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Skin science article

Stay Well Vegan Collagen Serum Versus Stay Well Triple Hyaluronic Acid Serum

Stay Well Vegan Collagen Serum Versus Stay Well Triple Hyaluronic Acid Serum This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Copper Tripeptide-1 to soften the look of wrinkles and refine skin texture. This hydrating serum is formulated arou

Stay Well Vegan Collagen Serum Versus Stay Well Triple Hyaluronic Acid Serum

This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Copper Tripeptide-1 to soften the look of wrinkles and refine skin texture.

This hydrating serum is formulated around Sodium Hyaluronate and Hydrolyzed Hyaluronic Acid to hydrate skin and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Wheat Amino Acids

1,2-Hexanediol

Natto Gum

Propanediol

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Polyglyceryl-10 Laurate

Ethylhexylglycerin

Dipotassium Glycyrrhizate

Xanthan Gum

Disodium EDTA

Carbomer

Acetyl Hexapeptide-8

Oligopeptide-29

Oligopeptide-32

Copper Tripeptide-1

Palmitoyl Pentapeptide-4

Tromethamine

Parfum

Bakuchiol

Water, Glycerin, Butylene Glycol, Wheat Amino Acids, 1,2-Hexanediol, Natto Gum, Propanediol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Polyglyceryl-10 Laurate, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Xanthan Gum, Disodium EDTA, Carbomer, Acetyl Hexapeptide-8, Oligopeptide-29, Oligopeptide-32, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Tromethamine, Parfum, Bakuchiol

Isopentyldiol

Betaine

Sodium Hyaluronate

Xylitylglucoside

Anhydroxylitol

Hydrolyzed Hyaluronic Acid

Xylitol

Gossypium Herbaceum Seed Extract

Glucose

Sodium Acetylated Hyaluronate

Water, Glycerin, Isopentyldiol, Butylene Glycol, Betaine, 1,2-Hexanediol, Carbomer, Propanediol, Tromethamine, Polyglyceryl-10 Laurate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Ethylhexylglycerin, Sodium Hyaluronate, Disodium EDTA, Parfum, Xylitylglucoside, Anhydroxylitol, Hydrolyzed Hyaluronic Acid, Xylitol, Gossypium Herbaceum Seed Extract, Glucose, Sodium Acetylated Hyaluronate

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Ammonium Acryloyldimethyltaurate/Vp Copolymer is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.

Think of it as a supportive ingredient that helps your gel-creams feel silky, "cloud cream-like", and spread evenly without being greasy.

The Cosmetic Ingredient Review (CIR) Expert Panel evaluated it (along with 22 other acryloyldimethyltaurate polymers) and concluded it's:

Due to its large molecular size, it sits on the surface of skin rather than penetrating it.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Polyglyceryl-10 Laurate is a cleansing agent and emulsifier.

It rounds up dirt, oil, and grime, so they can be rinsed off easily as a cleanser.

On the emulsifier side, it keeps your formula smooth and well-mixed by playing peacekeeper for ingredients that don't naturally get along (like oil and water).

Because it has a C12 (lauric acid) fatty acid chain, this ingredient can potentially feed the Malassezia yeast that causes fungal acne. The Malassezia yeast prefers esters with C11-C24 fatty acids.

This ingredient is an ester of lauric acid and Polyglycerin-10.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Handmade Heroes The Ultimate Snow Shroom Hyaluronic Acid SerumIngredients explained

  1. 01Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
  2. 02It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
  3. 03Expand to read more
  4. 04Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
  5. 05One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
  6. 06Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved.
  7. 07It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula.
  8. 08A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product…
  9. 09A natural moisturizer that’s also in our skin
  10. 10A super common, safe, effective and cheap molecule used for more than 50 years
  11. 11Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  12. 12Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
  13. 13High-glycerin moisturizers are awesome for treating severely dry skin
  14. 14We don't have description for this ingredient yet.
  15. 15It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated sub…
  16. 16As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule a…
  17. 17In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost t…
  18. 18What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
  19. 19If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
  20. 20It's a super small, chemically chopped up version of sodium hyaluronate. Its trade name is miniHA, and its molecular weight is 10 kDa. This counts as really tiny given that "normal" HA has a molecular weight of 0.5-2 million Da.
Source · incidecoder.com
02

Product index

Related product references

Product

Dr. Brenner Hyaluronic Acid Serum

Dr. Brenner Hyaluronic Acid Serum Dr. Brenner Hyaluronic Acid Serum ingredients explained: Water, Calcium Pantothenate (Vitamin B5), Sodium Hyaluronate (Hyaluronic Acid), Phenoxyethanol Sho…

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side

04

Ask the journal

Related questions

01What Skin Types Should Use Hyaluronic Acid?

“Hyaluronic acid is particularly helpful for those experiencing dry skin, and for those desiring a plumping effect,” explains Dr. King. But, if you have an oily skin type, don’t discredit hyaluronic acid from your routine just yet. Despite the excess sebum that you may experience, it’s important to keep your skin hydrated so that it doesn’t overcompensate and produce even more oil as a result. Besides your skin type, you should also look at the condition of your skin to decide if it’s time to begin using hyaluronic acid. “If your skin is starting to look dull, flaky and you’re seeing more pronounced fine lines and wrinkles, that’s a pretty good indication that it’s time to add this ingredient to your routine,” adds O’Conner.

Source · www.skincare.com
02How to Apply Face Serums

Skincare rules can get confusing, but when it comes to application the general rule of thumb is to pay attention to the product’s consistency. “Apply the lightest, thinnest product first and the heaviest, and more dense products last, since thinner products can’t penetrate thicker products,”says Dr. Lewis. After cleansing the face and following up with a toner, let the skin dry before using a serum. You can layer different serums on top of each other or opt for a product that has a precise mix of multiple hero ingredients, such as hyaluronic acid and vitamin C.

Source · www.skincare.com