Skin science article
The Purest Solutions Peptide Complex Serum Versus rhode Peptide Glazing Fluid
The Purest Solutions Peptide Complex Serum Versus rhode Peptide Glazing Fluid This anti-aging serum is formulated around Sodium Hyaluronate and Acetyl Hexapeptide-8 to soften the look of wrinkles and hydrate skin. This barrier-repair serum is formulated around
The Purest Solutions Peptide Complex Serum Versus rhode Peptide Glazing Fluid
This anti-aging serum is formulated around Sodium Hyaluronate and Acetyl Hexapeptide-8 to soften the look of wrinkles and hydrate skin.
This barrier-repair serum is formulated around Sclerocarya Birrea Seed Oil and Niacinamide to strengthen the skin barrier and soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Phenethyl Alcohol
Propylene Glycol
Cetearyl Isononanoate
Sodium Polyacrylate
Propanediol
1,2-Hexanediol
Cetearyl Alcohol
Ceteareth-20
Glycerin
Hydrogenated Polydecene
Glyceryl Stearate
Trideceth-6
Acmella Oleracea Extract
Ceteareth-12
Cetyl Palmitate
Sodium PCA
Pentylene Glycol
Erythritol
Ethylhexylglycerin
Caprylyl Glycol
Carrageenan
Sodium Acetylated Hyaluronate
Sodium Hyaluronate
Xanthan Gum
Sodium Hyaluronate Crosspolymer
Acetyl Hexapeptide-8
Hydrolyzed Sodium Hyaluronate
Water, Phenethyl Alcohol, Propylene Glycol, Cetearyl Isononanoate, Sodium Polyacrylate, Propanediol, 1,2-Hexanediol, Cetearyl Alcohol, Ceteareth-20, Glycerin, Hydrogenated Polydecene, Glyceryl Stearate, Trideceth-6, Acmella Oleracea Extract, Ceteareth-12, Cetyl Palmitate, Sodium PCA, Pentylene Glycol, Erythritol, Ethylhexylglycerin, Caprylyl Glycol, Carrageenan, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Xanthan Gum, Sodium Hyaluronate Crosspolymer, Acetyl Hexapeptide-8, Hydrolyzed Sodium Hyaluronate
Butylene Glycol
Sclerocarya Birrea Seed Oil
Niacinamide
Tetradecane
Capryloyl Glycerin/Sebacic Acid Copolymer
Diheptyl Succinate
Benzyl Alcohol
Glyceryl Oleate
Sucrose Palmitate
Hydroxyacetophenone
Carbomer
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Sodium Hydroxide
Disodium Phosphate
Sodium Phosphate
Dilauryl Thiodipropionate
Water, Butylene Glycol, Glycerin, Sclerocarya Birrea Seed Oil, Niacinamide, Tetradecane, Capryloyl Glycerin/Sebacic Acid Copolymer, Diheptyl Succinate, Benzyl Alcohol, Glyceryl Oleate, Sucrose Palmitate, Hydroxyacetophenone, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Glycol, Sodium Hydroxide, Disodium Phosphate, Sodium Phosphate, Sodium Hyaluronate, Dilauryl Thiodipropionate, Acetyl Hexapeptide-8
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!