Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

The Potions Peptide Ampoule Versus rhode Peptide Glazing Fluid

The Potions Peptide Ampoule Versus rhode Peptide Glazing Fluid This anti-aging ampoule is formulated around Acetyl Hexapeptide-8 and Palmitoyl Pentapeptide-4 to soften the look of wrinkles and strengthen the skin barrier. This barrier-repair serum is formulate

By Peptide Skincare & Beauty Editorial TeamPublished

The Potions Peptide Ampoule Versus rhode Peptide Glazing Fluid

This anti-aging ampoule is formulated around Acetyl Hexapeptide-8 and Palmitoyl Pentapeptide-4 to soften the look of wrinkles and strengthen the skin barrier.

This barrier-repair serum is formulated around Sclerocarya Birrea Seed Oil and Niacinamide to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Butylene Glycol

Pentylene Glycol

Dehydroxanthan Gum

Tranexamoyl Dipeptide-22

Hexapeptide-9

Tripeptide-29

Tripeptide-1

Acetyl Hexapeptide-8

Nicotinoyl Dipeptide-22

Palmitoyl Pentapeptide-4

Copper Tripeptide-1

Water, Butylene Glycol, Pentylene Glycol, Dehydroxanthan Gum, Tranexamoyl Dipeptide-22, Hexapeptide-9, Tripeptide-29, Tripeptide-1, Acetyl Hexapeptide-8, Nicotinoyl Dipeptide-22, Palmitoyl Pentapeptide-4, Copper Tripeptide-1

Glycerin

Sclerocarya Birrea Seed Oil

Niacinamide

Tetradecane

Capryloyl Glycerin/Sebacic Acid Copolymer

Diheptyl Succinate

Benzyl Alcohol

Glyceryl Oleate

Sucrose Palmitate

Hydroxyacetophenone

Carbomer

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Caprylyl Glycol

Sodium Hydroxide

Disodium Phosphate

Sodium Phosphate

Sodium Hyaluronate

Dilauryl Thiodipropionate

Water, Butylene Glycol, Glycerin, Sclerocarya Birrea Seed Oil, Niacinamide, Tetradecane, Capryloyl Glycerin/Sebacic Acid Copolymer, Diheptyl Succinate, Benzyl Alcohol, Glyceryl Oleate, Sucrose Palmitate, Hydroxyacetophenone, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Glycol, Sodium Hydroxide, Disodium Phosphate, Sodium Phosphate, Sodium Hyaluronate, Dilauryl Thiodipropionate, Acetyl Hexapeptide-8

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
  4. 04Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
  5. 05Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
  6. 06Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  7. 07Topically, glycerin does several things at once:
  8. 08Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  9. 09Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  10. 10This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  11. 11Just know very high concentrations (>40%) can feel tacky in low humidity.
  12. 12Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  13. 13Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
  14. 14In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
  15. 15Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
  16. 16"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
  17. 17Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
  18. 18So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
  19. 19You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Source · skinsort.com ⟶
03

Comparison edit

Read side by side

Continue reading

Related articles