Skin science article
Paula's Choice Resist Super Antioxidant Serum Versus Paula's Choice Earth Sourced Power Berry Serum
Paula's Choice Resist Super Antioxidant Serum Versus Paula's Choice Earth Sourced Power Berry Serum This anti-aging serum is formulated around Tetrahexyldecyl Ascorbate and Palmitoyl Tripeptide-5 to soften the look of wrinkles and brighten dull-looking skin. T
Paula's Choice Resist Super Antioxidant Serum Versus Paula's Choice Earth Sourced Power Berry Serum
This anti-aging serum is formulated around Tetrahexyldecyl Ascorbate and Palmitoyl Tripeptide-5 to soften the look of wrinkles and brighten dull-looking skin.
This calming serum is formulated around Glycyrrhiza Glabra Root Extract and Tetrahexyldecyl Ascorbate to calm redness and brighten dull-looking skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Cyclopentasiloxane
Dimethicone
Tetrahexyldecyl Ascorbate
Palmitoyl Tripeptide-5
Ceramide NP
Tocotrienols
Tocopherol
Ubiquinone
Thioctic Acid
Tocopheryl Acetate
Magnesium Ascorbyl Phosphate
Ferulic Acid
Beta-Glucan
Superoxide Dismutase
Epigallocatechin Gallate
Ergothioneine
Glutathione
Xanthophylls
Glycine Soja Seed Extract
Glycerin
Arctostaphylos Uva Ursi Leaf Extract
Lupinus Albus Seed Extract
Curcuma Longa Root
Elaeis Guineensis Oil
Phenoxyethanol
Cyclopentasiloxane, Dimethicone, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Ceramide NP, Tocotrienols, Tocopherol, Ubiquinone, Thioctic Acid, Tocopheryl Acetate, Magnesium Ascorbyl Phosphate, Ferulic Acid, Beta-Glucan, Superoxide Dismutase, Epigallocatechin Gallate, Ergothioneine, Glutathione, Xanthophylls, Glycine Soja Seed Extract, Glycerin, Arctostaphylos Uva Ursi Leaf Extract, Lupinus Albus Seed Extract, Curcuma Longa Root, Elaeis Guineensis Oil, Phenoxyethanol
Water
Coco-Caprylate
Butylene Glycol
Propanediol
Glyceryl Stearate
Emblica Officinalis Fruit Extract
Euterpe Oleracea Fruit Extract
Vaccinium Macrocarpon Fruit Extract
Vaccinium Myrtillus Fruit Extract
Rubus Idaeus Fruit Extract
Sambucus Nigra Fruit Extract
Malpighia Emarginata Fruit Extract
Hippophae Rhamnoides Fruit Extract
Schisandra Chinensis Fruit Extract
Rubus Chamaemorus Fruit Extract
Lycium Barbarum Fruit Extract
Plinia Cauliflora Fruit Extract
Fragaria Vesca Fruit Extract
Melia Azadirachta Flower Extract
Melia Azadirachta Leaf Extract
Myrciaria Dubia Fruit Extract
Vitis Vinifera Seed Extract
Glycyrrhiza Glabra Root Extract
Squalane
Acetyl Tetrapeptide-9
Acetyl Tetrapeptide-11
Prunus Domestica Seed Oil
Sesamum Indicum Seed Oil
Leuconostoc/Radish Root Ferment Filtrate
Corallina Officinalis Extract
Coccinia Indica Fruit Extract
Brassica Campestris Seed Oil
Xanthan Gum
Mannitol
Potassium Sorbate
Sodium Benzoate
Ethylhexylglycerin
Water, Glycerin, Coco-Caprylate, Butylene Glycol, Propanediol, Glyceryl Stearate, Emblica Officinalis Fruit Extract, Euterpe Oleracea Fruit Extract, Vaccinium Macrocarpon Fruit Extract, Vaccinium Myrtillus Fruit Extract, Rubus Idaeus Fruit Extract, Sambucus Nigra Fruit Extract, Malpighia Emarginata Fruit Extract, Hippophae Rhamnoides Fruit Extract, Schisandra Chinensis Fruit Extract, Rubus Chamaemorus Fruit Extract, Lycium Barbarum Fruit Extract, Plinia Cauliflora Fruit Extract, Fragaria Vesca Fruit Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Myrciaria Dubia Fruit Extract, Vitis Vinifera Seed Extract, Glycyrrhiza Glabra Root Extract, Squalane, Tetrahexyldecyl Ascorbate, Tocopherol, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-11, Prunus Domestica Seed Oil, Sesamum Indicum Seed Oil, Leuconostoc/Radish Root Ferment Filtrate, Corallina Officinalis Extract, Coccinia Indica Fruit Extract, Brassica Campestris Seed Oil, Xanthan Gum, Mannitol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol, Ethylhexylglycerin
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Tetrahexyldecyl Ascorbate (THD) is a stable and oil-soluble form of Vitamin C.
THD is special in that it has the ability to travel deeper into skin than traditional ascorbic acid while maintaining the same skin benefits (double win!).
Because it’s oil-soluble, THD dives deep into your skin’s fatty layers (think ceramides and cholesterol) to fight off the kind of free radicals that mess with your skin barrier. This makes it a great pair with water-based vitamin C (ascorbic acid) that mainly works on the surface.
Even at just 0.1%, THD is already showing great antioxidant activity. When used up to 2%, it helps keep your skin happy and calm, especially when it’s stressed from pollution or sun.
Want to fade dark spots or tackle hyperpigmentation? You’ll want 5% or more. Pairing it with brightening buddies like niacinamide or licorice root gives even better results. One study even used 30% THD with other brighteners and saw real results on stubborn discoloration, even in melasma-prone skin.
A note on THD: It’s has a slightly silky, oily texture and usually shows up colorless or pale yellow (though the exact shade can vary by supplier).
While you can sneak it into water-based formulas, it really shines when paired with silicones or oils, which help your skin soak it up better.
THD is pretty stable, but it’s still vulnerable to degradation like ascorbic acid. Too much light or heat (above 113°F / 45°C) can break it down over time. Go for dark and opaque packaging that keeps it safe and shady!
Read more about other types of Vitamin C:
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.