Skin science article
Paula's Choice Peptide Booster Versus Paula's Choice Resist Super Antioxidant Serum
Paula's Choice Peptide Booster Versus Paula's Choice Resist Super Antioxidant Serum This anti-aging treatment is formulated around Tripeptide-1 and Palmitoyl Tripeptide-1 to soften the look of wrinkles and refine skin texture. This anti-aging serum is formulat
Paula's Choice Peptide Booster Versus Paula's Choice Resist Super Antioxidant Serum
This anti-aging treatment is formulated around Tripeptide-1 and Palmitoyl Tripeptide-1 to soften the look of wrinkles and refine skin texture.
This anti-aging serum is formulated around Tetrahexyldecyl Ascorbate and Palmitoyl Tripeptide-5 to soften the look of wrinkles and brighten dull-looking skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
PEG-8 Dimethicone
Tripeptide-1
Palmitoyl Tripeptide-1
Palmitoyl Tetrapeptide-7
Palmitoyl Hexapeptide-12
Myristoyl Hexapeptide-16
Myristoyl Pentapeptide-17
Hexanoyl Dipeptide-3 Norleucine Acetate
Azelaoyl Bis-Dipeptide-10
Glycoproteins
Phospholipids
Adenosine
Dipotassium Glycyrrhizate
Arginine
Valine
Glycine
Alanine
Glutamic Acid
Serine
Threonine
Yeast Extract
Isoleucine
Proline
Histidine
Phenylalanine
PCA
Phytic Acid
Panax Ginseng Root Extract
Sodium PCA
Psidium Guajava Fruit Extract
Euterpe Oleracea Fruit Extract
Ahnfeltiopsis Concinna Extract
Dextran
Hydrolyzed Silk
Lecithin
Glyceryl Polymethacrylate
C12-16 Pareth-9
Trideceth-12
Sodium Lactate
Carbomer
Aspartic Acid
Polysorbate 20
Butylene Glycol
Caprylyl Glycol
PEG-8
C11-15 Pareth-7
Guar Hydroxypropyltrimonium Chloride
Phytosteryl/Octyldodecyl Lauroyl Glutamate
Ectoin
Citrate Buffer
Trimethylsiloxyamodimethicone
Phenoxyethanol
Sodium Hydroxide
Ethylhexylglycerin
Water, Glycerin, PEG-8 Dimethicone, Tripeptide-1, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Myristoyl Hexapeptide-16, Myristoyl Pentapeptide-17, Hexanoyl Dipeptide-3 Norleucine Acetate, Azelaoyl Bis-Dipeptide-10, Glycoproteins, Phospholipids, Adenosine, Dipotassium Glycyrrhizate, Arginine, Valine, Glycine, Alanine, Glutamic Acid, Serine, Threonine, Yeast Extract, Isoleucine, Proline, Histidine, Phenylalanine, PCA, Phytic Acid, Panax Ginseng Root Extract, Sodium PCA, Psidium Guajava Fruit Extract, Euterpe Oleracea Fruit Extract, Ahnfeltiopsis Concinna Extract, Dextran, Hydrolyzed Silk, Lecithin, Glyceryl Polymethacrylate, C12-16 Pareth-9, Trideceth-12, Sodium Lactate, Carbomer, Aspartic Acid, Polysorbate 20, Butylene Glycol, Caprylyl Glycol, PEG-8, C11-15 Pareth-7, Guar Hydroxypropyltrimonium Chloride, Phytosteryl/Octyldodecyl Lauroyl Glutamate, Ectoin, Citrate Buffer, Trimethylsiloxyamodimethicone, Phenoxyethanol, Sodium Hydroxide, Ethylhexylglycerin
Cyclopentasiloxane
Dimethicone
Tetrahexyldecyl Ascorbate
Palmitoyl Tripeptide-5
Ceramide NP
Tocotrienols
Tocopherol
Ubiquinone
Thioctic Acid
Tocopheryl Acetate
Magnesium Ascorbyl Phosphate
Ferulic Acid
Beta-Glucan
Superoxide Dismutase
Epigallocatechin Gallate
Ergothioneine
Glutathione
Xanthophylls
Glycine Soja Seed Extract
Arctostaphylos Uva Ursi Leaf Extract
Lupinus Albus Seed Extract
Curcuma Longa Root
Elaeis Guineensis Oil
Cyclopentasiloxane, Dimethicone, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Ceramide NP, Tocotrienols, Tocopherol, Ubiquinone, Thioctic Acid, Tocopheryl Acetate, Magnesium Ascorbyl Phosphate, Ferulic Acid, Beta-Glucan, Superoxide Dismutase, Epigallocatechin Gallate, Ergothioneine, Glutathione, Xanthophylls, Glycine Soja Seed Extract, Glycerin, Arctostaphylos Uva Ursi Leaf Extract, Lupinus Albus Seed Extract, Curcuma Longa Root, Elaeis Guineensis Oil, Phenoxyethanol
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.