Paula's Choice Pro-Collagen Peptide Plumping Moisturizer Versus Cetaphil Deep Hydration Skin Restoring Water Gel

Paula's Choice Pro-Collagen Peptide Plumping Moisturizer Versus Cetaphil Deep Hydration Skin Restoring Water Gel

This anti-aging moisturizer is formulated around Squalane to soften the look of wrinkles and hydrate skin.

This barrier-repair moisturizer is formulated around Panthenol and Niacinamide to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Dimethicone

Squalane

Glycerin

Pyrus Malus Fruit Extract

Pentylene Glycol

1,2-Hexanediol

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Butylene Glycol

Hydroxyacetophenone

Sodium Acrylates Copolymer

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Gigartina Stellata Extract

Acetyl Sh-Hexapeptide-5 Amide Acetate

Tridecapeptide-1

Oligopeptide-1

Sodium Phytate

Propanediol

Lecithin

Hydroxypropyltrimonium Hyaluronate

Cyanocobalamin

Phenoxyethanol

Water, Dimethicone, Squalane, Glycerin, Pyrus Malus Fruit Extract, Pentylene Glycol, 1,2-Hexanediol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Butylene Glycol, Hydroxyacetophenone, Sodium Acrylates Copolymer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Gigartina Stellata Extract, Acetyl Sh-Hexapeptide-5 Amide Acetate, Tridecapeptide-1, Oligopeptide-1, Sodium Phytate, Propanediol, Lecithin, Hydroxypropyltrimonium Hyaluronate, Cyanocobalamin, Phenoxyethanol

Panthenol

Niacinamide

Octyldodecanol

Sodium Polyacryloyldimethyl Taurate

Xylitylglucoside

Anhydroxylitol

Allantoin

Distarch Phosphate

Xanthan Gum

Caprylyl Glycol

Trehalose

Urea

Xylitol

Hydrolyzed Hyaluronic Acid

Polyglutamic Acid

Serine

Sodium Hydroxide

Pantolactone

Algin

Disodium Phosphate

Glyceryl Polyacrylate

Pullulan

Sodium Hyaluronate

Globularia Alypum Leaf Extract

Citric Acid

Potassium Phosphate

Water, Glycerin, Dimethicone, Propanediol, Panthenol, Niacinamide, Octyldodecanol, Sodium Polyacryloyldimethyl Taurate, Xylitylglucoside, Anhydroxylitol, Allantoin, Distarch Phosphate, Hydroxyacetophenone, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Glycol, 1,2-Hexanediol, Trehalose, Urea, Xylitol, Hydrolyzed Hyaluronic Acid, Polyglutamic Acid, Pentylene Glycol, Serine, Sodium Hydroxide, Pantolactone, Algin, Disodium Phosphate, Glyceryl Polyacrylate, Pullulan, Sodium Hyaluronate, Globularia Alypum Leaf Extract, Citric Acid, Potassium Phosphate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.

As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.

Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.

This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.

You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.

Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.

An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.

So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.

Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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