Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

The INKEY List Niacinamide Oil Control Serum Versus Paula's Choice Defense Antioxidant Pore Purifier

The INKEY List Niacinamide Oil Control Serum Versus Paula's Choice Defense Antioxidant Pore Purifier This oil-control serum is formulated around Niacinamide to balance excess oil and refine the look of pores. This pore-care treatment is formulated around Ascor

The INKEY List Niacinamide Oil Control Serum Versus Paula's Choice Defense Antioxidant Pore Purifier

This oil-control serum is formulated around Niacinamide to balance excess oil and refine the look of pores.

This pore-care treatment is formulated around Ascorbyl Glucoside and Salicylic Acid to refine the look of pores and balance excess oil.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Niacinamide

Glycerin

Propanediol

Butylene Glycol

Phenoxyethanol

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Hydroxyethylcellulose

Phospholipids

Squalane

Xanthan Gum

Glycine Soja Oil

Allantoin

Sodium Phytate

Polysorbate 60

Panthenol

Glycolipids

Leuconostoc/Radish Root Ferment Filtrate

Sorbitan Isostearate

Glycine Soja Sterols

Citric Acid

Hyaluronic Acid

Disodium Phosphate

Sodium Phosphate

Water, Niacinamide, Glycerin, Propanediol, Butylene Glycol, Phenoxyethanol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyethylcellulose, Phospholipids, Squalane, Xanthan Gum, Glycine Soja Oil, Allantoin, Sodium Phytate, Polysorbate 60, Panthenol, Glycolipids, Leuconostoc/Radish Root Ferment Filtrate, Sorbitan Isostearate, Glycine Soja Sterols, Citric Acid, Hyaluronic Acid, Disodium Phosphate, Sodium Phosphate

Ethoxydiglycol

Ascorbyl Glucoside

Salicylic Acid

Camellia Sinensis Callus

Glycyrrhiza Glabra Root Extract

Potassium Azeloyl Diglycinate

Coffea Arabica Fruit Extract

Ceramide NP

Vitis Vinifera Seed Extract

Panax Ginseng Root Extract

Phytic Acid

Epigallocatechin Gallate

Adenosine

Ubiquinone

Calendula Officinalis Flower Extract

Lonicera Caprifolium Flower Extract

Sodium Hyaluronate

Lecithin

Centella Asiatica Extract

Sucrose Stearate

Glycine Soja Seed Extract

Hydrogenated Lecithin

Carbomer

Tetrasodium Glutamate Diacetate

Caprylic/Capric Triglyceride

Caprylyl Glycol

Polysorbate 20

Polyglyceryl-10 Stearate

Sodium Hydroxide

Ethylhexylglycerin

Water, Propanediol, Butylene Glycol, Ethoxydiglycol, Glycerin, Ascorbyl Glucoside, Panthenol, Salicylic Acid, Camellia Sinensis Callus, Glycyrrhiza Glabra Root Extract, Potassium Azeloyl Diglycinate, Coffea Arabica Fruit Extract, Ceramide NP, Vitis Vinifera Seed Extract, Panax Ginseng Root Extract, Niacinamide, Phytic Acid, Epigallocatechin Gallate, Adenosine, Ubiquinone, Calendula Officinalis Flower Extract, Lonicera Caprifolium Flower Extract, Sodium Hyaluronate, Lecithin, Centella Asiatica Extract, Sucrose Stearate, Glycine Soja Seed Extract, Hydrogenated Lecithin, Carbomer, Tetrasodium Glutamate Diacetate, Caprylic/Capric Triglyceride, Caprylyl Glycol, Polysorbate 20, Polyglyceryl-10 Stearate, Hydroxyethylcellulose, Sodium Hydroxide, Ethylhexylglycerin, Phenoxyethanol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydroxyethylcellulose is used to improve the texture of products. It is created from a chemical reaction involving ethylene oxide and alkali-cellulose. Cellulose is a sugar found in plant cell walls and help give plants structure.

This ingredient helps stabilize products by preventing ingredients from separating. It can also help thicken the texture of a product.

This ingredient can also be found in pill medicines to help our bodies digest other ingredients.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
  4. 04Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
  5. 05It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
  6. 06Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
  7. 07A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
  8. 08Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
  9. 09The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure …
  10. 10Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
  11. 11Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  12. 12Topically, glycerin does several things at once:
  13. 13Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  14. 14Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  15. 15This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  16. 16Just know very high concentrations (>40%) can feel tacky in low humidity.
  17. 17Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  18. 18This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.
  19. 19It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.
  20. 20Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.
Source · skinsort.com
02

Product index

Related product references

Product

The Inkey List Symbright Moisturizer

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Source: incidecoder.comView reference →

Product

The Inkey List Retinol Serum

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Source: incidecoder.comView reference →
03

Comparison edit

Read side by side