Skin science article
Wellage Real Hyaluronic Blue 100 Ampoule Versus JUMISO Waterfull Hyaluronic Acid Serum
Wellage Real Hyaluronic Blue 100 Ampoule Versus JUMISO Waterfull Hyaluronic Acid Serum This hydrating ampoule is formulated around Panthenol and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier. This hydrating serum is formulated around Sodiu
Wellage Real Hyaluronic Blue 100 Ampoule Versus JUMISO Waterfull Hyaluronic Acid Serum
This hydrating ampoule is formulated around Panthenol and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier.
This hydrating serum is formulated around Sodium Hyaluronate and Hydrolyzed Hyaluronic Acid to hydrate skin and strengthen the skin barrier.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Propanediol
Pentylene Glycol
Glycerin
1,2-Hexanediol
Panthenol
Methylpropanediol
Sodium Acrylic Acid/Ma Copolymer
Butylene Glycol
Dioscorea Japonica Root Extract
Xanthan Gum
Sodium Citrate
Ethylhexylglycerin
Sodium Hyaluronate
Glycosyl Trehalose
Hydrogenated Starch Hydrolysate
Citric Acid
Raffinose
Adenosine
Lecithin
Trisodium Ethylenediamine Disuccinate
Caprylyl Glycol
Saccharide Isomerate
Polyquaternium-51
Malachite Extract
Arginine
Sodium DNA
Alpinia Galanga Extract
Biosaccharide Gum-1
Cyanocobalamin
Tocopherol
Caprylic/Capric Triglyceride
Hydrogenated Lecithin
Hydrolyzed Hyaluronic Acid
Hydrolyzed Sodium Hyaluronate
Sucrose Laurate
Sodium Stearoyl Glutamate
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Glycine
Serine
Histidine
Glycine Soja Seed Extract
Lysolecithin
Phloretin
Tetrahydropiperine
Dimethyl Isosorbide
Sodium Hyaluronate Crosspolymer
Benzyl Glycol
Hydrolyzed Glycosaminoglycans
Oleyl Alcohol
Beta-Glucan
Hydroxypropyltrimonium Hyaluronate
Hyaluronic Acid
Sodium Acetylated Hyaluronate
Water, Propanediol, Pentylene Glycol, Glycerin, 1,2-Hexanediol, Panthenol, Methylpropanediol, Sodium Acrylic Acid/Ma Copolymer, Butylene Glycol, Dioscorea Japonica Root Extract, Xanthan Gum, Sodium Citrate, Ethylhexylglycerin, Sodium Hyaluronate, Glycosyl Trehalose, Hydrogenated Starch Hydrolysate, Citric Acid, Raffinose, Adenosine, Lecithin, Trisodium Ethylenediamine Disuccinate, Caprylyl Glycol, Saccharide Isomerate, Polyquaternium-51, Malachite Extract, Arginine, Sodium DNA, Alpinia Galanga Extract, Biosaccharide Gum-1, Cyanocobalamin, Tocopherol, Caprylic/Capric Triglyceride, Hydrogenated Lecithin, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Sucrose Laurate, Sodium Stearoyl Glutamate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Glycine, Serine, Histidine, Glycine Soja Seed Extract, Lysolecithin, Phloretin, Tetrahydropiperine, Dimethyl Isosorbide, Sodium Hyaluronate Crosspolymer, Benzyl Glycol, Hydrolyzed Glycosaminoglycans, Oleyl Alcohol, Beta-Glucan, Hydroxypropyltrimonium Hyaluronate, Hyaluronic Acid, Sodium Acetylated Hyaluronate
Dipropylene Glycol
Chlorella Vulgaris Extract
Betaine
Trehalose
Polyglyceryl-10 Laurate
Glucose
Fructooligosaccharides
Fructose
Tromethamine
Glyceryl Acrylate/Acrylic Acid Copolymer
Allantoin
Choleth-24
Ceramide NP
Carbomer
Water, Butylene Glycol, Glycerin, Dipropylene Glycol, 1,2-Hexanediol, Pentylene Glycol, Sodium Hyaluronate, Chlorella Vulgaris Extract, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Betaine, Panthenol, Trehalose, Polyglyceryl-10 Laurate, Glucose, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Fructooligosaccharides, Fructose, Tromethamine, Ethylhexylglycerin, Glyceryl Acrylate/Acrylic Acid Copolymer, Allantoin, Choleth-24, Hydrogenated Lecithin, Tocopherol, Ceramide NP, Carbomer, Xanthan Gum
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Ammonium Acryloyldimethyltaurate/Vp Copolymer is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.
Think of it as a supportive ingredient that helps your gel-creams feel silky, "cloud cream-like", and spread evenly without being greasy.
The Cosmetic Ingredient Review (CIR) Expert Panel evaluated it (along with 22 other acryloyldimethyltaurate polymers) and concluded it's:
Due to its large molecular size, it sits on the surface of skin rather than penetrating it.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.
Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.
The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
This is why the best HA serums blend the two sizes together so you get the best of both worlds.
The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.
A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.
These are some other common types of Hyaluronic Acid:
Hydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.
It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.
Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.
Most formulations will combine all sizes to get the best of both worlds.
Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.