Rejuran Advanced Anti-Aging Retinol + C-PDRN Serum Versus One Thing Peptide Retinal Serum

Rejuran Advanced Anti-Aging Retinol + C-PDRN Serum Versus One Thing Peptide Retinal Serum

This anti-aging serum is formulated around Retinol and Palmitoyl Tripeptide-38 to soften the look of wrinkles and refine skin texture.

This anti-aging serum is formulated around Niacinamide and Palmitoyl Tripeptide-5 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Aloe Barbadensis Leaf Juice

Rubus Villosus Fruit Extract

Vaccinium Angustifolium Fruit Extract

Morus Nigra Leaf Extract

Cucumis Sativus Fruit Extract

Daucus Carota Sativa Root

Calendula Officinalis Flower

Caprylic/Capric Triglyceride

Citrus Aurantium Dulcis Peel Extract

Borago Officinalis Seed Oil

Panthenol

Glycerin

Argania Spinosa Kernel Oil

Sodium Ascorbyl Phosphate

Allantoin

Hydrolyzed DNA

Adenosine

Retinol

Palmitoyl Tripeptide-38

Xanthan Gum

Hydroxyethylcellulose

Carbomer

Dimethicone

1,2-Hexanediol

Ethylhexylglycerin

Aloe Barbadensis Leaf Juice, Rubus Villosus Fruit Extract, Vaccinium Angustifolium Fruit Extract, Morus Nigra Leaf Extract, Cucumis Sativus Fruit Extract, Daucus Carota Sativa Root, Calendula Officinalis Flower, Caprylic/Capric Triglyceride, Citrus Aurantium Dulcis Peel Extract, Borago Officinalis Seed Oil, Panthenol, Glycerin, Argania Spinosa Kernel Oil, Sodium Ascorbyl Phosphate, Allantoin, Hydrolyzed DNA, Adenosine, Retinol, Palmitoyl Tripeptide-38, Xanthan Gum, Hydroxyethylcellulose, Carbomer, Dimethicone, 1,2-Hexanediol, Ethylhexylglycerin

Water

Butylene Glycol

Niacinamide

Dipropylene Glycol

Cetyl Ethylhexanoate

Propanediol

Vinyldimethicone

Glyceryl Polymethacrylate

Betaine

C14-22 Alcohols

Cetearyl Olivate

Glyceryl Stearate

Hydroxyacetophenone

Propylene Glycol

Sorbitan Olivate

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

C12-20 Alkyl Glucoside

Polyacrylate Crosspolymer-6

Hydrolyzed Gardenia Florida Extract

Hydrolyzed Malt Extract

Hydrolyzed Viola Tricolor Extract

Sodium Polyacrylate

Dextrin

Disodium EDTA

Sodium Polyacryloyldimethyl Taurate

Gardenia Florida Fruit Extract

Hyaluronic Acid

Hydrolyzed Hyaluronic Acid

Sodium Hyaluronate

Hydrogenated Polydecene

Hydrogenated Lecithin

Polyglyceryl-10 Oleate

Sodium Lactate

Trideceth-10

Palmitoyl Tripeptide-5

Polysorbate 20

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Copper Tripeptide-1

Palmitoyl Pentapeptide-4

Acetyl Hexapeptide-8

Macadamia Ternifolia Seed Oil

Phosphatidylcholine

Cholesterol

Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate

Aluminum/Magnesium Hydroxide Stearate

Brassica Campestris Sterols

Retinal

Potassium Cetyl Phosphate

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Water, Butylene Glycol, Niacinamide, Caprylic/Capric Triglyceride, Dipropylene Glycol, Cetyl Ethylhexanoate, Propanediol, Vinyldimethicone, Glycerin, Glyceryl Polymethacrylate, 1,2-Hexanediol, Betaine, C14-22 Alcohols, Cetearyl Olivate, Glyceryl Stearate, Hydroxyacetophenone, Propylene Glycol, Sorbitan Olivate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, C12-20 Alkyl Glucoside, Ethylhexylglycerin, Polyacrylate Crosspolymer-6, Adenosine, Hydrolyzed Gardenia Florida Extract, Hydrolyzed Malt Extract, Hydrolyzed Viola Tricolor Extract, Sodium Polyacrylate, Dextrin, Disodium EDTA, Sodium Polyacryloyldimethyl Taurate, Gardenia Florida Fruit Extract, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Hydrogenated Polydecene, Carbomer, Hydrogenated Lecithin, Polyglyceryl-10 Oleate, Sodium Lactate, Trideceth-10, Palmitoyl Tripeptide-5, Polysorbate 20, Sodium Ascorbyl Phosphate, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Acetyl Hexapeptide-8, Macadamia Ternifolia Seed Oil, Phosphatidylcholine, Cholesterol, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Aluminum/Magnesium Hydroxide Stearate, Brassica Campestris Sterols, Retinal, Potassium Cetyl Phosphate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Sodium Ascorbyl Phosphate (SAP) is a water-soluble form of Vitamin C. It is the salt of ascorbic acid.

This ingredient is commonly used in skincare because it's more formulation-stable while still offering the same benefits as pure ascorbic acid. Ascorbic acid is notorious for breaking down when exposed to sunlight and oxygen whereas SAP has been shown to be more stable.

Studies show SAP has anti-acne and antioxidant benefits. One study found 5% of SAP lotion to be an effective ingredient for treating acne vulgaris. This is because research shows that SAP may help control acne by reducing acne-causing bacteria and slowing the oxidation of skin oils caused by UV exposure.

In addition to acne, vitamin C is important for skin structure. Lab studies suggest SAP may support collagen production in skin cells, making it a great ingredient in anti-aging routines.

Vitamin C has many benefits: it helps reduce redness, improve skin texture, fade the appearance of dark spots, and brighten the skin.

Read more about other types of Vitamin C:

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