Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Paula's Choice Resist Anti-Aging Eye Cream Versus Paula's Choice Omega+ Complex Eye Cream

Paula's Choice Resist Anti-Aging Eye Cream Versus Paula's Choice Omega+ Complex Eye Cream This anti-aging eye moisturizer is formulated around Ascorbyl Glucoside and Palmitoyl Tripeptide-38 to soften the look of wrinkles and fade the look of dark spots. This b

Paula's Choice Resist Anti-Aging Eye Cream Versus Paula's Choice Omega+ Complex Eye Cream

This anti-aging eye moisturizer is formulated around Ascorbyl Glucoside and Palmitoyl Tripeptide-38 to soften the look of wrinkles and fade the look of dark spots.

This barrier-repair eye moisturizer is formulated around Borago Officinalis Seed Oil and Niacinamide to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dimethicone

Sodium PCA

Hydrogenated Polyisobutene

Ascorbyl Glucoside

Sodium Polyacrylate

Hydrogenated Lecithin

Glucosyl Hesperidin

Copper Gluconate

Troxerutin

Disodium Rutinyl Disulfate

Resveratrol

Palmitoyl Tripeptide-38

Caprooyl Tetrapeptide-3

Glycyrrhiza Glabra Root Extract

Phytic Acid

Beta-Glucan

Acetyl Glucosamine

Tocopherol

Allantoin

Adenosine

Dextran

Caprylic/Capric Triglyceride

Sea Whip Extract

Arctostaphylos Uva Ursi Leaf Extract

Salix Alba Bark Extract

Polyacrylate Crosspolymer-6

Hydroxypropyl Cyclodextrin

Xanthan Gum

Cetearyl Alcohol

Maltodextrin

Benzyl Alcohol

Phenoxyethanol

Water, Dimethicone, Sodium PCA, Hydrogenated Polyisobutene, Ascorbyl Glucoside, Sodium Polyacrylate, Hydrogenated Lecithin, Glucosyl Hesperidin, Copper Gluconate, Troxerutin, Disodium Rutinyl Disulfate, Resveratrol, Palmitoyl Tripeptide-38, Caprooyl Tetrapeptide-3, Glycyrrhiza Glabra Root Extract, Phytic Acid, Beta-Glucan, Acetyl Glucosamine, Tocopherol, Allantoin, Adenosine, Dextran, Caprylic/Capric Triglyceride, Sea Whip Extract, Arctostaphylos Uva Ursi Leaf Extract, Salix Alba Bark Extract, Polyacrylate Crosspolymer-6, Hydroxypropyl Cyclodextrin, Xanthan Gum, Cetearyl Alcohol, Maltodextrin, Benzyl Alcohol, Phenoxyethanol

Butylene Glycol

Neopentyl Glycol Diheptanoate

Cetyl Palmitate

Nylon-12

Propanediol

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Propylene Glycol Dibenzoate

Persea Gratissima Oil

Borago Officinalis Seed Oil

Sodium Stearoyl Glutamate

Squalane

Niacinamide

Salvia Hispanica Seed Oil

Linum Usitatissimum Seed Oil

Limnanthes Alba Seed Oil

Olea Europaea Fruit Oil

Passiflora Edulis Seed Oil

Ceramide EOP

Ceramide NP

Ceramide AP

Sodium Hyaluronate

Cholesterol

Morus Alba Root Extract

Arctostaphylos Uva-Ursi Leaf Extract

Linoleic Acid

Linolenic Acid

Serine

Alanine

Proline

Arginine

Threonine

Phytosphingosine

Phytosterols

Glycine

Oleic Acid

Glutamic Acid

Lysine Hcl

Lecithin

Sodium Lactate

Hydrogenated Olive Oil

Euterpe Oleracea Sterols

Olea Europaea Oil Unsaponifiables

Scutellaria Baicalensis Root Extract

Anastatica Hierochuntica Extract

Glycerin

PCA

Betaine

Pullulan

Carbomer

Sclerotium Gum

Sodium Citrate

Citric Acid

Ascorbyl Palmitate

Tocopheryl Acetate

Silica

Sorbitan Oleate

Sodium Lauroyl Lactylate

Ethylhexylglycerin

Chlorphenesin

Water, Caprylic/Capric Triglyceride, Butylene Glycol, Neopentyl Glycol Diheptanoate, Cetyl Palmitate, Nylon-12, Propanediol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Propylene Glycol Dibenzoate, Persea Gratissima Oil, Borago Officinalis Seed Oil, Sodium Stearoyl Glutamate, Squalane, Niacinamide, Salvia Hispanica Seed Oil, Linum Usitatissimum Seed Oil, Limnanthes Alba Seed Oil, Olea Europaea Fruit Oil, Passiflora Edulis Seed Oil, Ceramide EOP, Ceramide NP, Ceramide AP, Sodium Hyaluronate, Cholesterol, Morus Alba Root Extract, Arctostaphylos Uva-Ursi Leaf Extract, Glycyrrhiza Glabra Root Extract, Linoleic Acid, Linolenic Acid, Serine, Alanine, Proline, Arginine, Threonine, Phytosphingosine, Phytosterols, Sodium PCA, Glycine, Oleic Acid, Glutamic Acid, Lysine Hcl, Lecithin, Adenosine, Sodium Lactate, Hydrogenated Olive Oil, Euterpe Oleracea Sterols, Olea Europaea Oil Unsaponifiables, Phytic Acid, Scutellaria Baicalensis Root Extract, Anastatica Hierochuntica Extract, Glycerin, PCA, Betaine, Pullulan, Carbomer, Sclerotium Gum, Sodium Citrate, Citric Acid, Ascorbyl Palmitate, Tocopheryl Acetate, Silica, Sorbitan Oleate, Xanthan Gum, Sodium Lauroyl Lactylate, Phenoxyethanol, Ethylhexylglycerin, Chlorphenesin

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Phytic Acid is a gentle AHA and antioxidant. AHAs are chemical exfoliants that help remove dead skin cells. Phytic Acid has a slight and mild exfoliating effect.

The chemical makeup makes it classified as an AHA, much like lactic acid.

In some cases, it is a chelating agent. Chelating agents help prevent metals from binding to water, helping to stabilize the ingredients in a product.

An interesting fact about phytic acid is that it is considered an antinutrient. People do not have the enzyme needed to properly breakdown and digest phytic acid. When ingested, phytic acid binds to minerals and prevents them from being absorbed.

Read more about some other popular AHA's here:

Sodium PCA (the salt of PCA) is one of the most well-established humectants in skincare.

Why is it so special? Your skin already makes it naturally; it's a natural component of your skin's Natural Moisturizing Factor (NMF), or the mix of water-binding compounds inside your skin cells that keeps things soft and hydrated.

As a cosmetic ingredient, it grabs water and holds it in the upper layers of skin to smooth roughness and ease dehydration.

There's some clinical support for the NMF approach with a study showing that a cream built to mimic the skin's NMF significantly boosted hydration.

Safety-wise, this ingredient non-irritating, non-comedogenic, and non-phototoxic in testing, with minimal skin absorption.

It also works really well with other hydrators like glycerin or hyaluronic acid, and typical usage is somewhere between 0.2-4%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Side-by-side

  1. 01Salicylic Acid 2%
  2. 02Water
  3. 03Methylpropanediol
  4. 04Butylene Glycol
  5. 05Polysorbate 20
  6. 06Camellia Oleifera Leaf Extract
  7. 07Sodium Hydroxide
  8. 08Tetrasodium EDTA
  9. 09Phenoxyethanol
  10. 10Salicylic Acid 2%, Water, Methylpropanediol, Butylene Glycol, Polysorbate 20, Camellia Oleifera Leaf Extract, Sodium Hydroxide, Tetrasodium EDTA, Phenoxyethanol
  11. 11Salicylic Acid
  12. 12Hydroxyacetophenone
  13. 13Ethylhexylglycerin
  14. 14Water, Methylpropanediol, Butylene Glycol, Salicylic Acid, Sodium Hydroxide, Polysorbate 20, Tetrasodium EDTA, Camellia Oleifera Leaf Extract, Phenoxyethanol, Hydroxyacetophenone, Ethylhexylglycerin
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side