Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Some By Mi Retinol Intense Advanced Triple Action Eye Cream Versus The INKEY List Retinol Serum

Some By Mi Retinol Intense Advanced Triple Action Eye Cream Versus The INKEY List Retinol Serum This anti-aging eye moisturizer is formulated around Niacinamide and Retinol to soften the look of wrinkles and fade the look of dark spots. This anti-aging serum i

Some By Mi Retinol Intense Advanced Triple Action Eye Cream Versus The INKEY List Retinol Serum

This anti-aging eye moisturizer is formulated around Niacinamide and Retinol to soften the look of wrinkles and fade the look of dark spots.

This anti-aging serum is formulated around Retinyl Acetate and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Caprylic/Capric Triglyceride

Dimethicone

Polysorbate 60

Niacinamide

Methylpropanediol

Cetyl Alcohol

Polymethylsilsesquioxane

Centella Asiatica Extract

Dioscorea Japonica Root Extract

Piper Methysticum Leaf/Root/Stem Extract

Melaleuca Alternifolia Leaf Extract

Panax Ginseng Berry Extract

Artemisia Capillaris Extract

Ganoderma Lucidum Stem Extract

Chlorella Vulgaris Extract

Glycine Soja Seed Extract

Nymphaea Alba Flower Extract

Elaeis Guineensis Oil

Hydrogenated Lecithin

Sodium Hyaluronate

1,2-Hexanediol

Dimethicone/Vinyl Dimethicone Crosspolymer

Panthenol

BHT

Cyclopentasiloxane

Steareth-21

PEG-10 Dimethicone/Vinyl Dimethicone Crosspolymer

Polyacrylamide

Steareth-2

Isohexadecane

Carbomer

Hydroxyacetophenone

C13-14 Isoparaffin

Tromethamine

Palmitic Acid

Polyquaternium-51

Stearic Acid

Polysorbate 20

Retinol 0.1%

Ethylhexylglycerin

Glyceryl Caprylate

Tocopheryl Acetate

Polyglyceryl-10 Myristate

PEG-30 Dipolyhydroxystearate

Hydroxyethylcellulose

Glycosyl Trehalose

Beta-Glucan

Glyceryl Polymethacrylate

Laureth-7

Butylene Glycol

Disodium EDTA

Hydrogenated Starch Hydrolysate

Adenosine

Raffinose

Dipotassium Glycyrrhizate

Lecithin

Tocopherol

Pentylene Glycol

BHA

Myristic Acid

Tranexamic Acid

Propanediol

Dipropylene Glycol

Disodium Phosphate

Caprylyl Glycol

Collagen

Madecassic Acid

Biosaccharide Gum-1

Asiaticoside

Sodium Palmitoyl Proline

Leuconostoc/Radish Root Ferment Filtrate

Asiatic Acid

Glutathione

Retinal

Madecassoside

Sodium Phosphate

Ferulic Acid

Acetyl Hexapeptide-8

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Tetrahydropiperine

Phloretin

Arginine

Parfum

Water, Glycerin, Caprylic/Capric Triglyceride, Dimethicone, Polysorbate 60, Niacinamide, Methylpropanediol, Cetyl Alcohol, Polymethylsilsesquioxane, Centella Asiatica Extract, Dioscorea Japonica Root Extract, Piper Methysticum Leaf/Root/Stem Extract, Melaleuca Alternifolia Leaf Extract, Panax Ginseng Berry Extract, Artemisia Capillaris Extract, Ganoderma Lucidum Stem Extract, Chlorella Vulgaris Extract, Glycine Soja Seed Extract, Nymphaea Alba Flower Extract, Elaeis Guineensis Oil, Hydrogenated Lecithin, Sodium Hyaluronate, 1,2-Hexanediol, Dimethicone/Vinyl Dimethicone Crosspolymer, Panthenol, BHT, Cyclopentasiloxane, Steareth-21, PEG-10 Dimethicone/Vinyl Dimethicone Crosspolymer, Polyacrylamide, Steareth-2, Isohexadecane, Carbomer, Hydroxyacetophenone, C13-14 Isoparaffin, Tromethamine, Palmitic Acid, Polyquaternium-51, Stearic Acid, Polysorbate 20, Retinol 0.1%, Ethylhexylglycerin, Glyceryl Caprylate, Tocopheryl Acetate, Polyglyceryl-10 Myristate, PEG-30 Dipolyhydroxystearate, Hydroxyethylcellulose, Glycosyl Trehalose, Beta-Glucan, Glyceryl Polymethacrylate, Laureth-7, Butylene Glycol, Disodium EDTA, Hydrogenated Starch Hydrolysate, Adenosine, Raffinose, Dipotassium Glycyrrhizate, Lecithin, Tocopherol, Pentylene Glycol, BHA, Myristic Acid, Tranexamic Acid, Propanediol, Dipropylene Glycol, Disodium Phosphate, Caprylyl Glycol, Collagen, Madecassic Acid, Biosaccharide Gum-1, Asiaticoside, Sodium Palmitoyl Proline, Leuconostoc/Radish Root Ferment Filtrate, Asiatic Acid, Glutathione, Retinal, Madecassoside, Sodium Phosphate, Ferulic Acid, Acetyl Hexapeptide-8, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Tetrahydropiperine, Phloretin, Arginine, Parfum

Dicaprylyl Carbonate

Retinyl Acetate

Phenoxyethanol

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Phospholipids

Squalane

Glycine Soja Oil

Glycolipids

Sodium Hydroxide

Sodium Phytate

Sorbitan Isostearate

Glycine Soja Sterols

Tetrahexyldecyl Ascorbate

Hyaluronic Acid

Sodium Lactate

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Water, Glycerin, Butylene Glycol, Propanediol, Dicaprylyl Carbonate, Retinyl Acetate, Dimethicone, Phenoxyethanol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Caprylyl Glycol, Phospholipids, Squalane, Glycine Soja Oil, Carbomer, Polysorbate 60, Tocopheryl Acetate, Glycolipids, Sodium Hydroxide, Sodium Phytate, Sorbitan Isostearate, Glycine Soja Sterols, Tetrahexyldecyl Ascorbate, Leuconostoc/Radish Root Ferment Filtrate, Hyaluronic Acid, Sodium Lactate, Tocopherol, Polysorbate 20, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Leuconostoc/Radish Root Ferment Filtrate is a natural preservative. It comes from fermenting radish roots with a bacteria called leuconostoc. The trade name for this ingredient is Leucidal.

Leuconostoc comes from lactic acid.

This ingredient has antimicrobial properties and helps prevent the growth of bacteria in a product.

Leuconostoc is used to make the traditional Korean side-dish, kimchi. It is also used to make sourdough bread (both incredibly yummy foods).

Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.

It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.

The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.

Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).

True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.

Because it is derived from lauric acid, it may not be fungal acne safe.

Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.

Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.

In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.

Polysorbates are commonly used in medicine and foods.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Side-by-side

  1. 01Water
  2. 02Squalane
  3. 03Glycerin
  4. 04Propanediol
  5. 05Plukenetia Volubilis Seed Oil
  6. 06Dicaprylyl Carbonate
  7. 07Bakuchiol
  8. 08Phenoxyethanol
  9. 09Sodium Caproyl Prolinate
  10. 10Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
  11. 11Carbomer
  12. 12Sodium Hydroxide
  13. 13Ethylhexylglycerin
  14. 14Sodium Stearoyl Glutamate
  15. 15Polysorbate 60
  16. 16Phytic Acid
  17. 17Glyceryl Polyacrylate
  18. 18Sorbitan Isostearate
  19. 19Tocopherol
  20. 20Water, Squalane, Glycerin, Propanediol, Plukenetia Volubilis Seed Oil, Dicaprylyl Carbonate, Bakuchiol, Phenoxyethanol, Sodium Caproyl Prolinate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Carbomer, Sodium Hydroxide, Ethylhexyl…
Source · skinsort.com
02

Product index

Related product references

Product

The Inkey List Glycolic Acid Toner

The Inkey List Glycolic Acid Toner The Inkey List Glycolic Acid Toner ingredients explained: Aqua (Water), Glycolic Acid, Propanediol, Hamamelis Virginiana (Witch Hazel) Water, Sodium Hydro…

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side