Skin science article
Puca – Pure & Care Retinol Serum Vitamin A Versus The INKEY List Retinol Serum
Puca – Pure & Care Retinol Serum Vitamin A Versus The INKEY List Retinol Serum This anti-aging serum is formulated around Retinol and Adenosine to soften the look of wrinkles and fade the look of dark spots. This anti-aging serum is formulated around Retinyl A
Puca – Pure & Care Retinol Serum Vitamin A Versus The INKEY List Retinol Serum
This anti-aging serum is formulated around Retinol and Adenosine to soften the look of wrinkles and fade the look of dark spots.
This anti-aging serum is formulated around Retinyl Acetate and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and refine skin texture.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Propanediol
Propylene Glycol
Glycerin
Corn Gluten Amino Acids
Sodium Polyglutamate
Hydroxypropyl Cyclodextrin
PEG-40 Hydrogenated Castor Oil
Sodium Hyaluronate
Retinol
Oligopeptide-1
Oligopeptide-2
Oligopeptide-5
Hyaluronic Acid
Collagen
Adenosine
Aloe Barbadensis Leaf Extract
Yeast Ferment Extract
Silk Extract
Avena Sativa Kernel Extract
Mentha Arvensis Leaf Extract
Pelargonium Graveolens Extract
Portulaca Oleracea Extract
Chrysanthemum Indicum Flower Extract
Sophora Flavescens Root Extract
Beta-Glucan
Butylene Glycol
Hexylene Glycol
Xanthan Gum
1,2-Hexanediol
Sodium Benzoate
Ethylhexylglycerin
Potassium Sorbate
Sodium Hydroxide
Hydroxyacetophenone
Phenoxyethanol
Water, Propanediol, Propylene Glycol, Glycerin, Corn Gluten Amino Acids, Sodium Polyglutamate, Hydroxypropyl Cyclodextrin, PEG-40 Hydrogenated Castor Oil, Sodium Hyaluronate, Retinol, Oligopeptide-1, Oligopeptide-2, Oligopeptide-5, Hyaluronic Acid, Collagen, Adenosine, Aloe Barbadensis Leaf Extract, Yeast Ferment Extract, Silk Extract, Avena Sativa Kernel Extract, Mentha Arvensis Leaf Extract, Pelargonium Graveolens Extract, Portulaca Oleracea Extract, Chrysanthemum Indicum Flower Extract, Sophora Flavescens Root Extract, Beta-Glucan, Butylene Glycol, Hexylene Glycol, Xanthan Gum, 1,2-Hexanediol, Sodium Benzoate, Ethylhexylglycerin, Potassium Sorbate, Sodium Hydroxide, Hydroxyacetophenone, Phenoxyethanol
Dicaprylyl Carbonate
Retinyl Acetate
Dimethicone
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Caprylyl Glycol
Phospholipids
Squalane
Glycine Soja Oil
Carbomer
Polysorbate 60
Tocopheryl Acetate
Glycolipids
Sodium Phytate
Sorbitan Isostearate
Glycine Soja Sterols
Tetrahexyldecyl Ascorbate
Leuconostoc/Radish Root Ferment Filtrate
Sodium Lactate
Tocopherol
Polysorbate 20
Palmitoyl Tetrapeptide-7
Palmitoyl Tripeptide-1
Water, Glycerin, Butylene Glycol, Propanediol, Dicaprylyl Carbonate, Retinyl Acetate, Dimethicone, Phenoxyethanol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Caprylyl Glycol, Phospholipids, Squalane, Glycine Soja Oil, Carbomer, Polysorbate 60, Tocopheryl Acetate, Glycolipids, Sodium Hydroxide, Sodium Phytate, Sorbitan Isostearate, Glycine Soja Sterols, Tetrahexyldecyl Ascorbate, Leuconostoc/Radish Root Ferment Filtrate, Hyaluronic Acid, Sodium Lactate, Tocopherol, Polysorbate 20, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.
Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.
The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
This is why the best HA serums blend the two sizes together so you get the best of both worlds.
The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.
A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.
These are some other common types of Hyaluronic Acid:
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!