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Skin science article

The INKEY List Retinol Serum Versus Principia Emulsão Facial GR-2

The INKEY List Retinol Serum Versus Principia Emulsão Facial GR-2 This anti-aging serum is formulated around Retinyl Acetate and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and refine skin texture. This anti-aging serum is formulated around Hydroxy

The INKEY List Retinol Serum Versus Principia Emulsão Facial GR-2

This anti-aging serum is formulated around Retinyl Acetate and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and refine skin texture.

This anti-aging serum is formulated around Hydroxypinacolone Retinoate to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Propanediol

Dicaprylyl Carbonate

Retinyl Acetate

Dimethicone

Phenoxyethanol

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Caprylyl Glycol

Phospholipids

Squalane

Glycine Soja Oil

Carbomer

Polysorbate 60

Tocopheryl Acetate

Glycolipids

Sodium Hydroxide

Sodium Phytate

Sorbitan Isostearate

Glycine Soja Sterols

Tetrahexyldecyl Ascorbate

Leuconostoc/Radish Root Ferment Filtrate

Hyaluronic Acid

Sodium Lactate

Tocopherol

Polysorbate 20

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Water, Glycerin, Butylene Glycol, Propanediol, Dicaprylyl Carbonate, Retinyl Acetate, Dimethicone, Phenoxyethanol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Caprylyl Glycol, Phospholipids, Squalane, Glycine Soja Oil, Carbomer, Polysorbate 60, Tocopheryl Acetate, Glycolipids, Sodium Hydroxide, Sodium Phytate, Sorbitan Isostearate, Glycine Soja Sterols, Tetrahexyldecyl Ascorbate, Leuconostoc/Radish Root Ferment Filtrate, Hyaluronic Acid, Sodium Lactate, Tocopherol, Polysorbate 20, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1

Xanthan Gum

Sodium Gluconate

Sodium Hyaluronate

Polyglyceryl-6 Polyricinoleate

Polyglyceryl-10 Dioleate

Dimethyl Isosorbide

Hydroxypinacolone Retinoate

Citric Acid

Water, Xanthan Gum, Sodium Gluconate, Sodium Hyaluronate, Propanediol, Polyglyceryl-6 Polyricinoleate, Polyglyceryl-10 Dioleate, Dimethyl Isosorbide, Hydroxypinacolone Retinoate, Tocopheryl Acetate, Citric Acid, Phenoxyethanol, Caprylyl Glycol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

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Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.
  4. 04Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.
  5. 05Some studies suggest betaine may support making skin tone more even.
  6. 06Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.
  7. 07Betaine is also known as trimethylglycine.
  8. 08Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
  9. 09The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure …
  10. 10Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
  11. 11Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
  12. 12There are two forms of panthenol: D and L.
  13. 13D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
  14. 14Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
  15. 15Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
  16. 16This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
  17. 17Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
  18. 18This ingredient is also referred to as pro-vitamin B5.
  19. 19Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
  20. 20It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
Source · skinsort.com
02

Product index

Related product references

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Product

The Inkey List Retinol

The Inkey List Retinol The Inkey List Retinol ingredients explained: Water (Aqua/Eau), Glycerin, Butylene Glycol, Propanediol, Dicaprylyl Carbonate, Tocopherol, Hydroxyethyl Acrylate/Sodium…

Source: incidecoder.comView reference →
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Comparison edit

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