Skin science article
The INKEY List Bakuchiol Moisturizer Versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment
The INKEY List Bakuchiol Moisturizer Versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment This anti-aging moisturizer is formulated around Bakuchiol and Squalane to soften the look of wrinkles and refine skin texture. This anti-aging treatment
The INKEY List Bakuchiol Moisturizer Versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment
This anti-aging moisturizer is formulated around Bakuchiol and Squalane to soften the look of wrinkles and refine skin texture.
This anti-aging treatment is formulated around Bakuchiol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Squalane
Glycerin
Propanediol
Plukenetia Volubilis Seed Oil
Dicaprylyl Carbonate
Bakuchiol
Phenoxyethanol
Sodium Caproyl Prolinate
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Carbomer
Sodium Hydroxide
Ethylhexylglycerin
Sodium Stearoyl Glutamate
Polysorbate 60
Phytic Acid
Glyceryl Polyacrylate
Sorbitan Isostearate
Tocopherol
Water, Squalane, Glycerin, Propanediol, Plukenetia Volubilis Seed Oil, Dicaprylyl Carbonate, Bakuchiol, Phenoxyethanol, Sodium Caproyl Prolinate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Carbomer, Sodium Hydroxide, Ethylhexylglycerin, Sodium Stearoyl Glutamate, Polysorbate 60, Phytic Acid, Glyceryl Polyacrylate, Sorbitan Isostearate, Tocopherol
Dimethicone
Pentaerythrityl Tetraisostearate
Isononyl Isononanoate
Butylene Glycol
Arachidyl Alcohol
Glyceryl Polymethacrylate
Dimethicone Crosspolymer
Behenyl Alcohol
PEG-75 Shea Butter Glycerides
Glyceryl Stearate
C12-15 Alkyl Benzoate
Polysorbate 20
Tetrahexyldecyl Ascorbate
Retinol
Ceramide Ng
Palmitoyl Tetrapeptide-7
Palmitoyl Hexapeptide-12
Sodium Hyaluronate
Dipotassium Glycyrrhizate
Glycyrrhiza Glabra Root Extract
Avena Sativa Kernel Extract
Arctium Lappa Root Extract
Salix Alba Bark Extract
Glycine Soja Sterols
Lecithin
Allantoin
Tocopheryl Acetate
Hydrolyzed Soy Protein
Palmitoyl Tripeptide-1
Tribehenin
Caprylyl Glycol
Dipeptide-2
Polygonum Cuspidatum Root Extract
PEG-10 Phytosterol
PEG-8
Magnesium Aluminum Silicate
Arachidyl Glucoside
Chrysin
Pentylene Glycol
Sodium Acrylates Copolymer
Steareth-20
Cetearyl Alcohol
Coco-Glucoside
Hesperidin Methyl Chalcone
N-Hydroxysuccinimide
Disodium EDTA
Benzoic Acid
Water, Dimethicone, Pentaerythrityl Tetraisostearate, Isononyl Isononanoate, Butylene Glycol, Bakuchiol, Arachidyl Alcohol, Glyceryl Polymethacrylate, Dimethicone Crosspolymer, Behenyl Alcohol, Glycerin, PEG-75 Shea Butter Glycerides, Glyceryl Stearate, C12-15 Alkyl Benzoate, Polysorbate 20, Tetrahexyldecyl Ascorbate, Retinol, Ceramide Ng, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra Root Extract, Avena Sativa Kernel Extract, Arctium Lappa Root Extract, Salix Alba Bark Extract, Glycine Soja Sterols, Lecithin, Allantoin, Tocopheryl Acetate, Hydrolyzed Soy Protein, Palmitoyl Tripeptide-1, Sodium Hydroxide, Tribehenin, Caprylyl Glycol, Dipeptide-2, Polygonum Cuspidatum Root Extract, PEG-10 Phytosterol, PEG-8, Magnesium Aluminum Silicate, Arachidyl Glucoside, Chrysin, Pentylene Glycol, Sodium Acrylates Copolymer, Steareth-20, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Alcohol, Coco-Glucoside, Hesperidin Methyl Chalcone, N-Hydroxysuccinimide, Disodium EDTA, Phenoxyethanol, Benzoic Acid, Ethylhexylglycerin
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Bakuchiol is a plant-derived antioxidant from the seeds of the Psoralea corylifolia plant. It has antimicrobial, emollient, skin conditioning, and antioxidant properties.
You'll likely see it called a "retinol replacement" but the two are technically not related. This is because bakuchiol is able to flip many of the same switches in your skin cells to tell them to:
1) produce more collagen (type I, III, and IV) 2) activate the same genes retinoids do
Unlike retinoids, this ingredient will not increase photosensitivity and is safe to use during pregnancy (but please still check in with your doctor!).
The flagship clinical trial from Dhaliwal et al. 2019 found 0.5% bakuchiol (twice daily) and 0.5% retinol (once daily) reduced wrinkles and hyperpigmentation equally, but bakuchiol had significantly less irritation.
Systematic reviews also back this up:
Bakuchiol is comparable to retinol for photoaging but with better tolerability. It also has mild antibacterial properties against Cutibacterium acnes and antifungal activity in vitro against Candida and dermatophytes.
The reason bakuchiol works well is due to its structure; it is a meroterpene phenol, or a hybrid molecule. The phenol half acts as an antioxidant while the terpene half is fat-loving. This helps the molecule slip through the skin barrier.
This ingredient is usually used between 0.5-2%. Only one case of contact dermatitis has ever been reported for this ingredient.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.
It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!