Skin science article
Tatcha The Indigo Cream Versus DRMTLGY Peptide Night Cream
Tatcha The Indigo Cream Versus DRMTLGY Peptide Night Cream This barrier-repair moisturizer is formulated around Squalane and Avena Sativa Kernel Extract to strengthen the skin barrier and calm redness. This anti-aging night moisturizer is formulated around Pal
Tatcha The Indigo Cream Versus DRMTLGY Peptide Night Cream
This barrier-repair moisturizer is formulated around Squalane and Avena Sativa Kernel Extract to strengthen the skin barrier and calm redness.
This anti-aging night moisturizer is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tripeptide-5 to soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Squalane
Dimethicone
Propanediol
Glycerin
Diisostearyl Malate
Oryza Sativa Bran Wax
Behenyl Alcohol
Camellia Sinensis Leaf
Indigofera Tinctoria Leaf Extract
Polygonum Tinctorium Leaf/Stem Extract
Avena Sativa Kernel Extract
Sophora Japonica Flower Extract
Oryza Sativa Germ Oil
Cocos Nucifera Oil
Inositol
Sericin
Tetrasodium Tetracarboxymethyl Naringeninchalcone
Amorphophallus Konjac Root Powder
Sodium Hyaluronate
Sorbitan Tristearate
Trihydroxystearin
Dimethicone/Vinyl Dimethicone Crosspolymer
Beheneth-20
Bis-Diglyceryl Polyacyladipate-2
Ethylhexylglycerin
Butylene Glycol
Sodium Dilauramidoglutamide Lysine
Disodium EDTA
Ethylhexyl Palmitate
Sodium Acrylate/Acryloyldimethyltaurate/Dimethylacrylamide Crosspolymer
Phenoxyethanol
CI 77891
Mica
Water, Squalane, Dimethicone, Propanediol, Glycerin, Diisostearyl Malate, Oryza Sativa Bran Wax, Behenyl Alcohol, Camellia Sinensis Leaf, Indigofera Tinctoria Leaf Extract, Polygonum Tinctorium Leaf/Stem Extract, Avena Sativa Kernel Extract, Sophora Japonica Flower Extract, Oryza Sativa Germ Oil, Cocos Nucifera Oil, Inositol, Sericin, Tetrasodium Tetracarboxymethyl Naringeninchalcone, Amorphophallus Konjac Root Powder, Sodium Hyaluronate, Sorbitan Tristearate, Trihydroxystearin, Dimethicone/Vinyl Dimethicone Crosspolymer, Beheneth-20, Bis-Diglyceryl Polyacyladipate-2, Ethylhexylglycerin, Butylene Glycol, Sodium Dilauramidoglutamide Lysine, Disodium EDTA, Ethylhexyl Palmitate, Sodium Acrylate/Acryloyldimethyltaurate/Dimethylacrylamide Crosspolymer, Phenoxyethanol, CI 77891, Mica
Glyceryl Stearate
C12-15 Alkyl Benzoate
Isopropyl Palmitate
Undecane
Butyrospermum Parkii Butter
Caprylic/Capric Triglyceride
Cetyl Alcohol
PEG-100 Stearate
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine
Palmitoyl Tripeptide-1
Palmitoyl Tripeptide-5
Palmitoyl Tetrapeptide-7
Trifluoroacetyl Tripeptide-2
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Ceramide NP
Ceramide AP
Ceramide EOP
Phytosphingosine
Cholesterol
Tridecane
Allantoin
Tocopherol
Glycol Distearate
Potassium Cetyl Phosphate
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Carbomer
Polysorbate 20
Dextran
Magnesium Chloride
Sodium Hydroxide
Sodium Lauroyl Lactylate
Xanthan Gum
Water, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii Butter, Caprylic/Capric Triglyceride, Cetyl Alcohol, Dimethicone, PEG-100 Stearate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Trifluoroacetyl Tripeptide-2, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Tridecane, Allantoin, Tocopherol, Glycol Distearate, Potassium Cetyl Phosphate, Butylene Glycol, Ethylhexylglycerin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Carbomer, Polysorbate 20, Dextran, Magnesium Chloride, Phenoxyethanol, Disodium EDTA, Sodium Hydroxide, Sodium Lauroyl Lactylate, Xanthan Gum
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!