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Skin science article

Timeless Skin Care CoEnzyme Q10 Serum Versus Paula's Choice Resist Super Antioxidant Serum

Timeless Skin Care CoEnzyme Q10 Serum Versus Paula's Choice Resist Super Antioxidant Serum This anti-aging serum is formulated around Matrixyl 3000 and Ubiquinone to soften the look of wrinkles and hydrate skin. This anti-aging serum is formulated around Tetra

Timeless Skin Care CoEnzyme Q10 Serum Versus Paula's Choice Resist Super Antioxidant Serum

This anti-aging serum is formulated around Matrixyl 3000 and Ubiquinone to soften the look of wrinkles and hydrate skin.

This anti-aging serum is formulated around Tetrahexyldecyl Ascorbate and Palmitoyl Tripeptide-5 to soften the look of wrinkles and brighten dull-looking skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Matrixyl 3000

Ubiquinone

Aloe Barbadensis Leaf Extract

Glycerin

Hyaluronic Acid

Tocopherol

Benzyl Alcohol

Dehydroacetic Acid

Water, Matrixyl 3000, Ubiquinone, Aloe Barbadensis Leaf Extract, Glycerin, Hyaluronic Acid, Tocopherol, Benzyl Alcohol, Dehydroacetic Acid

Cyclopentasiloxane

Dimethicone

Tetrahexyldecyl Ascorbate

Palmitoyl Tripeptide-5

Ceramide NP

Tocotrienols

Thioctic Acid

Tocopheryl Acetate

Magnesium Ascorbyl Phosphate

Ferulic Acid

Beta-Glucan

Superoxide Dismutase

Epigallocatechin Gallate

Ergothioneine

Glutathione

Xanthophylls

Glycine Soja Seed Extract

Arctostaphylos Uva Ursi Leaf Extract

Lupinus Albus Seed Extract

Curcuma Longa Root

Elaeis Guineensis Oil

Phenoxyethanol

Cyclopentasiloxane, Dimethicone, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Ceramide NP, Tocotrienols, Tocopherol, Ubiquinone, Thioctic Acid, Tocopheryl Acetate, Magnesium Ascorbyl Phosphate, Ferulic Acid, Beta-Glucan, Superoxide Dismutase, Epigallocatechin Gallate, Ergothioneine, Glutathione, Xanthophylls, Glycine Soja Seed Extract, Glycerin, Arctostaphylos Uva Ursi Leaf Extract, Lupinus Albus Seed Extract, Curcuma Longa Root, Elaeis Guineensis Oil, Phenoxyethanol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Ubiquinone (Coenzyme Q10) is a molecule already found in our bodies. It is a potent antioxidant and skin-soothing ingredient.

Aging and environmental exposure diminishes our skin's natural ubiquinone levels. This is much like our natural collagen and elastin.

The good news is: studies show applying this ingredient topically replenishes ubiquinone levels in our skin. This also comes with a ton of skin benefits. These benefits include:

Ubiquinone is considered a large molecule and cannot be absorbed into the lower layers of skin. This is why it is believed to be such an effective antioxidant: it protects our skin in the upper layers and prevents damage in the deeper layers.

When used in sunscreen, ubiquinone is shown to increase ingredient stability, increase SPF factor, and add to infrared protection.

Fun fact: ubiquinone is fat-soluble.

Similar Comparisons

The reference edit

Ingredients, questions
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Connected source records selected through this article’s public topic index.

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Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Bakuchiol is a plant-derived antioxidant from the seeds of the Psoralea corylifolia plant. It has antimicrobial, emollient, skin conditioning, and antioxidant properties.
  4. 04You'll likely see it called a "retinol replacement" but the two are technically not related. This is because bakuchiol is able to flip many of the same switches in your skin cells to tell them to:
  5. 051) produce more collagen (type I, III, and IV) 2) activate the same genes retinoids do
  6. 06Unlike retinoids, this ingredient will not increase photosensitivity and is safe to use during pregnancy (but please still check in with your doctor!).
  7. 07The flagship clinical trial from Dhaliwal et al. 2019 found 0.5% bakuchiol (twice daily) and 0.5% retinol (once daily) reduced wrinkles and hyperpigmentation equally, but bakuchiol had significantly less irritation.
  8. 08Systematic reviews also back this up:
  9. 09Bakuchiol is comparable to retinol for photoaging but with better tolerability. It also has mild antibacterial properties against Cutibacterium acnes and antifungal activity in vitro against Candida and dermatophytes.
  10. 10The reason bakuchiol works well is due to its structure; it is a meroterpene phenol, or a hybrid molecule. The phenol half acts as an antioxidant while the terpene half is fat-loving. This helps the molecule slip through the skin barrier.
  11. 11This ingredient is usually used between 0.5-2%. Only one case of contact dermatitis has ever been reported for this ingredient.
  12. 12Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  13. 13Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  14. 14Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  15. 15Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
  16. 16The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure …
  17. 17Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
  18. 18Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
  19. 19It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
  20. 20On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Source · skinsort.com
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Product index

Related product references

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Comparison edit

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