Paula's Choice Pro Retinaldehyde Dual-Retinoid Treatment Versus Curology Custom Formula Tretinoin 0.01% Clindamycin 1% Azelaic Acid 4%

Paula's Choice Pro Retinaldehyde Dual-Retinoid Treatment Versus Curology Custom Formula Tretinoin 0.01% Clindamycin 1% Azelaic Acid 4%

This anti-aging treatment is formulated around Retinal and Oleyl Adapalenate to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Caprylic/Capric Triglyceride

Simmondsia Chinensis Seed Oil

Dimethicone

Polyglyceryl-2 Stearate

Propanediol

Polyglyceryl-3 Diisostearate

Sodium Stearoyl Glutamate

Retinal

Oleyl Adapalenate

Tocopherol

Tocopheryl Acetate

Saccharomyces Ferment Filtrate

Albatrellus Confluens Extract

Punica Granatum Pericarp Extract

Glyceryl Stearate

Stearyl Alcohol

Hydroxyapatite

Butylene Glycol

Cetyl Glyceryl Ether

Ricinus Communis Seed Oil

Sodium Polyacrylate

Isopropyl Myristate

Hydroxyacetophenone

Caprylhydroxamic Acid

Sodium Phytate

Xanthan Gum

Glycerin

Hydroxystearic Acid

Ceramide AP

1,2-Hexanediol

Sorbitan Oleate

Naringin

Citric Acid

Titanium Dioxide

Water, Caprylic/Capric Triglyceride, Simmondsia Chinensis Seed Oil, Dimethicone, Polyglyceryl-2 Stearate, Propanediol, Polyglyceryl-3 Diisostearate, Sodium Stearoyl Glutamate, Retinal, Oleyl Adapalenate, Tocopherol, Tocopheryl Acetate, Saccharomyces Ferment Filtrate, Albatrellus Confluens Extract, Punica Granatum Pericarp Extract, Glyceryl Stearate, Stearyl Alcohol, Hydroxyapatite, Butylene Glycol, Cetyl Glyceryl Ether, Ricinus Communis Seed Oil, Sodium Polyacrylate, Isopropyl Myristate, Hydroxyacetophenone, Caprylhydroxamic Acid, Sodium Phytate, Xanthan Gum, Glycerin, Hydroxystearic Acid, Ceramide AP, 1,2-Hexanediol, Sorbitan Oleate, Naringin, Citric Acid, Titanium Dioxide

Tretinoin 0.01%

Clindamycin Phosphate 1%

Azelaic Acid 4%

Aloe Barbadensis Leaf Juice

C13-14 Isoparaffin

Laureth-7

Phenoxyethanol

Polyacrylamide

Triethylene Glycol

BHT

Tretinoin 0.01%, Clindamycin Phosphate 1%, Azelaic Acid 4%, Aloe Barbadensis Leaf Juice, C13-14 Isoparaffin, Caprylic/Capric Triglyceride, Water, Laureth-7, Phenoxyethanol, Polyacrylamide, Tocopheryl Acetate, Triethylene Glycol, BHT

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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