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Skin science article

Village 11 Factory Collagen Cream Versus Mizon Collagen Power Firming Eye Cream

Village 11 Factory Collagen Cream Versus Mizon Collagen Power Firming Eye Cream This anti-aging moisturizer is formulated around Adenosine and Copper Tripeptide-1 to soften the look of wrinkles and hydrate skin. This anti-aging eye moisturizer is formulated ar

Village 11 Factory Collagen Cream Versus Mizon Collagen Power Firming Eye Cream

This anti-aging moisturizer is formulated around Adenosine and Copper Tripeptide-1 to soften the look of wrinkles and hydrate skin.

This anti-aging eye moisturizer is formulated around Adenosine and Copper Tripeptide-1 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Hydrolyzed Collagen 71%

Glycerin

Dimethicone

Dipropylene Glycol

Water

2-Hexanol

Cyclopentasiloxane

Trehalose

Polysorbate 20

Cetearyl Dimethicone Crosspolymer

Cyclohexasiloxane

Carbomer

Tromethamine

Polyacrylate-13

Xanthan Gum

Fructooligosaccharides

Saccharide Hydrolysate

Pullulan

Adenosine

Butylene Glycol

Calcium Disodium EDTA

Centella Asiatica Extract

Houttuynia Cordata Extract

Salvia Hispanica Seed Extract

Sodium Hyaluronate

Coptis Chinensis Root Extract

Prunus Amygdalus Dulcis Seed Extract

Propolis Extract

Hydrolyzed Royal Jelly Extract

Beta-Glucan

Sambucus Nigra Flower Extract

Citrus Aurantium Flower Extract

Nelumbo Nucifera Flower Extract

Lilium Tigrinum Extract

Copper Tripeptide-1

Phenoxyethanol

Parfum

Hydrolyzed Collagen 71%, Glycerin, Dimethicone, Dipropylene Glycol, Water, 2-Hexanol, Cyclopentasiloxane, Trehalose, Polysorbate 20, Cetearyl Dimethicone Crosspolymer, Cyclohexasiloxane, Carbomer, Tromethamine, Polyacrylate-13, Xanthan Gum, Fructooligosaccharides, Saccharide Hydrolysate, Pullulan, Adenosine, Butylene Glycol, Calcium Disodium EDTA, Centella Asiatica Extract, Houttuynia Cordata Extract, Salvia Hispanica Seed Extract, Sodium Hyaluronate, Coptis Chinensis Root Extract, Prunus Amygdalus Dulcis Seed Extract, Propolis Extract, Hydrolyzed Royal Jelly Extract, Beta-Glucan, Sambucus Nigra Flower Extract, Citrus Aurantium Flower Extract, Nelumbo Nucifera Flower Extract, Lilium Tigrinum Extract, Copper Tripeptide-1, Phenoxyethanol, Parfum

Caprylyl Methicone

1,2-Hexanediol

Sodium Chloride

PEG-10 Dimethicone

C30-45 Alkyl Cetearyl Dimethicone Crosspolymer

Dimethicone/PEG-10/15 Crosspolymer

Sodium Citrate

PEG-9 Polydimethylsiloxyethyl Dimethicone

Hydrolyzed Collagen

Ethylhexylglycerin

Disodium EDTA

Limnanthes Alba Seed Oil

Olea Europaea Fruit Oil

Helianthus Annuus Seed Oil

Theobroma Cacao Seed Extract

Coptis Japonica Root Extract

Argania Spinosa Kernel Oil

Tocopherol

Mangifera Indica Seed Butter

Honey Extract

Fragaria Chiloensis Fruit Extract

Glycine

Caprylic/Capric Triglyceride

Serine

Glutamic Acid

Rubus Idaeus Fruit Extract

Aspartic Acid

Leucine

Hydrogenated Lecithin

Alanine

Lysine

Arginine

Tyrosine

Phenylalanine

Proline

Threonine

Valine

Isoleucine

Histidine

Cysteine

Methionine

Fragaria Vesca Fruit Extract

Phytosteryl/Octyldodecyl Lauroyl Glutamate

Ceramide NP

Water, Butylene Glycol, Glycerin, Cyclopentasiloxane, Cyclohexasiloxane, Dimethicone, Caprylyl Methicone, 1,2-Hexanediol, Sodium Chloride, PEG-10 Dimethicone, Cetearyl Dimethicone Crosspolymer, C30-45 Alkyl Cetearyl Dimethicone Crosspolymer, Dimethicone/PEG-10/15 Crosspolymer, Sodium Citrate, PEG-9 Polydimethylsiloxyethyl Dimethicone, Hydrolyzed Collagen, Ethylhexylglycerin, Adenosine, Disodium EDTA, Dipropylene Glycol, Limnanthes Alba Seed Oil, Olea Europaea Fruit Oil, Helianthus Annuus Seed Oil, Theobroma Cacao Seed Extract, Sodium Hyaluronate, Coptis Japonica Root Extract, Argania Spinosa Kernel Oil, Tocopherol, Mangifera Indica Seed Butter, Honey Extract, Beta-Glucan, Fragaria Chiloensis Fruit Extract, Glycine, Caprylic/Capric Triglyceride, Serine, Glutamic Acid, Rubus Idaeus Fruit Extract, Aspartic Acid, Leucine, Hydrogenated Lecithin, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Proline, Threonine, Valine, Isoleucine, Histidine, Cysteine, Methionine, Fragaria Vesca Fruit Extract, Phytosteryl/Octyldodecyl Lauroyl Glutamate, Copper Tripeptide-1, Ceramide NP

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Beta-Glucan is a soluble polysaccharide (a chain of glucose sugars) sourced from the cells walls of oats, baker's yeast, mushrooms, and seaweed.

It's a rare ingredient that pulls double-duty as a heavy-duty hydrator and skin-soothing repair agent.

On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin

The more interesting story is underneath:

Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair.

A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use.

It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive.

This ingredient gets along with pretty much everything and is typically used around 0.1-1%.

Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Cetearyl Dimethicone Crosspolymer is a type of silicone.

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Cyclohexasiloxane is a type of silicone more commonly known as D6. It is an emollient and solvent.

Cyclohexasiloxane is used to evenly distribute ingredients throughout the product. When applied to the skin, Cyclohexasiloxane evaporates and leaves behind a silky feel.

As an emollient, it can help the skin feel soft and hydrated. It is also used to reduce frizz in hair products.

Cyclopentasiloxane (D5) is a lightweight silicone that mostly acts as an emollient and solvent in cosmetics. Its the reason your products feel silky, fast-spreading, and non-greasy.

Since D5 is volatile, it does its thing and then evaporates off the skin quickly.

The safety profile of this ingredient is reassuring; the US CIR Expert Panel concluded D5 is safe as used in cosmetics and Health Canada concluded that D5 is not harmful to human health or the environment as currently used in cosmetics

There's a study that people mention about D5 in a rat study showing tumors. This study is related to long-term inhalation of high D5 levels.

Regulatory bodies have judged this study to be not applicable in topical skincare since skin absorption of D5 is very low and we're not really inhaling huge amounts of D5.

The only restriction for this ingredient is environmental. The European Chemicals Agency (ECHA) restricted D5 in wash-off cosmetics at or above 0.1% due to their persistence in water.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrolyzed Collagen is Collagen (usually sourced from fish, bovine, or porcine byproducts) that's been broken down into smaller peptides. This makes it water-soluble and easy to blend into formulations.

In a formula, it works mainly as a skin-conditioning and moisturizing agent.

The small peptides and amino acids (including Natural Moisturizing Factor components like Hydroxyproline, Serine, and Aspartic Acid) help the surface of the skin hold onto water, feel softer, and look temporarily plumper.

This ingredient also has mild film-forming and antioxidant properties with research showing the antioxidant effect is stronger the lower the molecular weight of the peptides.

It's worth being realistic here:

Topically applied Hydrolyzed Collagen conditions the upper layers of skin rather than rebuilding the structural collagen deep in your dermis (the wrinkle-and-firmness benefits people associate with Collagen mostly come from oral supplements in studies, not topicals).

However, recent lab and skin-model work on Hydrolyzed Fish Collagen has shown promising effects on cell viability and wound healing when used as an active.

Typical concentrations range from 0.2-2%, but the percentage can go much higher in rinse-off or hair products (sometimes even above 50%).

Clinical studies on this ingredient showed no irritation, sensitization, or phototoxicity.

If you are looking for vegan collagen, it usually goes by a different INCI name like hydrolyzed soy protein. Vegan collagen is derived from yeast, bacteria, or plant sources.

The results are varied.

A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70. Another study found increased skin thickness in participants between the ages of 45 to 59.

However, It is difficult to prove that oral collagen will end up working on your skin. Many of the studies using hydrolyzed collagen also add several vitamins and nutrients into the test mixture as well.

Further studies are needed at this time.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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