Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Paula's Choice Resist Super Antioxidant Serum Versus The INKEY List 15% Vitamin C And EGF Serum

Paula's Choice Resist Super Antioxidant Serum Versus The INKEY List 15% Vitamin C And EGF Serum This anti-aging serum is formulated around Tetrahexyldecyl Ascorbate and Palmitoyl Tripeptide-5 to soften the look of wrinkles and brighten dull-looking skin. This

Paula's Choice Resist Super Antioxidant Serum Versus The INKEY List 15% Vitamin C And EGF Serum

This anti-aging serum is formulated around Tetrahexyldecyl Ascorbate and Palmitoyl Tripeptide-5 to soften the look of wrinkles and brighten dull-looking skin.

This brightening serum is formulated around Ascorbyl Glucoside to brighten dull-looking skin and fade the look of dark spots.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Cyclopentasiloxane

Dimethicone

Tetrahexyldecyl Ascorbate

Palmitoyl Tripeptide-5

Ceramide NP

Tocotrienols

Tocopherol

Ubiquinone

Thioctic Acid

Tocopheryl Acetate

Magnesium Ascorbyl Phosphate

Ferulic Acid

Beta-Glucan

Superoxide Dismutase

Epigallocatechin Gallate

Ergothioneine

Glutathione

Xanthophylls

Glycine Soja Seed Extract

Glycerin

Arctostaphylos Uva Ursi Leaf Extract

Lupinus Albus Seed Extract

Curcuma Longa Root

Elaeis Guineensis Oil

Phenoxyethanol

Cyclopentasiloxane, Dimethicone, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Ceramide NP, Tocotrienols, Tocopherol, Ubiquinone, Thioctic Acid, Tocopheryl Acetate, Magnesium Ascorbyl Phosphate, Ferulic Acid, Beta-Glucan, Superoxide Dismutase, Epigallocatechin Gallate, Ergothioneine, Glutathione, Xanthophylls, Glycine Soja Seed Extract, Glycerin, Arctostaphylos Uva Ursi Leaf Extract, Lupinus Albus Seed Extract, Curcuma Longa Root, Elaeis Guineensis Oil, Phenoxyethanol

Water

Ascorbyl Glucoside

Sodium Hydroxide

PEG-40 Hydrogenated Castor Oil

Benzyl Alcohol

Butylene Glycol

Xanthan Gum

Ethylhexylglycerin

Sodium Metabisulfite

Dehydroacetic Acid

Phytic Acid

Oligopeptide-1

Water, Ascorbyl Glucoside, Sodium Hydroxide, PEG-40 Hydrogenated Castor Oil, Phenoxyethanol, Benzyl Alcohol, Butylene Glycol, Xanthan Gum, Ethylhexylglycerin, Sodium Metabisulfite, Dehydroacetic Acid, Phytic Acid, Oligopeptide-1

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Also known as Avobenzone, this ingredient is an oil-soluble used to absorb the full spectrum of UVA rays (peak 357 nm).
  4. 04It's one of the most effective UVA filters available but has a major caveat of photostability: avobenzone is susceptible to photodegradation.
  5. 05This means it can lose efficacy when exposed to sunlight without the help of a stabilizing agent.
  6. 06Studies show antioxidants (like vitamin E or vitamin C) and some UV filters (like octocrylene and Tinosorb S) can meaningfully improve its stability in a formulation.
  7. 07The maximum allowable concentration according to regulation is 3% in the US + Canada, and 5% in the EU, Australia, China, Korea, and ASEAN countries.
  8. 08It has a well-support safety profile: a comprehensive 2025 review found minimal toxicity with no evidence of carcinogenicity.
  9. 09Overall, avobenzone is a safe and regulated ingredient used in sunscreen for over 40 years.
  10. 10Ethylhexyl Salicylate (also called Octisalate or Octyl Salicylate) is an oil-soluble organic UV filter that's been used in sunscreen since the 1950's.
  11. 11It absorbs UVB light in the 280-320 nm range with a peak absorbance around 306 nm.
  12. 12You'll often see it paired with other UV filters to boost overall SPF because octisalate is a fairly week filter on its own.
  13. 13The reason you'll see it so often is because it can help solubilize and stabilize the trickier filters like oxybenzone and avobenzone.
  14. 14Unlike these filters, octisalate has pretty good photostability and doesn't create skin-damaging free radicals when exposed to sunlight.
  15. 15The fatty-alcohol part of the molecule also gives it a light, emollient feel so it doubles as a nice texture enhancer.
  16. 16Usage levels vary around the world:
  17. 17Safety-wise, this ingredient has a pretty reassuring track record. The EU's Scientific Committee on Consumer Products (SCCP) found very low skin penetration in human skin tests and negative results for irritation, phototoxicity, and photoallergy.
  18. 18The real-world allergy risk is pretty low too; a 2012 European study of 1,031 people recorded only 2 reactions to it (a rate of 0.19%).
  19. 19You might have seen scary headlines about sunscreen getting into your blood.
  20. 20In 2019, the FDA found that several chemical filters can absorb through the skin and show up in the bloodstream at small but measurable levels.
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side