Puca – Pure & Care Serum Argireline Versus Skin Deva 20% Argireline + Matrixyl 3000 + Hyaluronic Acid Serum

Puca – Pure & Care Serum Argireline Versus Skin Deva 20% Argireline + Matrixyl 3000 + Hyaluronic Acid Serum

This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Sodium Hyaluronate to soften the look of wrinkles and hydrate skin.

This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Matrixyl 3000 to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Propanediol

Glycerin

Corn Gluten Amino Acids

Glyceryl Glucoside

Saccharide Isomerate

Acetyl Hexapeptide-8

Sodium Hyaluronate

Aloe Barbadensis Leaf Extract

Yeast Ferment Extract

Panthenol

Avena Sativa Kernel Extract

Mentha Arvensis Leaf Extract

Pelargonium Graveolens Extract

Sophora Flavescens Root Extract

Chrysanthemum Indicum Flower Extract

Portulaca Oleracea Extract

Caprylyl Glycol

Hexylene Glycol

Butylene Glycol

Xanthan Gum

Citric Acid

Sodium Citrate

1,2-Hexanediol

Phenoxyethanol

Potassium Sorbate

Sodium Benzoate

Sodium Hydroxide

Ethylhexylglycerin

Hydroxyacetophenone

Water, Propanediol, Glycerin, Corn Gluten Amino Acids, Glyceryl Glucoside, Saccharide Isomerate, Acetyl Hexapeptide-8, Sodium Hyaluronate, Aloe Barbadensis Leaf Extract, Yeast Ferment Extract, Panthenol, Avena Sativa Kernel Extract, Mentha Arvensis Leaf Extract, Pelargonium Graveolens Extract, Sophora Flavescens Root Extract, Chrysanthemum Indicum Flower Extract, Portulaca Oleracea Extract, Caprylyl Glycol, Hexylene Glycol, Butylene Glycol, Xanthan Gum, Citric Acid, Sodium Citrate, 1,2-Hexanediol, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Sodium Hydroxide, Ethylhexylglycerin, Hydroxyacetophenone

Acetyl Hexapeptide-8 20%

Matrixyl 3000

Hyaluronic Acid

Benzyl Alcohol

Dehydroacetic Acid

Water, Acetyl Hexapeptide-8 20%, Matrixyl 3000, Aloe Barbadensis Leaf Extract, Glycerin, Hyaluronic Acid, Benzyl Alcohol, Dehydroacetic Acid

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Aloe Barbadensis Leaf Extract is a botanical extract pulled from the leaves of aloe vera and one of the most studied plant ingredients in cosmetics.

The inner leaf gel it comes from is mostly water (~99-99.5%) and the remaining fraction is made up of pretty good stuff: polysaccharides, vitamins, phenolics, and enzymes.

Its headline job is hydration.

The star polysaccharide in aloe, acemannan, is a humectant that retains moisture and helps reduce trans-epidermal water loss.

Aloe also has real soothing credentials; it contains anti-inflammatory compounds like bradykinase and C-glucosyl chromone that help calm irritation and redness.

On the repair side, lab work shows that acemannan wakes up your skin's repair cells (fibroblasts), prompting them to multiply and speed up healing.

There's some human data for cosmetic benefit too: a cream containing 10% Aloe Barbadensis leaf extract improved skin hydration and elasticity in a real-use study.

Safety-wise, this ingredient is well-regarded with just one rare downside; there have been some case reports of acute eczema, contact urticaria, and dermatitis in people who applied aloe-derived ingredients topically. Those with a known aloe or Liliaceae sensitivity should patch test.

Typical use levels range widely, from under 1% up to 90%+ depending on the format and the effect you are after.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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