Skin science article
Paula's Choice Moisture Boost Hydrating Treatment Cream Versus SkinCeuticals Triple Lipid Restore 2:4:2
Paula's Choice Moisture Boost Hydrating Treatment Cream Versus SkinCeuticals Triple Lipid Restore 2:4:2 This barrier-repair moisturizer is formulated around Simmondsia Chinensis Seed Oil and Sodium Hyaluronate to strengthen the skin barrier and hydrate skin. T
Paula's Choice Moisture Boost Hydrating Treatment Cream Versus SkinCeuticals Triple Lipid Restore 2:4:2
This barrier-repair moisturizer is formulated around Simmondsia Chinensis Seed Oil and Sodium Hyaluronate to strengthen the skin barrier and hydrate skin.
This barrier-repair moisturizer is formulated around Cholesterol and Ceramide NP to strengthen the skin barrier and soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Ethylhexyl Stearate
Simmondsia Chinensis Seed Oil
Butylene Glycol
Glycerin
Petrolatum
Cetearyl Alcohol
Dipentaerythrityl Hexacaprylate/Hexacaprate
Tridecyl Trimellitate
Sodium Hyaluronate
Ceramide NP
Cholesterol
Tocopherol
Squalane
Magnesium Ascorbyl Phosphate
Dimethicone
Niacinamide
Polysorbate 60
Hydrolyzed Jojoba Protein
Hydrolyzed Wheat Protein
Avena Sativa Kernel Extract
Hydrogenated Lecithin
Whey Protein
Tridecyl Stearate
Neopentyl Glycol Dicaprylate/Dicaprate
Phenyl Trimethicone
Myristyl Myristate
Linoleic Acid
Linolenic Acid
Decarboxy Carnosine Hcl
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Cetearyl Glucoside
Cetyl Alcohol
Polyglyceryl-3 Beeswax
Aminomethyl Propanol
Disodium EDTA
Benzoic Acid
Chlorphenesin
Sorbic Acid
Phenoxyethanol
Water, Ethylhexyl Stearate, Simmondsia Chinensis Seed Oil, Butylene Glycol, Glycerin, Petrolatum, Cetearyl Alcohol, Dipentaerythrityl Hexacaprylate/Hexacaprate, Tridecyl Trimellitate, Sodium Hyaluronate, Ceramide NP, Cholesterol, Tocopherol, Squalane, Magnesium Ascorbyl Phosphate, Dimethicone, Niacinamide, Polysorbate 60, Hydrolyzed Jojoba Protein, Hydrolyzed Wheat Protein, Avena Sativa Kernel Extract, Hydrogenated Lecithin, Whey Protein, Tridecyl Stearate, Neopentyl Glycol Dicaprylate/Dicaprate, Phenyl Trimethicone, Myristyl Myristate, Linoleic Acid, Linolenic Acid, Decarboxy Carnosine Hcl, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Cetearyl Glucoside, Cetyl Alcohol, Polyglyceryl-3 Beeswax, Aminomethyl Propanol, Disodium EDTA, Benzoic Acid, Chlorphenesin, Sorbic Acid, Phenoxyethanol
Hydrogenated Polyisobutene
C12-15 Alkyl Benzoate
Helianthus Annuus Seed Oil Unsaponifiables
Bis-PEG-18 Methyl Ether Dimethyl Silane
Sodium Polyacrylate
PEG-10 Dimethicone
Nylon-12
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
Dimethicone/PEG-10/15 Crosspolymer
Disteardimonium Hectorite
Hydroxyethylpiperazine Ethane Sulfonic Acid
Ammonium Polyacryloyldimethyl Taurate
Caprylyl Glycol
PEG/PPG-18/18 Dimethicone
Propylene Carbonate
Acrylonitrile/Methyl Methacrylate/Vinylidene Chloride Copolymer
Adenosine
Dipropylene Glycol
Lavandula Angustifolia Oil
Rosmarinus Officinalis Leaf Oil
T-Butyl Alcohol
Mentha Piperita Oil
Sodium Citrate
Linalool
Isobutane
Ceramide EOP
BHT
Limonene
Water, Dimethicone, Hydrogenated Polyisobutene, Glycerin, Cholesterol, C12-15 Alkyl Benzoate, Ceramide NP, Helianthus Annuus Seed Oil Unsaponifiables, Bis-PEG-18 Methyl Ether Dimethyl Silane, Sodium Polyacrylate, PEG-10 Dimethicone, Nylon-12, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Dimethicone/PEG-10/15 Crosspolymer, Phenoxyethanol, Disteardimonium Hectorite, Hydroxyethylpiperazine Ethane Sulfonic Acid, Ammonium Polyacryloyldimethyl Taurate, Chlorphenesin, Caprylyl Glycol, PEG/PPG-18/18 Dimethicone, Propylene Carbonate, Disodium EDTA, Acrylonitrile/Methyl Methacrylate/Vinylidene Chloride Copolymer, Adenosine, Dipropylene Glycol, Lavandula Angustifolia Oil, Rosmarinus Officinalis Leaf Oil, T-Butyl Alcohol, Mentha Piperita Oil, Sodium Citrate, Linalool, Isobutane, Ceramide EOP, BHT, Tocopherol, Limonene
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.
Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.
This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.
A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.
Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.
Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.
Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.
Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.
Chlorphenesin is a biocide. This means it is able to help fight the microorganisms on our skin. It is also able to fight odor-releasing bacteria.
Chlorphenesin is soluble in both water and glycerin.
Studies show Chlorphenesin is easily absorbed by our skin. You should speak with a skincare professional if you have concerns about using Chlorphenesin.
Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.
It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).
This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.
Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.
Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.
Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!