Some By Mi Retinol Intense Advanced Triple Action Eye Cream Versus MediCube PDRN Pink Peptide Eye Cream

Some By Mi Retinol Intense Advanced Triple Action Eye Cream Versus MediCube PDRN Pink Peptide Eye Cream

This anti-aging eye moisturizer is formulated around Niacinamide and Retinol to soften the look of wrinkles and fade the look of dark spots.

This anti-aging eye moisturizer is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Caprylic/Capric Triglyceride

Dimethicone

Polysorbate 60

Niacinamide

Methylpropanediol

Cetyl Alcohol

Polymethylsilsesquioxane

Centella Asiatica Extract

Dioscorea Japonica Root Extract

Piper Methysticum Leaf/Root/Stem Extract

Melaleuca Alternifolia Leaf Extract

Panax Ginseng Berry Extract

Artemisia Capillaris Extract

Ganoderma Lucidum Stem Extract

Chlorella Vulgaris Extract

Glycine Soja Seed Extract

Nymphaea Alba Flower Extract

Elaeis Guineensis Oil

Hydrogenated Lecithin

Sodium Hyaluronate

1,2-Hexanediol

Dimethicone/Vinyl Dimethicone Crosspolymer

Panthenol

BHT

Cyclopentasiloxane

Steareth-21

PEG-10 Dimethicone/Vinyl Dimethicone Crosspolymer

Polyacrylamide

Steareth-2

Isohexadecane

Carbomer

Hydroxyacetophenone

C13-14 Isoparaffin

Tromethamine

Palmitic Acid

Polyquaternium-51

Stearic Acid

Polysorbate 20

Retinol 0.1%

Ethylhexylglycerin

Glyceryl Caprylate

Tocopheryl Acetate

Polyglyceryl-10 Myristate

PEG-30 Dipolyhydroxystearate

Hydroxyethylcellulose

Glycosyl Trehalose

Beta-Glucan

Glyceryl Polymethacrylate

Laureth-7

Butylene Glycol

Disodium EDTA

Hydrogenated Starch Hydrolysate

Adenosine

Raffinose

Dipotassium Glycyrrhizate

Lecithin

Tocopherol

Pentylene Glycol

BHA

Myristic Acid

Tranexamic Acid

Propanediol

Dipropylene Glycol

Disodium Phosphate

Caprylyl Glycol

Collagen

Madecassic Acid

Biosaccharide Gum-1

Asiaticoside

Sodium Palmitoyl Proline

Leuconostoc/Radish Root Ferment Filtrate

Asiatic Acid

Glutathione

Retinal

Madecassoside

Sodium Phosphate

Ferulic Acid

Acetyl Hexapeptide-8

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Tetrahydropiperine

Phloretin

Arginine

Parfum

Water, Glycerin, Caprylic/Capric Triglyceride, Dimethicone, Polysorbate 60, Niacinamide, Methylpropanediol, Cetyl Alcohol, Polymethylsilsesquioxane, Centella Asiatica Extract, Dioscorea Japonica Root Extract, Piper Methysticum Leaf/Root/Stem Extract, Melaleuca Alternifolia Leaf Extract, Panax Ginseng Berry Extract, Artemisia Capillaris Extract, Ganoderma Lucidum Stem Extract, Chlorella Vulgaris Extract, Glycine Soja Seed Extract, Nymphaea Alba Flower Extract, Elaeis Guineensis Oil, Hydrogenated Lecithin, Sodium Hyaluronate, 1,2-Hexanediol, Dimethicone/Vinyl Dimethicone Crosspolymer, Panthenol, BHT, Cyclopentasiloxane, Steareth-21, PEG-10 Dimethicone/Vinyl Dimethicone Crosspolymer, Polyacrylamide, Steareth-2, Isohexadecane, Carbomer, Hydroxyacetophenone, C13-14 Isoparaffin, Tromethamine, Palmitic Acid, Polyquaternium-51, Stearic Acid, Polysorbate 20, Retinol 0.1%, Ethylhexylglycerin, Glyceryl Caprylate, Tocopheryl Acetate, Polyglyceryl-10 Myristate, PEG-30 Dipolyhydroxystearate, Hydroxyethylcellulose, Glycosyl Trehalose, Beta-Glucan, Glyceryl Polymethacrylate, Laureth-7, Butylene Glycol, Disodium EDTA, Hydrogenated Starch Hydrolysate, Adenosine, Raffinose, Dipotassium Glycyrrhizate, Lecithin, Tocopherol, Pentylene Glycol, BHA, Myristic Acid, Tranexamic Acid, Propanediol, Dipropylene Glycol, Disodium Phosphate, Caprylyl Glycol, Collagen, Madecassic Acid, Biosaccharide Gum-1, Asiaticoside, Sodium Palmitoyl Proline, Leuconostoc/Radish Root Ferment Filtrate, Asiatic Acid, Glutathione, Retinal, Madecassoside, Sodium Phosphate, Ferulic Acid, Acetyl Hexapeptide-8, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Tetrahydropiperine, Phloretin, Arginine, Parfum

Pentaerythrityl Tetraethylhexanoate

Cetearyl Alcohol

Glycereth-26

Butylene Glycol Dicaprylate/Dicaprate

Bis-Behenyl/Isostearyl/Phytosteryl Dimer Dilinoleyl Dimer Dilinoleate

Cetearyl Olivate

Sorbitan Olivate

Propylene Glycol Dibenzoate

Pullulan

Glyceryl Stearate

Vinyldimethicone

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Sodium DNA

Polyisobutene

Melia Azadirachta Leaf Extract

Melia Azadirachta Flower Extract

Curcuma Longa Root Extract

Sorbitan Isostearate

Sorbitan Oleate

Caprylyl/Capryl Glucoside

Fragaria Chiloensis Fruit Extract

Hedera Helix Leaf/Stem Extract

Cyanocobalamin

Citrus Nobilis Peel Extract

Retinol

Ocimum Sanctum Leaf Extract

Lespedeza Capitata Leaf/Stem Extract

Corallina Officinalis Extract

Caffeine

Coffea Arabica Seed Extract

Hydrolyzed Extensin

Hydrolyzed Hyaluronic Acid

Copper Tripeptide-1

Sodium Acetylated Hyaluronate

Palmitoyl Pentapeptide-4

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Water, Glycerin, Dipropylene Glycol, Niacinamide, Caprylic/Capric Triglyceride, Pentaerythrityl Tetraethylhexanoate, Cetearyl Alcohol, Glycereth-26, Butylene Glycol Dicaprylate/Dicaprate, Bis-Behenyl/Isostearyl/Phytosteryl Dimer Dilinoleyl Dimer Dilinoleate, Cetearyl Olivate, Sorbitan Olivate, Propylene Glycol Dibenzoate, Pullulan, 1,2-Hexanediol, Glyceryl Stearate, Vinyldimethicone, Hydroxyacetophenone, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydrogenated Lecithin, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium DNA, Polyisobutene, Butylene Glycol, Ethylhexylglycerin, Propanediol, Melia Azadirachta Leaf Extract, Adenosine, Melia Azadirachta Flower Extract, Curcuma Longa Root Extract, Sorbitan Isostearate, Sorbitan Oleate, Caprylyl/Capryl Glucoside, Fragaria Chiloensis Fruit Extract, Hedera Helix Leaf/Stem Extract, Cyanocobalamin, Citrus Nobilis Peel Extract, Retinol, Ocimum Sanctum Leaf Extract, Lespedeza Capitata Leaf/Stem Extract, Corallina Officinalis Extract, Sodium Hyaluronate, Caffeine, Coffea Arabica Seed Extract, Hydrolyzed Extensin, Hydrolyzed Hyaluronic Acid, Copper Tripeptide-1, Sodium Acetylated Hyaluronate, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Hydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.

As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.

Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.

This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.

You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.

Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.

An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.

So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.

Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Retinol is one of the most studied anti-aging ingredients in skincare (and for good reason!).

It's a form of vitamin A that your skin converts into Retinoic Acid, the active molecule that actually does the work in your cells.

That conversion happens in two steps: your skin first turns Retinol into Retinaldehyde (also called Retinal), then turns Retinaldehyde into Retinoic Acid.

Retinol is converted to biologically active retinoic acid via retinaldehyde by dehydrogenases in a two-step oxidation process.

Each step is a little "upgrade" toward the active form which is part of why Retinol is gentler than prescription Retinoic Acid; your skin does the work gradually. This also explains where Retinol sits in the retinoid family.

Here is the retinoid family ranked roughly by strength: Retinyl Esters (like Retinyl Palmitate) < Retinol < Retinaldehyde < Retinoic Acid.

Retinoid activity increases in that order, while tolerance runs in reverse; retinyl esters are the gentlest and retinoic acid the most irritating.

The more conversion steps an ingredient needs, the gentler (and slower) it tends to be, so Retinol lands in a nice middle spot. It's more effective than the esters, gentler than prescription options.

Once it becomes Retinoic Acid, it binds to receptors inside your cells' nuclei (called RARs and RXRs). These receptor pairs bind to specific DNA motifs called retinoic acid response elements and act like switches that turn certain genes on or off.

In practice, this means a few things happen in a formula. It:

That last two are worth a closer look.

A study that tested Retinol directly (not just prescription Retinoic Acid) found that four weeks of retinol thickened the epidermis and switched on the genes for Collagen I and Collagen III, with more procollagen I and III showing up in the skin. And after twelve weeks, facial wrinkles were visibly reduced.

Retinoids more broadly stimulate the skin's synthesis of hyaluronan and other glycosaminoglycans, part of what gives skin a plumper, more hydrated look over time.

So even the gentler OTC form is doing real structural work (not just sitting on the surface).

It's also worth knowing Retinol isn't only a wrinkle ingredient; it can help with uneven tone, dark spots, rough texture, and the look of pores as well because it speeds up turnover and influences pigment.

The research backs this up as well.

A pooled analysis of six clinical studies found that 0.1% stabilized retinol improved all signs of photoaging versus vehicle as early as week 4 and through 12 weeks, with only a few mild cases of irritation.

Another study comparing concentrations found that 0.3% and 1% Retinol were similarly effective at remodeling photodamaged skin, but 0.3% caused fewer adverse reactions when used daily (a useful reminder that more isn't always better).

Retinol is about tenfold less potent than Retinoic Acid. This is why it works as a gentler, non-prescription option that builds results over time.

Typical concentrations range from 0.1-1%, with 0.1% to 0.3% being a well-supported sweet spot for visible benefits with good tolerability.

One quirk worth mentioning: Retinol is famously unstable.

It's highly sensitive to light and oxygen, and UV exposure breaks it down into a range of degradation products.

Real-world testing bears this out, with retinoid content in some products dropping anywhere from 0% to 80% after six months at room temperature, and even more at higher temperatures.

This is why good formulations lean on opaque, air-tight packaging (think tubes and pumps, not clear jars) and often "encapsulate" the Retinol to shield it.

Signs of oxidation include your product turning yellow or smelling "off". Keeping it somewhere cool and dark, and using it up within a few months of opening helps it stay effective.

The most common side effects are mild and temporary: usually some dryness, redness, or light peeling as your skin adjusts. These tend to settle with consistent and lower-frequency use.

Like all retinoids, Retinol works best with nightly use, a good moisturizer, and daytime sunscreen.

The "ramp up" method works well: start with Retinol once a week to give your skin time to adjust, which keeps irritation low. Slowly add more nights until you reach your goal frequency once your skin feels comfortable.

Retinoids also make your skin more sensitive to the sun in the first few weeks, so wear sunscreen every morning and protect your skin from direct sun while you build up tolerance.

One safety note: topical Retinoids aren't recommended during pregnancy or breastfeeding. Systemic absorption from creams is low but because high oral vitamin A is a known teratogen and topical safety data are limited, most clinicians recommend stopping retinoids when pregnant or trying to conceive.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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