Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

REFY Lip Gloss Versus rhode Peptide Lip Treatment

REFY Lip Gloss Versus rhode Peptide Lip Treatment This anti-aging lip moisturizer is formulated around Butyrospermum Parkii Butter and Palmitoyl Tripeptide-1 to soften the look of wrinkles and hydrate lips. What's inside Key Ingredients Benefits Concerns Ingre

REFY Lip Gloss Versus rhode Peptide Lip Treatment

This anti-aging lip moisturizer is formulated around Butyrospermum Parkii Butter and Palmitoyl Tripeptide-1 to soften the look of wrinkles and hydrate lips.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Polyisobutene

Tridecyl Trimellitate

Octyldodecanol

Cera Microcristallina

Silica Dimethyl Silylate

Simmondsia Chinensis Seed Oil

Tocopheryl Acetate

Phenoxyethanol

Butyrospermum Parkii Butter

Caprylyl Glycol

Limnanthes Alba Seed Oil

Glyceryl Behenate

Sodium Hyaluronate

CI 15850

Iron Oxides

CI 77891

Polyisobutene, Tridecyl Trimellitate, Octyldodecanol, Cera Microcristallina, Silica Dimethyl Silylate, Simmondsia Chinensis Seed Oil, Tocopheryl Acetate, Phenoxyethanol, Butyrospermum Parkii Butter, Caprylyl Glycol, Limnanthes Alba Seed Oil, Glyceryl Behenate, Sodium Hyaluronate, CI 15850, Iron Oxides, CI 77891

Hydrogenated Polyisobutene

Diisostearyl Malate

Polybutene

Microcrystalline Wax

Synthetic Beeswax

Synthetic Wax

Hydrogenated Poly(C6-14 Olefin)

Polyglyceryl-2 Triisostearate

Dimer Dilinoleyl Dimer Dilinoleate

Glyceryl Behenate/Eicosadioate

Triethyl Citrate

Tocopherol

Tetrahexyldecyl Ascorbate

Palmitoyl Tripeptide-1

Orbignya Oleifera Seed Oil

Theobroma Grandiflorum Seed Butter

Lactic Acid

Tribehenin

Stevioside

Ethylhexyl Palmitate

Sorbitan Isostearate

Synthetic Fluorphlogopite

Disteardimonium Hectorite

O-Cymen-5-Ol

Hydrogenated Polyisobutene, Diisostearyl Malate, Butyrospermum Parkii Butter, Polybutene, Microcrystalline Wax, Synthetic Beeswax, Synthetic Wax, Octyldodecanol, Hydrogenated Poly(C6-14 Olefin), Polyglyceryl-2 Triisostearate, Dimer Dilinoleyl Dimer Dilinoleate, Glyceryl Behenate/Eicosadioate, Triethyl Citrate, Tocopherol, Tocopheryl Acetate, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-1, Orbignya Oleifera Seed Oil, Theobroma Grandiflorum Seed Butter, Lactic Acid, Tribehenin, Stevioside, Ethylhexyl Palmitate, Sorbitan Isostearate, Synthetic Fluorphlogopite, Disteardimonium Hectorite, O-Cymen-5-Ol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Octyldodecanol is a fatty alcohol sourced from plant oils like coconut or palm (or made synthetically).

It is:

You'll likely see this in many BHA products because this is the go-to solvent for salicylic acid.

This ingredient is typically used at levels between 2-20%.

Regarding fungal acne: In 2019, this ingredient was tested against multiple Malassezia species (the yeast that causes fungal acne) and showed no growth.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Ethylhexyl Palmitate, also known as octyl palmitate, is created from 2-ethylhexyl alcohol and palmitic acid.
  4. 04In cosmetics, it plays many roles:
  5. 05One thing worth noting: a controlled study found this ingredient applied under occlusion to acne-prone subjects increased microcomedones. Just keep in mind this was under occlusive conditions and don't reflect how most products are used day-to-day.
  6. 06For most people, this is a well-tolerated and lightweight ingredient.
  7. 07This ingredient may not be fungal acne safe because it is an ester of palmitic acid, a C16 fatty acid that falls within the C11-24 range that Malassezia can metabolize.
  8. 08Hydrogenated Polyisobutene is a synthetic polymer. Polymers are compounds with high molecular weight. Hydrogenated Polyisobutene is an emollient and texture enhancer.
  9. 09In one study, Hydrogenated Polyisobutene showed better skin hydration levels than Caprylic/Capric Triglyceride. As an emollient, it helps keep your skin soft and hydrated by trapping moisture in.
  10. 10Hydrogenated Polyisobutene is often used as a mineral oil replacement.
  11. 11Octyldodecanol is a fatty alcohol sourced from plant oils like coconut or palm (or made synthetically).
  12. 12It is:
  13. 13You'll likely see this in many BHA products because this is the go-to solvent for salicylic acid.
  14. 14This ingredient is typically used at levels between 2-20%.
  15. 15Regarding fungal acne: In 2019, this ingredient was tested against multiple Malassezia species (the yeast that causes fungal acne) and showed no growth.
  16. 16Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid.
  17. 17That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference.
  18. 18Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.
  19. 19In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than…
  20. 20Human clinical data is promising, but modest:
Source · skinsort.com
02

Product index

Related product references

Product

rhode Peptide Lip Treatment

rhode Peptide Lip Treatment rhode Peptide Lip Treatment ingredients explained: Hydrogenated Polyisobutene, Diisostearyl Malate, Butyrospermum Parkii (Shea) Butter, Polybutene, Microcrystall…

Source: incidecoder.comView reference →
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Comparison edit

Read side by side