Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Stay Well Vegan Collagen Serum Versus Stay Well Triple Hyaluronic Acid Watery Gel Cream

Stay Well Vegan Collagen Serum Versus Stay Well Triple Hyaluronic Acid Watery Gel Cream This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Copper Tripeptide-1 to soften the look of wrinkles and refine skin texture. This barrier-repair moisturi

Stay Well Vegan Collagen Serum Versus Stay Well Triple Hyaluronic Acid Watery Gel Cream

This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Copper Tripeptide-1 to soften the look of wrinkles and refine skin texture.

This barrier-repair moisturizer is formulated around Sodium Hyaluronate and Hydrolyzed Hyaluronic Acid to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Wheat Amino Acids

1,2-Hexanediol

Natto Gum

Propanediol

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Polyglyceryl-10 Laurate

Ethylhexylglycerin

Dipotassium Glycyrrhizate

Xanthan Gum

Disodium EDTA

Carbomer

Acetyl Hexapeptide-8

Oligopeptide-29

Oligopeptide-32

Copper Tripeptide-1

Palmitoyl Pentapeptide-4

Tromethamine

Parfum

Bakuchiol

Water, Glycerin, Butylene Glycol, Wheat Amino Acids, 1,2-Hexanediol, Natto Gum, Propanediol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Polyglyceryl-10 Laurate, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Xanthan Gum, Disodium EDTA, Carbomer, Acetyl Hexapeptide-8, Oligopeptide-29, Oligopeptide-32, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Tromethamine, Parfum, Bakuchiol

Sodium Hyaluronate

Hydrolyzed Hyaluronic Acid

Sodium Acetylated Hyaluronate

Cetearyl Olivate

Sorbitan Olivate

Helianthus Annuus Seed Oil

Zea Mays Starch

Mannitol

Microcrystalline Cellulose

Tocopheryl Acetate

CI 77007

Hydrogenated Lecithin

Caprylyl Glycol

Persea Gratissima Oil

Betaine

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Xylitylglucoside

Anhydroxylitol

Xylitol

Glucose

Gossypium Herbaceum Seed Extract

Water, Butylene Glycol, 1,2-Hexanediol, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Cetearyl Olivate, Sorbitan Olivate, Helianthus Annuus Seed Oil, Zea Mays Starch, Mannitol, Microcrystalline Cellulose, Tocopheryl Acetate, CI 77007, Hydrogenated Lecithin, Caprylyl Glycol, Ethylhexylglycerin, Disodium EDTA, Persea Gratissima Oil, Betaine, Tromethamine, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Parfum, Xylitylglucoside, Anhydroxylitol, Xylitol, Glucose, Gossypium Herbaceum Seed Extract

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

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Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  4. 04Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  5. 05Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  6. 06Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  7. 07Topically, glycerin does several things at once:
  8. 08Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  9. 09Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  10. 10This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  11. 11Just know very high concentrations (>40%) can feel tacky in low humidity.
  12. 12Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  13. 13Hydrolyzed Collagen is Collagen (usually sourced from fish, bovine, or porcine byproducts) that's been broken down into smaller peptides. This makes it water-soluble and easy to blend into formulations.
  14. 14In a formula, it works mainly as a skin-conditioning and moisturizing agent.
  15. 15The small peptides and amino acids (including Natural Moisturizing Factor components like Hydroxyproline, Serine, and Aspartic Acid) help the surface of the skin hold onto water, feel softer, and look temporarily plumper.
  16. 16This ingredient also has mild film-forming and antioxidant properties with research showing the antioxidant effect is stronger the lower the molecular weight of the peptides.
  17. 17It's worth being realistic here:
  18. 18Topically applied Hydrolyzed Collagen conditions the upper layers of skin rather than rebuilding the structural collagen deep in your dermis (the wrinkle-and-firmness benefits people associate with Collagen mostly come from oral supplements in studi…
  19. 19However, recent lab and skin-model work on Hydrolyzed Fish Collagen has shown promising effects on cell viability and wound healing when used as an active.
  20. 20Typical concentrations range from 0.2-2%, but the percentage can go much higher in rinse-off or hair products (sometimes even above 50%).
Source · skinsort.com
02

Product index

Related product references

Product

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XYCOS Pink Collagen Serum

XYCOS Pink Collagen Serum XYCOS Pink Collagen Serum ingredients explained: Water (Aqua), Butylene Glycol, Squalane, Cetyl Ethylhexanoate, Caprylic/Capric Triglyceride, Isohexadecane, 1,2-He…

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03

Comparison edit

Read side by side