Paula's Choice Resist Anti-Aging Eye Gel Versus Paula's Choice Resist Anti-Aging Eye Cream

Paula's Choice Resist Anti-Aging Eye Gel Versus Paula's Choice Resist Anti-Aging Eye Cream

This anti-aging eye moisturizer is formulated around Palmitoyl Tripeptide-38 and Palmitoyl Tripeptide-5 to soften the look of wrinkles and refine skin texture.

This anti-aging eye moisturizer is formulated around Ascorbyl Glucoside and Palmitoyl Tripeptide-38 to soften the look of wrinkles and fade the look of dark spots.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Cyclopentasiloxane

Butylene Glycol

Pentylene Glycol

Tapioca Starch

Methyl Gluceth-20 Benzoate

Glycerin

Dimethicone

Cyclohexasiloxane

Polysilicone-11

Palmitoyl Tripeptide-38

Caprooyl Tetrapeptide-3

Palmitoyl Tripeptide-5

Niacinamide

Phospholipids

Hyaluronic Acid

Sodium Hyaluronate

Vitis Vinifera Seed Extract

Panthenol

Salix Alba Extract

Camellia Sinensis Leaf Extract

Adenosine

Glycyrrhiza Glabra Root Extract

Pisum Sativum Extract

Polyacrylate Crosspolymer-6

Dunaliella Salina Extract

Hydroxypropyl Cyclodextrin

Dextran

Polysorbate 20

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Disodium EDTA

Phenoxyethanol

Water, Cyclopentasiloxane, Butylene Glycol, Pentylene Glycol, Tapioca Starch, Methyl Gluceth-20 Benzoate, Glycerin, Dimethicone, Cyclohexasiloxane, Polysilicone-11, Palmitoyl Tripeptide-38, Caprooyl Tetrapeptide-3, Palmitoyl Tripeptide-5, Niacinamide, Phospholipids, Hyaluronic Acid, Sodium Hyaluronate, Vitis Vinifera Seed Extract, Panthenol, Salix Alba Extract, Camellia Sinensis Leaf Extract, Adenosine, Glycyrrhiza Glabra Root Extract, Pisum Sativum Extract, Polyacrylate Crosspolymer-6, Dunaliella Salina Extract, Hydroxypropyl Cyclodextrin, Dextran, Polysorbate 20, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Disodium EDTA, Phenoxyethanol

Sodium PCA

Hydrogenated Polyisobutene

Ascorbyl Glucoside

Sodium Polyacrylate

Hydrogenated Lecithin

Glucosyl Hesperidin

Copper Gluconate

Troxerutin

Disodium Rutinyl Disulfate

Resveratrol

Phytic Acid

Beta-Glucan

Acetyl Glucosamine

Tocopherol

Allantoin

Caprylic/Capric Triglyceride

Sea Whip Extract

Arctostaphylos Uva Ursi Leaf Extract

Salix Alba Bark Extract

Xanthan Gum

Cetearyl Alcohol

Maltodextrin

Benzyl Alcohol

Water, Dimethicone, Sodium PCA, Hydrogenated Polyisobutene, Ascorbyl Glucoside, Sodium Polyacrylate, Hydrogenated Lecithin, Glucosyl Hesperidin, Copper Gluconate, Troxerutin, Disodium Rutinyl Disulfate, Resveratrol, Palmitoyl Tripeptide-38, Caprooyl Tetrapeptide-3, Glycyrrhiza Glabra Root Extract, Phytic Acid, Beta-Glucan, Acetyl Glucosamine, Tocopherol, Allantoin, Adenosine, Dextran, Caprylic/Capric Triglyceride, Sea Whip Extract, Arctostaphylos Uva Ursi Leaf Extract, Salix Alba Bark Extract, Polyacrylate Crosspolymer-6, Hydroxypropyl Cyclodextrin, Xanthan Gum, Cetearyl Alcohol, Maltodextrin, Benzyl Alcohol, Phenoxyethanol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Caprooyl Tetrapeptide-3 is a peptide.

Dextran is a sugar (polysaccharide) with skin hydrating properties.

Fun fact: Louis Pasteur first discovered this ingredient as a microbial product in wine.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

This ingredient is used in skincare as a delivery system.

It works by "encapsulating" active ingredients with its unique ring shape that is water-loving on the outside and oil-loving on the inside. This improves the stability and absorption of the product into the skin.

According to a manufacturer, it also offer some moisturizing effects.

This synthetic, signal peptide has unique skin conditioning properties in that is a matrikine-mimetic compound.

First of all, Palmitoyl Tripeptide-38 is a signal peptide; signal peptides tell the body to create more collagen.

What is a matrikine-mimetic compound?

This peptide has the ability to mimic matrikines in skin. Our skin created matrikines by breaking down matrix proteins into peptides.

Matrikines play a role in:

Though further research is needed, this ingredient seems pretty promising. In one study, women over the age of 40 with visible photoaging used a vitamin C serum with this ingredient for 56 days (15% ascorbid acid, 5 ppm palmitoyl tripeptide‐38). The results found improvement in skin roughness and skin tone.

This peptide is also part of the famous Matrixyl synthe’6, a blend of ingredients that also includes glycerin, water, and hydroxypropyl cyclodextrin.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Polyacrylate Crosspolymer-6 is a texture enhancer and pH adjuster.

It is be used to thicken water-based products and create a gel-texture with a velvet feel.

One manufacturer claims this ingredient to have a pH range of 2-8 and to be biodegradable.

This ingredient is also known as Sepimax Zen.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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