Paula's Choice Peptide Booster Versus Cos De BAHA Peptide Complex Facial Cream with Matrixyl 3000 & Argireline

Paula's Choice Peptide Booster Versus Cos De BAHA Peptide Complex Facial Cream with Matrixyl 3000 & Argireline

This anti-aging treatment is formulated around Tripeptide-1 and Palmitoyl Tripeptide-1 to soften the look of wrinkles and refine skin texture.

This anti-aging moisturizer is formulated around Acetyl Hexapeptide-8 and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

PEG-8 Dimethicone

Tripeptide-1

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Palmitoyl Hexapeptide-12

Myristoyl Hexapeptide-16

Myristoyl Pentapeptide-17

Hexanoyl Dipeptide-3 Norleucine Acetate

Azelaoyl Bis-Dipeptide-10

Glycoproteins

Phospholipids

Adenosine

Dipotassium Glycyrrhizate

Arginine

Valine

Glycine

Alanine

Glutamic Acid

Serine

Threonine

Yeast Extract

Isoleucine

Proline

Histidine

Phenylalanine

PCA

Phytic Acid

Panax Ginseng Root Extract

Sodium PCA

Psidium Guajava Fruit Extract

Euterpe Oleracea Fruit Extract

Ahnfeltiopsis Concinna Extract

Dextran

Hydrolyzed Silk

Lecithin

Glyceryl Polymethacrylate

C12-16 Pareth-9

Trideceth-12

Sodium Lactate

Carbomer

Aspartic Acid

Polysorbate 20

Butylene Glycol

Caprylyl Glycol

PEG-8

C11-15 Pareth-7

Guar Hydroxypropyltrimonium Chloride

Phytosteryl/Octyldodecyl Lauroyl Glutamate

Ectoin

Citrate Buffer

Trimethylsiloxyamodimethicone

Phenoxyethanol

Sodium Hydroxide

Ethylhexylglycerin

Water, Glycerin, PEG-8 Dimethicone, Tripeptide-1, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Myristoyl Hexapeptide-16, Myristoyl Pentapeptide-17, Hexanoyl Dipeptide-3 Norleucine Acetate, Azelaoyl Bis-Dipeptide-10, Glycoproteins, Phospholipids, Adenosine, Dipotassium Glycyrrhizate, Arginine, Valine, Glycine, Alanine, Glutamic Acid, Serine, Threonine, Yeast Extract, Isoleucine, Proline, Histidine, Phenylalanine, PCA, Phytic Acid, Panax Ginseng Root Extract, Sodium PCA, Psidium Guajava Fruit Extract, Euterpe Oleracea Fruit Extract, Ahnfeltiopsis Concinna Extract, Dextran, Hydrolyzed Silk, Lecithin, Glyceryl Polymethacrylate, C12-16 Pareth-9, Trideceth-12, Sodium Lactate, Carbomer, Aspartic Acid, Polysorbate 20, Butylene Glycol, Caprylyl Glycol, PEG-8, C11-15 Pareth-7, Guar Hydroxypropyltrimonium Chloride, Phytosteryl/Octyldodecyl Lauroyl Glutamate, Ectoin, Citrate Buffer, Trimethylsiloxyamodimethicone, Phenoxyethanol, Sodium Hydroxide, Ethylhexylglycerin

Aloe Barbadensis Leaf Extract

Propanediol

Caprylic/Capric Triglyceride

Niacinamide

1,2-Hexanediol

Cetearyl Olivate

Cetearyl Alcohol

Glyceryl Stearate

Sorbitan Olivate

Panthenol

Acetyl Hexapeptide-8

Tocopheryl Acetate

Butyrospermum Parkii Butter

Argania Spinosa Kernel Oil

Caffeine

Allantoin

Sodium Hyaluronate

Squalane

Ceramide NP

Rosa Damascena Extract

Lavandula Angustifolia Flower Extract

Camellia Sinensis Leaf Extract

Melissa Officinalis Leaf Extract

Artemisia Vulgaris Extract

Sorbitan Isostearate

Polysorbate 60

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Aloe Barbadensis Leaf Extract, Propanediol, Caprylic/Capric Triglyceride, Niacinamide, 1,2-Hexanediol, Cetearyl Olivate, Cetearyl Alcohol, Glyceryl Stearate, Sorbitan Olivate, Panthenol, Acetyl Hexapeptide-8, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Tocopheryl Acetate, Butyrospermum Parkii Butter, Argania Spinosa Kernel Oil, Caffeine, Allantoin, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Squalane, Ceramide NP, Adenosine, Rosa Damascena Extract, Lavandula Angustifolia Flower Extract, Camellia Sinensis Leaf Extract, Melissa Officinalis Leaf Extract, Artemisia Vulgaris Extract, Sorbitan Isostearate, Polysorbate 60, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Dipotassium Glycyrrhizate comes from licorice root.

Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.

Palmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a synthetic peptide. Its main job is to fight what researchers call "inflammaging".

"Inflammaging" is the slow, low-grade chronic inflammation that quietly breaks down collagen as we age.

This ingredient calms down a specific inflammation signal in your skin cells (called IL-6). When left unchecked, this signal triggers enzymes that break down collagen and elastin.

Clinical testing showed statistically significant improvements in:

Studies also found the more of this ingredient used, the more your skin produces Collagen I, fibronectin, and hyaluronic acid.

You'll likely see this ingredient paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.

A 3% concentration applied twice daily for two months showed meaningful skin rejuvenation results in clinical panels.

Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.

Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid.

That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference.

Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.

In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing.

Human clinical data is promising, but modest:

A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm.

A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks.

You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex.

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