Skin science article
The [pH]ix The [pH]iller Peptide+ Serum Versus Peach & Lily Copper Peptide Pro Firming Serum
The [pH]ix The [pH]iller Peptide+ Serum Versus Peach & Lily Copper Peptide Pro Firming Serum This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Tripeptide-10 Citrulline to soften the look of wrinkles. This anti-aging serum is formulated around
The [pH]ix The [pH]iller Peptide+ Serum Versus Peach & Lily Copper Peptide Pro Firming Serum
This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Tripeptide-10 Citrulline to soften the look of wrinkles.
This anti-aging serum is formulated around Copper Tripeptide-1 and Acetyl Hexapeptide-8 to soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
No concerns
Ingredients Side-by-side
Water
Nannochloropsis Oculata Extract
Pullulan
Acetyl Hexapeptide-8
Acmella Oleracea Extract
Allantoin
Euterpe Oleracea Fruit Extract
Epilobium Angustifolium Flower/Leaf/Stem Extract
Glycerin
Ascorbic Acid
Pseudoalteromonas Ferment Extract
Hydrolyzed Wheat Protein
Hydrolyzed Soy Protein
Tripeptide-10 Citrulline
Tripeptide-1
Lecithin
Butylene Glycol
Xanthan Gum
Carbomer
Triethanolamine
Caprylyl Glycol
Dimethicone
Cetyl Alcohol
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Glyceryl Stearate
Caprylic/Capric Triglyceride
Acrylamide/Sodium Acrylate Copolymer
Paraffinum Liquidum
Trideceth-6
Propylene Glycol
Diazolidinyl Urea
Iodopropynyl Butylcarbamate
Tetrasodium EDTA
Phenoxyethanol
Sodium Benzoate
Alcohol
Potassium Sorbate
Water, Nannochloropsis Oculata Extract, Pullulan, Acetyl Hexapeptide-8, Acmella Oleracea Extract, Allantoin, Euterpe Oleracea Fruit Extract, Epilobium Angustifolium Flower/Leaf/Stem Extract, Glycerin, Ascorbic Acid, Pseudoalteromonas Ferment Extract, Hydrolyzed Wheat Protein, Hydrolyzed Soy Protein, Tripeptide-10 Citrulline, Tripeptide-1, Lecithin, Butylene Glycol, Xanthan Gum, Carbomer, Triethanolamine, Caprylyl Glycol, Dimethicone, Cetyl Alcohol, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Glyceryl Stearate, Caprylic/Capric Triglyceride, Acrylamide/Sodium Acrylate Copolymer, Paraffinum Liquidum, Trideceth-6, Propylene Glycol, Diazolidinyl Urea, Iodopropynyl Butylcarbamate, Tetrasodium EDTA, Phenoxyethanol, Sodium Benzoate, Alcohol, Potassium Sorbate
Dipropylene Glycol
1,2-Hexanediol
Betaine
Copper Tripeptide-1
Palmitoyl Tripeptide-1
Tetrapeptide-21
Tetrapeptide-30
Heptasodium Hexacarboxymethyl Dipeptide-12
Acetyl Tetrapeptide-5
Palmitoyl Tripeptide-38
Palmitoyl Pentapeptide-4
Dipeptide-2
Hexapeptide-9
Nonapeptide-1
Collagen Extract
Serine
Methionine
Cysteine
Arginine
Alpha-Glucan Oligosaccharide
Sodium PCA
Ulmus Davidiana Root Extract
Cichorium Intybus Root Extract
Helianthus Tuberosus Root Extract
Tremella Fuciformis Extract
Fomes Officinalis Extract
Lentinus Edodes Extract
Pyrus Malus Fruit Extract
Lens Esculenta Fruit Extract
Citrullus Lanatus Fruit Extract
Sodium Acetylated Hyaluronate
Hydrolyzed Hyaluronic Acid
Hyaluronic Acid
Sodium Hyaluronate
Sodium Hyaluronate Crosspolymer
Potassium Hyaluronate
Squalane
Ficus Carica Fruit Extract
Cynanchum Atratum Extract
Hydroxypropyltrimonium Hyaluronate
Ocimum Sanctum Leaf Extract
Melia Azadirachta Leaf Extract
Curcuma Longa Root Extract
Corallina Officinalis Extract
Solanum Melongena Fruit Extract
Coccinia Indica Fruit Extract
Gellan Gum
Adenosine
Aloe Barbadensis Flower Extract
Melia Azadirachta Flower Extract
Polyglyceryl-10 Eicosanedioate/Tetradecanedioate
Polyquaternium-51
Sodium Polyacryloyldimethyl Taurate
Hydroxypropyl Cyclodextrin
Ethylhexylglycerin
Hydroxyethylcellulose
Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Betaine, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Tetrapeptide-21, Tetrapeptide-30, Heptasodium Hexacarboxymethyl Dipeptide-12, Acetyl Tetrapeptide-5, Palmitoyl Tripeptide-38, Palmitoyl Pentapeptide-4, Dipeptide-2, Tripeptide-1, Hexapeptide-9, Nonapeptide-1, Collagen Extract, Serine, Methionine, Cysteine, Arginine, Acmella Oleracea Extract, Alpha-Glucan Oligosaccharide, Sodium PCA, Ulmus Davidiana Root Extract, Cichorium Intybus Root Extract, Helianthus Tuberosus Root Extract, Tremella Fuciformis Extract, Fomes Officinalis Extract, Lentinus Edodes Extract, Pyrus Malus Fruit Extract, Lens Esculenta Fruit Extract, Citrullus Lanatus Fruit Extract, Sodium Acetylated Hyaluronate, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Potassium Hyaluronate, Squalane, Ficus Carica Fruit Extract, Cynanchum Atratum Extract, Hydroxypropyltrimonium Hyaluronate, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Curcuma Longa Root Extract, Corallina Officinalis Extract, Solanum Melongena Fruit Extract, Coccinia Indica Fruit Extract, Gellan Gum, Butylene Glycol, Adenosine, Aloe Barbadensis Flower Extract, Melia Azadirachta Flower Extract, Polyglyceryl-10 Eicosanedioate/Tetradecanedioate, Polyquaternium-51, Sodium Polyacryloyldimethyl Taurate, Hydroxypropyl Cyclodextrin, Ethylhexylglycerin, Hydroxyethylcellulose, Caprylyl Glycol
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
We don't have a description for Acmella Oleracea Extract yet.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Tripeptide-1, also known as GHK), is a small, three-amino-acid peptide made up of glycine, histidine, and lysine.
This ingredient is a signal peptide and tell your skin to start producing fresh collagen, elastin, and other key structural proteins. This helps maintain firmness and reduces the look of fine-lines/wrinkles.
GHK is also unique because is also acts as a carrier peptide. It binds to and transports copper ions (forming the complex GHK-Cu). This form has been studied for decades and is known to stimulate wound healing, boost antioxidant defenses, and promote collagen/elastin synthesis.
In-vitro studies show both GHK and GHK-CU increase fibroblast activity that enhances the production of collagen, elastin, fibronectin, and other extracellular matrix components.
Both of these compounds also help balance enzymes that control collagen breakdown.
Human studies (in-vivo) using GHK-Cu creams have reported visible improvements to skin density, elasticity, and wrinkle depth after several weeks of use.
A small clinical study also found topical collagen tripeptide improved wrinkle appearance and skin elasticity in women after four weeks.
While these results are promising, most research is based on GHK-Cu or its derivatives rather than Tripeptide-1 alone (Palmitoyl Tripeptide-1 is a famous derivative of GHK). However, the consensus still supports GHK as a potent skin-signaling molecule that can encourage regeneration and maintain youthful looking skin.
Fun fact: GHK is a naturally occurring fragment of type 1 collagen that can be found in human plasma, saliva, and urine.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!