Skin science article
Prequel Half & Half Peptides & Ceramides Fluid Moisturizer Versus Dieux Skin Air Angel Peptide Plumping Gel Cream
Prequel Half & Half Peptides & Ceramides Fluid Moisturizer Versus Dieux Skin Air Angel Peptide Plumping Gel Cream This barrier-repair moisturizer is formulated around Ceramide NP and Hexapeptide-11 to strengthen the skin barrier and soften the look of wrinkles
Prequel Half & Half Peptides & Ceramides Fluid Moisturizer Versus Dieux Skin Air Angel Peptide Plumping Gel Cream
This barrier-repair moisturizer is formulated around Ceramide NP and Hexapeptide-11 to strengthen the skin barrier and soften the look of wrinkles.
This barrier-repair moisturizer is formulated around Palmitoyl Hexapeptide-12 and Squalane to strengthen the skin barrier and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Propanediol
Isopropyl Myristate
Ethylhexyl Olivate
Squalane
Hydrolyzed Rice Protein
Ceramide NP
Ceramide As
Ceramide Ns
Ceramide EOP
Ceramide AP
Hexapeptide-11
Matrixyl 3000
Polyglyceryl-10 Stearate
Triolein
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Glyceryl Oleate
Undecane
Hydroxyacetophenone
Glyceryl Dioleate
Caprylyl Glycol
Xanthan Gum
Tridecane
Betaine
Sodium Stearoyl Glutamate
Citric Acid
Sodium Phytate
Sodium PCA
Sodium Hydroxide
Sodium Lactate
PCA
Sodium Benzoate
Serine
Alanine
Palmitic Acid
Glycine
Hydrogenated Lecithin
Ethylhexyl Palmitate
Butylene Glycol
Phenoxyethanol
Ethylhexylglycerin
Glutamic Acid
Lysine Hcl
Threonine
Arginine
Proline
Tocopherol
Carbomer
Polysorbate 20
Water, Glycerin, Propanediol, Isopropyl Myristate, Ethylhexyl Olivate, Squalane, Hydrolyzed Rice Protein, Ceramide NP, Ceramide As, Ceramide Ns, Ceramide EOP, Ceramide AP, Hexapeptide-11, Matrixyl 3000, Polyglyceryl-10 Stearate, Triolein, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Glyceryl Oleate, Undecane, Hydroxyacetophenone, Glyceryl Dioleate, Caprylyl Glycol, Xanthan Gum, Tridecane, Betaine, Sodium Stearoyl Glutamate, Citric Acid, Sodium Phytate, Sodium PCA, Sodium Hydroxide, Sodium Lactate, PCA, Sodium Benzoate, Serine, Alanine, Palmitic Acid, Glycine, Hydrogenated Lecithin, Ethylhexyl Palmitate, Butylene Glycol, Phenoxyethanol, Ethylhexylglycerin, Glutamic Acid, Lysine Hcl, Threonine, Arginine, Proline, Tocopherol, Carbomer, Polysorbate 20
Dimethicone
Dimethicone Crosspolymer
C12-15 Alkyl Benzoate
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Imperata Cylindrica Root Extract
Caprylic/Capric Triglyceride
Methylpropanediol
Cetyl Alcohol
Meadowfoam Estolide
Dipalmitoyl Hydroxyproline
Tribehenin
Urea
Collagen Amino Acids
Haematococcus Pluvialis Extract
Trehalose
Linoleic Acid
Phytosterols
Phospholipids
Polysorbate 60
Sorbitan Isostearate
Ceramide Ng
Hexylene Glycol
PEG-10 Phytosterol
Polyquaternium-51
Triacetin
Sodium Hyaluronate
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Palmitoyl Hexapeptide-12
Lactic Acid
Water, Glycerin, Dimethicone, Dimethicone Crosspolymer, C12-15 Alkyl Benzoate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Imperata Cylindrica Root Extract, Caprylic/Capric Triglyceride, Methylpropanediol, Squalane, Cetyl Alcohol, Meadowfoam Estolide, Dipalmitoyl Hydroxyproline, Tribehenin, Sodium PCA, Urea, Carbomer, Phenoxyethanol, Caprylyl Glycol, Collagen Amino Acids, Propanediol, Haematococcus Pluvialis Extract, Trehalose, Linoleic Acid, Phytosterols, Phospholipids, Palmitic Acid, Polysorbate 60, Sorbitan Isostearate, Ceramide Ng, Hexylene Glycol, PEG-10 Phytosterol, Polyquaternium-51, Triacetin, Sodium Hyaluronate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Palmitoyl Hexapeptide-12, Sodium Hydroxide, Lactic Acid
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Palmitic Acid is a fatty acid naturally found in our skin and in many plant and animal sources.
In cosmetics, it is usually derived from palm oil. It serves many purposes in skincare, acting as a cleanser, emollient, and emulsifier.
Interestingly, topically applied Palmitic Acid can be elongated into longer chain fatty acids and ceramides. A 2019 study found low levels of Palmitic Acid lead to slower development of cells, suggesting it plays a role in keeping your skin's renewal process on track.
The CIR (Cosmetic Ingredient Review) panel determined it safe as used in cosmetics at concentrations up to 13%. It is non-irritating and non-sensitizing in clinical studies.
The culprit behind fungal acne, the Malassezia yeast, feeds on fatty acids with carbon chain lengths between C11-C24. Palmitic Acid, at C16, falls right into that sweet spot.
In vitro studies have shown that Palmitic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.
It's worth noting that what feeds yeast in a lab doesn't necessarily feed it on your face since formulation and your skin's chemistry play a bigger role.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Sodium PCA (the salt of PCA) is one of the most well-established humectants in skincare.
Why is it so special? Your skin already makes it naturally; it's a natural component of your skin's Natural Moisturizing Factor (NMF), or the mix of water-binding compounds inside your skin cells that keeps things soft and hydrated.
As a cosmetic ingredient, it grabs water and holds it in the upper layers of skin to smooth roughness and ease dehydration.
There's some clinical support for the NMF approach with a study showing that a cream built to mimic the skin's NMF significantly boosted hydration.
Safety-wise, this ingredient non-irritating, non-comedogenic, and non-phototoxic in testing, with minimal skin absorption.
It also works really well with other hydrators like glycerin or hyaluronic acid, and typical usage is somewhere between 0.2-4%.
Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!