Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Timeless Skin Care Matrixyl Synthe'6 Serum Versus The INKEY List Collagen Booster

Timeless Skin Care Matrixyl Synthe'6 Serum Versus The INKEY List Collagen Booster This anti-aging serum is formulated around Palmitoyl Tripeptide-38 and Hyaluronic Acid to soften the look of wrinkles and refine skin texture. This anti-aging serum is formulated

By Peptide Skincare & Beauty Editorial TeamPublished

Timeless Skin Care Matrixyl Synthe'6 Serum Versus The INKEY List Collagen Booster

This anti-aging serum is formulated around Palmitoyl Tripeptide-38 and Hyaluronic Acid to soften the look of wrinkles and refine skin texture.

This anti-aging serum is formulated around Palmitoyl Tetrapeptide-7 and Palmitoyl Tripeptide-1 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Hydroxypropyl Cyclodextrin

Palmitoyl Tripeptide-38

Aloe Barbadensis Leaf

Hyaluronic Acid

Benzyl Alcohol

Dehydroacetic Acid

Water, Glycerin, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38, Aloe Barbadensis Leaf, Hyaluronic Acid, Benzyl Alcohol, Dehydroacetic Acid

Butylene Glycol

Propanediol

Phenoxyethanol

Hydroxyethylcellulose

Disodium EDTA

Leuconostoc/Radish Root Ferment Filtrate

Carbomer

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine

Palmitoyl Dipeptide-5 Diaminohydroxybutyrate

Polysorbate 20

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Water, Glycerin, Butylene Glycol, Propanediol, Phenoxyethanol, Hydroxyethylcellulose, Disodium EDTA, Leuconostoc/Radish Root Ferment Filtrate, Carbomer, Hyaluronic Acid, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Polysorbate 20, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  4. 04Topically, glycerin does several things at once:
  5. 05Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  6. 06Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  7. 07This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  8. 08Just know very high concentrations (>40%) can feel tacky in low humidity.
  9. 09Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  10. 10This ingredient is used in skincare as a delivery system.
  11. 11It works by "encapsulating" active ingredients with its unique ring shape that is water-loving on the outside and oil-loving on the inside. This improves the stability and absorption of the product into the skin.
  12. 12According to a manufacturer, it also offer some moisturizing effects.
  13. 13This synthetic, signal peptide has unique skin conditioning properties in that is a matrikine-mimetic compound.
  14. 14First of all, Palmitoyl Tripeptide-38 is a signal peptide; signal peptides tell the body to create more collagen.
  15. 15What is a matrikine-mimetic compound?
  16. 16This peptide has the ability to mimic matrikines in skin. Our skin created matrikines by breaking down matrix proteins into peptides.
  17. 17Matrikines play a role in:
  18. 18Though further research is needed, this ingredient seems pretty promising. In one study, women over the age of 40 with visible photoaging used a vitamin C serum with this ingredient for 56 days (15% ascorbid acid, 5 ppm palmitoyl tripeptide‐38). The…
  19. 19This peptide is also part of the famous Matrixyl synthe’6, a blend of ingredients that also includes glycerin, water, and hydroxypropyl cyclodextrin.
  20. 20Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
Source · skinsort.com ⟶
02

Product index

Related product references

03

Comparison edit

Read side by side

Continue reading

Related articles