The History of Whoo Bichup Self-Generating Anti-Aging Concentrate Versus MediCube PDRN Pink Peptide Serum

The History of Whoo Bichup Self-Generating Anti-Aging Concentrate Versus MediCube PDRN Pink Peptide Serum

This anti-aging serum is formulated around Panthenol and Panax Ginseng Root Extract to soften the look of wrinkles and strengthen the skin barrier.

This anti-aging serum is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dipropylene Glycol

PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin

Glyceryl Polymethacrylate

Biosaccharide Gum-1

Dimethicone

1,2-Hexanediol

PEG-150

Methyl Trimethicone

Panthenol

Phenyl Trimethicone

Propylene Glycol

Cyclopentasiloxane

Polymethylsilsesquioxane

Hydrogenated Lecithin

Hydroxyproline

C14-22 Alcohols

Squalane

Panax Ginseng Root Extract

Ophiopogon Japonicus Root Extract

PEG-60 Hydrogenated Castor Oil

Butylene Glycol

Ceramide NP

Rehmannia Glutinosa Root Extract

Angelica Acutiloba Root Extract

Cornus Officinalis Fruit Extract

Nelumbo Nucifera Flower Extract

Nelumbo Nucifera Root Extract

Thymus Vulgaris Extract

Velvet Extract

Tromethamine

Macadamia Ternifolia Seed Oil

Triethylhexanoin

Carbomer

Dimethiconol

Dioscorea Japonica Root Extract

Glycyrrhiza Glabra Root Extract

PEG-10 Rapeseed Sterol

Arachidyl Glucoside

Butyrospermum Parkii Butter

Parfum

Algin

Sodium Polyacrylate

Typha Angustifolia Spike Extract

Cinnamomum Cassia Bark Extract

Paeonia Albiflora Root Extract

Glyceryl Stearate

Scutellaria Baicalensis Root Extract

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Atractylodes Japonica Rhizome Extract

Saposhnikovia Divaricata Root Extract

Zingiber Officinale Root Extract

Zizyphus Jujuba Fruit Extract

Stearic Acid

Angelica Gigas Root Extract

Cholesterol

PEG-100 Stearate

Beta-Glucan

Glycereth-20

Poria Cocos Extract

Theobroma Cacao Extract

Trisodium EDTA

Cordyceps Sinensis Extract

CI 15985

CI 19140

Arbutin

Glycosphingolipids

Oligopeptide-1

Oligopeptide-4

Phospholipids

Acetyl Hexapeptide-8

Copper Tripeptide-1

Hydrolyzed Soy Protein

Oligopeptide-2

Histidine Hcl

Arginine

Lysine

Valine

Threonine

Leucine

Methionine

Isoleucine

Phenylalanine

Tyrosine

Inositol

Cystine

Tryptophan

Folic Acid

Niacinamide

Pyridoxine Hcl

Thiamine Hcl

Calcium Pantothenate

Biotin

Riboflavin

Cyanocobalamin

Water, Glycerin, Dipropylene Glycol, PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, Glyceryl Polymethacrylate, Biosaccharide Gum-1, Dimethicone, 1,2-Hexanediol, PEG-150, Methyl Trimethicone, Panthenol, Phenyl Trimethicone, Propylene Glycol, Cyclopentasiloxane, Polymethylsilsesquioxane, Hydrogenated Lecithin, Hydroxyproline, C14-22 Alcohols, Squalane, Panax Ginseng Root Extract, Ophiopogon Japonicus Root Extract, PEG-60 Hydrogenated Castor Oil, Butylene Glycol, Ceramide NP, Rehmannia Glutinosa Root Extract, Angelica Acutiloba Root Extract, Cornus Officinalis Fruit Extract, Nelumbo Nucifera Flower Extract, Nelumbo Nucifera Root Extract, Thymus Vulgaris Extract, Velvet Extract, Tromethamine, Macadamia Ternifolia Seed Oil, Triethylhexanoin, Carbomer, Dimethiconol, Dioscorea Japonica Root Extract, Glycyrrhiza Glabra Root Extract, PEG-10 Rapeseed Sterol, Arachidyl Glucoside, Butyrospermum Parkii Butter, Parfum, Algin, Sodium Polyacrylate, Typha Angustifolia Spike Extract, Cinnamomum Cassia Bark Extract, Paeonia Albiflora Root Extract, Glyceryl Stearate, Scutellaria Baicalensis Root Extract, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Atractylodes Japonica Rhizome Extract, Saposhnikovia Divaricata Root Extract, Zingiber Officinale Root Extract, Zizyphus Jujuba Fruit Extract, Stearic Acid, Angelica Gigas Root Extract, Cholesterol, PEG-100 Stearate, Beta-Glucan, Glycereth-20, Poria Cocos Extract, Theobroma Cacao Extract, Trisodium EDTA, Cordyceps Sinensis Extract, CI 15985, CI 19140, Arbutin, Glycosphingolipids, Oligopeptide-1, Oligopeptide-4, Phospholipids, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hydrolyzed Soy Protein, Oligopeptide-2, Histidine Hcl, Arginine, Lysine, Valine, Threonine, Leucine, Methionine, Isoleucine, Phenylalanine, Tyrosine, Inositol, Cystine, Tryptophan, Folic Acid, Niacinamide, Pyridoxine Hcl, Thiamine Hcl, Calcium Pantothenate, Biotin, Riboflavin, Cyanocobalamin

Isopropyl Myristate

Glycereth-26

Sodium DNA

Polyglycerin-3

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Polyisobutene

Milt Extract

Glyceryl Acrylate/Acrylic Acid Copolymer

Pvm/Ma Copolymer

Ethylhexylglycerin

Caprylyl Glycol

Melia Azadirachta Leaf Extract

Adenosine

Caprylyl/Capryl Glucoside

Sorbitan Oleate

Melia Azadirachta Flower Extract

Sodium Hyaluronate

Disodium EDTA

Curcuma Longa Root Extract

Hydrolyzed Collagen

Ubiquinone

Ocimum Sanctum Leaf Extract

Corallina Officinalis Extract

Palmitoyl Pentapeptide-4

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Salmon Egg Extract

Atelocollagen

Water, Glycerin, Dipropylene Glycol, Isopropyl Myristate, Glycereth-26, Niacinamide, 1,2-Hexanediol, Sodium DNA, Butylene Glycol, Polyglycerin-3, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polyisobutene, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Milt Extract, Tromethamine, Glyceryl Acrylate/Acrylic Acid Copolymer, Pvm/Ma Copolymer, Ethylhexylglycerin, Caprylyl Glycol, Parfum, Melia Azadirachta Leaf Extract, Adenosine, Caprylyl/Capryl Glucoside, Sorbitan Oleate, Melia Azadirachta Flower Extract, Sodium Hyaluronate, Disodium EDTA, Curcuma Longa Root Extract, Cyanocobalamin, Hydrolyzed Collagen, Ubiquinone, Ocimum Sanctum Leaf Extract, Corallina Officinalis Extract, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Copper Tripeptide-1, Acetyl Hexapeptide-8, Salmon Egg Extract, Atelocollagen

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Cyanocobalamin is the manufactured version of vitamin B12. It has skin soothing, antioxidant, and barrier protecting properties. Topical cyanocobalamin is used to treat skin irritation and atopic dermatitis.

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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