Skin science article
The Originote 2 In 1 Lash & Brow Serum Versus Glad2Glow Berry Peptide Eye Cream
The Originote 2 In 1 Lash & Brow Serum Versus Glad2Glow Berry Peptide Eye Cream This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Pentapeptide-4 to soften the look of wrinkles. What's inside Key Ingredients Benefits Concerns Ingred
The Originote 2 In 1 Lash & Brow Serum Versus Glad2Glow Berry Peptide Eye Cream
This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Pentapeptide-4 to soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Propylene Glycol
Glycerin
Butylene Glycol
Glycereth-26
Hydrolyzed Collagen
Propanediol
1,2-Hexanediol
Hydroxyacetophenone
Sodium Hyaluronate
Hydroxyethylcellulose
Sodium Chloride
PEG-40 Hydrogenated Castor Oil
Xanthan Gum
Hydrolyzed Pea Protein
Ethylhexylglycerin
Tocopherol
Panax Ginseng Root Extract
Biotin
Tripeptide-1
Palmitoyl Pentapeptide-4
Water, Propylene Glycol, Glycerin, Butylene Glycol, Glycereth-26, Hydrolyzed Collagen, Propanediol, 1,2-Hexanediol, Hydroxyacetophenone, Sodium Hyaluronate, Hydroxyethylcellulose, Sodium Chloride, PEG-40 Hydrogenated Castor Oil, Xanthan Gum, Hydrolyzed Pea Protein, Ethylhexylglycerin, Tocopherol, Panax Ginseng Root Extract, Biotin, Tripeptide-1, Palmitoyl Pentapeptide-4
Dimethicone
Methylpropanediol
Coco-Caprylate/Caprate
Maris Aqua
Cyclopentasiloxane
Cetyl Alcohol
Octyldodecanol
Glyceryl Stearate
Niacinamide
Cyclohexasiloxane
Methyl Hydrogenated Rosinate
Ammonium Acryloyldimethyltaurate/Vp Copolymer
PEG-75 Stearate
Tocopheryl Acetate
Steareth-20
Ceteth-20
Bisabolol
Pentylene Glycol
Lactobacillus/Soymilk Ferment Filtrate
Gentiana Scabra Root Extract
Hydroxyphenyl Propamidobenzoic Acid
Caffeine
Ceramide EOP
Ceramide AP
Ceramide Ns
Ceramide Ng
Ceramide As
Acetyl Tetrapeptide-5
Dipeptide Diaminobutyroyl Benzylamide Diacetate
Chondrus Crispus Extract
Smithsonite Extract
Peumus Boldus Leaf Extract
Moringa Oleifera Seed Extract
Zea Mays Kernel Extract
Palmaria Palmata Extract
Phytosteryl/Octyldodecyl Lauroyl Glutamate
Ceramide NP
Echinacea Purpurea Extract
Ascorbyl Palmitate
Lycium Barbarum Fruit Extract
Trehalose
Sophora Flavescens Root Extract
Aloe Barbadensis Leaf Extract
Hydrogenated Lecithin
Dendrobium Nobile Stem Extract
Erythritol
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
Disodium EDTA
Cyclodextrin
Polysorbate 20
Carbomer
Arginine
Water, Glycerin, Dimethicone, Methylpropanediol, Coco-Caprylate/Caprate, Maris Aqua, Cyclopentasiloxane, Cetyl Alcohol, Octyldodecanol, Glyceryl Stearate, Niacinamide, Cyclohexasiloxane, Hydroxyacetophenone, 1,2-Hexanediol, Methyl Hydrogenated Rosinate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, PEG-75 Stearate, Tocopheryl Acetate, Steareth-20, Ceteth-20, Butylene Glycol, Bisabolol, Pentylene Glycol, Lactobacillus/Soymilk Ferment Filtrate, Gentiana Scabra Root Extract, Hydroxyphenyl Propamidobenzoic Acid, Caffeine, Sodium Hyaluronate, Palmitoyl Pentapeptide-4, Tocopherol, Ceramide EOP, Ceramide AP, Ceramide Ns, Ceramide Ng, Ceramide As, Acetyl Tetrapeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Chondrus Crispus Extract, Smithsonite Extract, Peumus Boldus Leaf Extract, Moringa Oleifera Seed Extract, Zea Mays Kernel Extract, Palmaria Palmata Extract, Phytosteryl/Octyldodecyl Lauroyl Glutamate, Ceramide NP, Echinacea Purpurea Extract, Ascorbyl Palmitate, Lycium Barbarum Fruit Extract, Trehalose, Sophora Flavescens Root Extract, Aloe Barbadensis Leaf Extract, Hydrogenated Lecithin, Dendrobium Nobile Stem Extract, Erythritol, Xanthan Gum, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Disodium EDTA, Cyclodextrin, Polysorbate 20, Carbomer, Arginine
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Hydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.
As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.
Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.
This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.
You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.
Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.
An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.
So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.
Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.
You might know this ingredient as Matrixyl. It is a synthetic peptide made up of five amino acids attached to a palmitic acid, a fatty acid that helps it absorb into skin more easily.
As a signal peptide, Matrixyl acts like a little messenger. Once it reaches your skin cells, it tells them to ramp up production of collagen, elastin, and other proteins that keep skin looking firm and smooth.
A 12 week clinical study found that a moisturizer containing just 3 ppm of Matrixyl led to a significant improvement in fine-lines and wrinkles. Another study showed an 18% reduction in wrinkle depth, 37% reduction in wrinkle thickness, and a 21% improvement in skin firmness after just 28 days of twice-daily use.
The coolest part is that it works at incredibly low concentrations (like 0.0003%) and it plays well with other actives.
The CIR (Cosmetic Ingredient Review) panel found it to be non-sensitizing across multiple tests and human patch tests also showed no irritation or sensitization.
Fun fact: Matrixyl was originally developed by French company Sederma and Procter & Gamble.
Read more about other common types of peptides here:
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.