-wise, it's typically used at low percentages (~0.2-2%).
The Cosmetic Ingredient Review Expert Panel has concluded PCA and its salts are safe as used and is non-irritating on skin even at high concentrations.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.
It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.
Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.
Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.
Serine is a non-essential amino acid (your body makes it on its own!). It is a major player in your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
Serine is one of your NMF's most abundant components that works as a skin-identical humectant. Its hydroxyl group grabs onto water molecules to boost hydration without any heaviness or occlusion.
Research on a hydrogel with serine confirmed this serine got delivered to your stratum corneum and demonstrated enhanced skin moisturization.
Interestingly serine also helps your skin produce filaggrin, a protein that keeps your skin barrier strong and used to create collagen.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and sometimes used to adjust the pH of a product.
This ingredient is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin. NMF also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.
High percentages of Sodium Lactate can have an exfoliating effect.
Fun fact: Sodium Lactate is produced from fermented sugar.
Sodium PCA (the salt of PCA) is one of the most well-established humectants in skincare.
Why is it so special? Your skin already makes it naturally; it's a natural component of your skin's Natural Moisturizing Factor (NMF), or the mix of water-binding compounds inside your skin cells that keeps things soft and hydrated.
As a cosmetic ingredient, it grabs water and holds it in the upper layers of skin to smooth roughness and ease dehydration.
There's some clinical support for the NMF approach with a study showing that a cream built to mimic the skin's NMF significantly boosted hydration.
Safety-wise, this ingredient non-irritating, non-comedogenic, and non-phototoxic in testing, with minimal skin absorption.
It also works really well with other hydrators like glycerin or hyaluronic acid, and typical usage is somewhere between 0.2-4%.
Threonine is an amino-acid. It helps hydrate the skin and has antioxidant benefits.
Our skin uses threonine for creating collagen and elastin. Humans are not able to create threonine and must get it through eating foods such as fish, lentils, poultry, sesame seeds, and more.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.